ANZCTR search results

The study aims to determine whether vitamin D deficiency is associated with increased cardiovascular risk and whether that risk is reversed by vitamin D replacement.

Pain treatment is vital part of postoperative care as a delayed or insufficient treatment of pain can significantly impair a patients outcome. Prerequisite of successfull treatment is the assessment of pain. This can be difficult in younger children who lack the ability to communicate their pain. Aim of this observational trial is to define the relationship between physiological parameters such as blood pressure, heart rate, skin conductance parameters and heart rate variability and acute postoperative pain. At the same time, we aim to prospectively test cut-off values for the skin conductance parameter "number of skin conductance fluctuations per second" (NFSC) obtained in an earlier study to distinguish between no/mild and moderate/severe pain. 150 peadiatric patients aged 1-16 after elective surgery will be included and the relationship between above mentioned parameters and acute postoperative pain (measured on standard pain scales during the patients stay in the recovery room) will be examined.

The purpose of this study is to investigate the difference in torsion in primary position (head straight, looking straight ahead) and compare it to measurements in 15 and 30 degrees in downgaze (head straight, eyes looking downwards). It is hypothesised that torsion will increase in downgaze, especially in cases of bilateral superior oblique palsy. Therefore, we hope to establish an amount of torsion that differentiates bilateral and unilateral superior oblique palsy. This will help clinicians plan treatment and hopes to avoid cases of "masked" superior oblique palsy (where after surgery for a unilateral superior oblique palsy, a superior oblique palsy is uncovered in the other eye).

Cannabis is often a difficult drug to stop, and its regular use often causes dependence and withdrawal symptoms when attempting to stop. In Australia, the major treatment available for cannabis dependence is counselling, but many individuals find that counselling for cannabis use is not effective, particularly because of the withdrawal symptoms that occur. This project will assess a new treatment for cannabis dependence in patients who are seeking treatment to stop their cannabis use, and uses a combination of medications that aim to block the effects of cannabis withdrawal in the brain, and so reduce the severity of cannabis withdrawal symptoms. The three medications used in combination are tiagabine, acamprosate and mirtazapine. Participants will be allocated to one of two treatment groups. One treatment group will receive a combination of the three active medications, tiagabine, acamprosate and mirtazapine for a period of 12 weeks. The second treatment group will receive placebo (dummy) medications for 12 weeks. Allocation to either group will be by a randomisation process – like flipping a coin. All patients in the trial will also receive a program of weekly counselling and support. Patients will participate in the trial for a period of six months.

A new simple method of looking at the upper digestive tract has been developed. This is a capsule that has a camera inside it called PillCam ESO. The aim of this study is to compare the diagnostic effectiveness of PillCam ESO endoscopy with standard endsocopy in people with gastrointestinal bleeding.

The aim of this project is to determine the best way to harvest an artery that is commonly used in cardiac surgery from behind the chest bone to allow best possible result.

This study will compare the safety and efficacy of the mixture formulation consisting of liposomal and free ciprofloxacin for inhalation to placebo for inhalation in patients who have a confirmed diagnosis of non-CF bronchiectasis with a history of chronic Pseudomonas Aeruginosa infections.

This is a phase I trial to assess the safety and tolerability of a new anti-anxiety drug over a wide range of doses. This will enable doses, that are safe and produce good levels of drug in the body, to be selected for further studies in which measurement of anti-anxiety activity may be done.

Randomised double-blind placebo controlled study to measure the effect of antiretroviral therapy (ART) intensification with raltegravir and/or hyper-immune bovine colostrum on CD4+ T cell count in ART treated, HIV-1 infected individuals who have failed to achieve a CD4+ T cell count greater than 350 cells/µL despite persistent HIV plasma viraemia below 50 copies/mL on cART.

This study aims to identify whether the use of chlorpromazine is more effective than standard therapy at treating vomiting associated with Cannabis Hyperemesis Syndrome. The cause of this condition is unknown but similar syndromes of Adult Cylclical vomiting are thought to be related to migraines. Chlorpromazine has been chosen because it is both an antiemetic and anti-migraine therapy.