ANZCTR search results

A prospective randomized trial of the method of follow-up: cases registered in a national registry who were 3-months post-stroke receive the survey by mail or telephone. Data included collection of stroke and re-hospitalisation rates, and health-related quality of life. Response rates, time to response, and completeness of data were compared. Factors potentially associated with the outcome were explored.

An experimental study to compare the brain effects of needle versus laser acupuncture on one acupoint (LR8) in healthy subjects using functional MRI.

The study investigated the pharmacokinetics of phenoxodiol given as an intravenous bolus and a continuous intravenous infusion in a first-in-human study, to patients with advanced cancer.

The study compares the feasibility of two different consent mechanisms for parental participation in data linkage of their infants’ vaccination and health records to evaluate vaccine safety. When their infant is 6 weeks of age (prior to their 2 month vaccinations) parents will be sent an information sheet about the study. In the opt-in arm, parents will be asked to signal willingness to participate in data linkage by returning a signed reply form (or can phone or email). In the opt-out arm, all parents will be included unless they indicate an unwillingness to participate by returning a signed reply form (or can phone or email). When their infant is 10 weeks of age (after their 2 month vaccinations), every household will be called and a parent will be asked to participate in a 20 minute telephone interview, in order to elicit attitudes, and knowledge about, data linkage, consent preferences, and their baby’s vaccination status. This study will examine the following null hypotheses: Primary hypothesis That an opt-in or opt-out method of consent will result in an equal proportion of parents consenting to participate in a study of vaccine safety data linkage. Secondary hypotheses Neither consent option will result in parental participation >90%. That there are no differences in parental demographics between those who choose to participate in data linkage and those who do not.

Overweight and obesity are the most common clinical risk factors affecting over 30% of the pregnancy population. Furthermore, excessive weight gain while pregnant also leads to increased morbidity and mortality for the woman and the fetus/neonate. The morbidity includes, for the fetus/neonate: macrosomia, shoulder dystocia, hypoglycemia and admission to the nursery and for the mother: high blood pressure, gestational diabetes, increased caesarean section rates and increased rates of overweight and obesity post pregnancy. A number of studies have targeted diet and exercise with varied effect. No study has focused on routinely weighing patients in clinic to provide regular feedback that may act as a positive behavioural component to limit weight gain. This study will investigate the effect of weighing pregnant patients at each antenatal clinic visit compared with routine care (weight recorded at the booking visit). All patients attending the Royal Women’s Hospital for their booking visit (<20weeks gestation) will be approached by a midwife or doctor. Only women planning to have all their antenatal care at the Royal Women's Hospital, and with no obvious medical problems, will be included. Once consented, patients will then be randomised into either the control or the intervention groups. Patients in the intervention group will be weighed at every antenatal visit until 36-38 weeks gestation, while the control group will receive routine care with a booking weight plus a weight at 36-38 weeks gestation. Information will be obtained about their demographics, previous pregnancies, medical problems and delivery. Participants will complete a questionnaire at the end of the study regarding their perception of being weighed. We will then analyse the mean pregnancy weight gain of the intervention group compared to the control group. We will also analyse the data according to the Body Mass Index (BMI) at entry to determine if particular subgroups of women (ie underweight, normal weight, overweight and obese) appear to have a different response to being weighed. We will also compare the neonatal outcomes to ensure there is no obvious harm in the process of regular weighing. This study will allow us to determine if weighing patients regularly does provide a positive behavioural component resulting in appropriate weight gain in pregnancy.

The aim of this study is to evaluate the effects of a physical activity and nutrition program for low-active adolescent girls from economically disadvantaged secondary schools. The study will assess changes in body composition, physical activity, dietary behaviours, and hypothesized mediators of behaviour change over a 24 month period.

The primary purpose of the study is to test whether intra-oral manual therapy for chronic myogenous temporomandibular disorder coupled with self care exercises and education is more effective than either manual therapy alone or no treatment (control).

The clinical trial is to assess the safety and tolerability and to explore the efficacy of orally inhaled heparin in patients with cystic fibrosis (CF). Heparin is expected to provide advantages over currently available treatments for CF in a convenient delivery system.

In a previous study on bronchiolitis in Aboriginal children we found that 67% were from remote communties and required retrievals. A recent study has also shown that almost 2.5% of Aboriginal children in Australia's Northern Territory will be hospitalised for bronchiolitis more than once before reaching the age of 18 months. Multiple hospitalised respiratory infections and the severity of these infections are risk factors for developing chronic lung diseases including bronchiectisis and asthma. It is planned that this study will provide an estimation of the effect of azithromycin on the severity of bronchiolitis in Aboriginal and non Aboriginal infants. Assessing redmission for respiratory illness within 6 months may provide some indication of the medium term benefit of three doses of azithromycin, given to infants in the acute phase of viral bronchiolitis, in reducing the risk of further respiratory illness requiring hospitalisation.

In this study we will continue to follow participants recruited to " A longitudinal study of caries prevention in children aged two to four years" HREC/09/QPAH/158, ACTRN12609000330246 who have undergone preventative methods of education, home visits and toothbrushing with fluoride toothpaste, 0.12% chlorhexideine gel and CPP-ACP Tooth Mousse. The effectiveness of these strategies will be assessed through -microbial analysis for the presence of decay causing bacteria - clinical dental examination data - statistical analysis of data for case and control groups