ANZCTR search results

This study is designed to compare the safety and efficacy of the investigational drug MT10109, a new formulation of Clostridium Botulinum Toxin Type A compared to Botox (Registered trademark). Subjects will have a single injection of MT10109 injected into the Extensor Digitorum Brevis (EDB) muscle of one foot and an equivalent dosage of Botox injected into the other foot.

This study aims to improve GPs' management of atrial fibrillation to prevent stroke.

The prevalence of Gestational Diabetes (GDM) in Australia is approximately 5%-8%, with up to one third of all parous women who develop type 2 diabetes having a previous history of GDM . Research to determine strategies to delay or prevent the development of or progression to diabetes is vital, particularly in population groups that are at higher risk, such as GDM, and obese women (BMI.>25). A pilot randomised controlled trial (RCT) conducted at Mater Mothers Hospital suggested that a post partum intervention designed to increase physical activity in women with previous GDM may be feasible. A recent study in the United States recruited women with recent GDM into an RCT where the control group received usual care and the intervention group received a web based pedometer program. Dietary intervention has been proven to increase probability of weight loss, so a strategy of combining both a pedometer and nutrition based program may prove to be more successful in long term improvement in a healthy lifestyle to prevent type 2 diabetes. The aim of this study is to develop long term statergies for women who develop GDM during their pregnancy and are overweight (BMI > 25) to improve their lifestyle to possibly prevent Type 2 diabetes. This randomised controlled trial is a pedometer - based inervention to encourage physical activity , combined with nutrition coaching, and will possibly result in an increased weight loss, improved insulin sensitivity and increased physical activity when compared with standard care. This project aims to take another step towards the larger scale issue of providing adequate, evidence based follow up care for women who develop GDM in their pregnancies.

The aim of this study is to conduct a randomised controlled trial to compare two forms of manual therapy against each other and to a placebo in reducing symptoms of cervicogenic dizziness (imbalance and neck pain) in the longer term. Although these are standard treatments in physiotherapy practice they have not been fully evaluated. Outcome measures will be five self-report questionnaires, keeping a diary and measurements of neck range-of-motion, head repositioning and balance.

The hypothesis is that a woman can be guided by an interactive computer application to adequately recognise and record her natural fertility symptoms and that the application can use this knowledge to inform her about fertility awareness according to the Billings Method of natural family planning. Method: Women in the age bracket 18-38 will be recruited by advertising. Participants will download the application software to their PC and follow the guidance system to make thier fertility observations and receive feedback for the next 100 days. At the end of the 100 day period participants will submit their fertility data for analysis and subsequent interview. A pilot study involving about 30 participants will be initially undertaken.

The study aims to establish whether taurocholic acid, administered as an enema, can stimulate secretion of the gut peptides GLP-1, PYY, and oxyntomodulin, and suppress subsequent appetite and food intake. This information could be useful in designing treatments for type 2 diabetes and obesity.

We plan to test the hypothesis that, in children with central lines admitted to intensive care, intravenous (through a drip) heparin at a low dose prevents clots developing around the central line, compared to saline, an inactive placebo. Clots will be sought using ultrasound.

Cystic Fibrosis (CF) is the most common life-threatening genetic condition affecting Australian children. As well as repeated lung infections, children with CF develop insulin deficiency and eventually diabetes. The CF-IDEA trial (Cystic Fibrosis – Insulin Deficiency, Early Action) will determine whether starting insulin treatment before the onset of diabetes (earlier than current practice) will improve the health of children with CF by improving body weight and lung function.

Participants come for one practice visit where they go through the screening questions and provide informed consent. They also practice on all cognitive and mood tasks they will be doing on their subsequent testing sessions. Participants come for 3 testing sessions at least 1 week apart. At each testing session, they first complete baseline 'mood, cognitive, mood' assessments and doppler ultrasound followed by treatment administration. They complete 'mood, cognitive mood' assessment at 40mins and 120mins post dose and doppler at 90mins post dose

This study looks at the effect of a progressive exercise program on shoulder pain and function following nerve injury after neck dissection surgery for cancer. Who is it for? You can join this study if you have undergone neck dissection surgery for head and neck cancer within eight weeks and you have clinical signs of injury to the accessory nerve which includes weakness of shoulder movements. Trial details Participants will be randomly divided into two groups. One group (control) will receive standard care (physiotherapy or a handout of generalised exercises and advice about scar care). The other group will attend the physiotherapy department for a supervised exercise program. This involves progressive strengthening exercises for half an hour, once a week for 12 weeks, with the same exercises performed at home twice a week. Assessments will be carried out at the start of the study and at 3, 6 and 12 months. The study aims to compare levels of pain, disability and shoulder movement in the different groups.