ANZCTR search results

2 randomised controlled trials have demonstrated the safety and efficacy of cabergoline to limit the development of ovarian hyperstimulation syndrome (OHSS) in women at risk of this condition undergoing IVF treatment. This prospective observational study aims to look at the incidence of the development of the condition and any side-effects caused by the administration of cabergoline by women at risk of OHSS.

Non Alcoholic Fatty Liver Disease (NAFLD) is a well described complication of type 2 diabetes. It is a disease with a broad spectrum of severity with the most aggressive form of it Non Alcoholic Steato-Hepatitis (NASH) often progressing to liver cirrhosis. Up until now the liver biopsy had been the gold standard in determining the stage of liver disease (or fibrosis) in such patients however a liver biopsy is costly, invasive and associated with complications including death. In recent years a new technique called fibroscan (Transient Elastography) has been validated as a non-invasive method of measuring liver fibrosis .Fibroscan(Transient Elastography) works by transmitting a vibration through the liver with the aid of ultrasound , this gives an impression of how stiff the liver is and liver stiffness can be directly equated to liver fibrosis. New blood markers are also now available which can accurately estimate degrees of liver fibrosis and add to traditional methods of assessing for liver disease. No studies as of yet have been done in assessing the utility of the fibroscan(Transient Elastography) and serum fibrosis markers in a type 2 diabetic population.

Current practice is that once patients are discharged from hospital after surgery they do not have dietetic follow up. The aim of this study is to investigate whether individualised nutrition counselling improves nutritional status and quality of life in the 6 months post-discharge.

Demographic variables such as age, sex, race and body weight as well as genetic, environmental and cultural factors (eg, diet) may influence the safety & therapeutic response to drugs. Therefore, this study aims to investigate these differences in Japanese, Chinese and Caucasian subjects.

This research project aims to evaluate prospectively the effectiveness of an 8-week Mindfulness-Based Cognitive Therapy (MBCT) group program implemented for individuals with a Spinal Cord Injury. The study hypothesis is that the implementation of an 8-week MBCT group program for Spinal Cord Injured individuals will facilitate improvements in psychosocial and behavioural functional outcomes post group program and these improvements in therapeutic outcomes will be maintained up to 3 months after completion of the MBCT group program.

This research project aims to evaluate prospectively the effectiveness of an 8-week Mindfulness-Based Cognitive Therapy (MBCT) group program implemented for Stroke survivors. The study hypothesis is that the implementation of an 8-week MBCT group program for Stroke survivors will facilitate improvements in psychosocial and behavioural functional outcomes post group program and these improvements in therapeutic outcomes will be maintained up to 3 months after completion of the MBCT group program.

Manual therapy techniques are commonly used by physiotherapists to improve pain and function in patients affected by osteoarthritis. The aim of this study is to determine if a specific manual therapy technique immediately decreases pain and improves function in people with knee osteoarthritis. It is hypothesised that the manual therapy technique will reduce pain and increase knee range of movement significantly more than either a placebo technique or control(no treatment).

This aim of this study is to assess the safety of different doses of anovel orally-administered iron chelator in patients with iron-overload.

The efficacy of treatment for social phobia at the Anxiety Disorders Clinic is proven with benefits in the short and long term exceeding 1 standard deviation (SD) (McEvoy, 2007). Therapy over the internet has also been shown to be efficacious, again with benefits in the short and long term exceeding 1 SD (Titov et al, 2009). Whilst on this basis the two modes of therapy appear comparable in efficacy we cannot know whether people applying for internet therapy are particularly suited to that mode of treatment and whether people applying for face to face therapy are suited to that mode of therapy. Internet therapy has service delivery advantages in terms of substantial reductions in therapist time and reductions in patient costs in terms of transport to the clinic which averages $30 per visit, and in terms of loss of wages or cost of carers while away from home.

This research project aims to evaluate prospectively the effectiveness of an 8-week Mindfulness-Based Cognitive Therapy (MBCT) group program implemented for adults who stutter. The study hypothesis is that the implementation of an 8-week MBCT group program for adults who stutter will facilitate improvements in psychosocial and behavioural functional outcomes post group program and these improvements in therapeutic outcomes will be maintained up to 3 months after completion of the MBCT group program.