ANZCTR search results

This trial will assess the effects of a 'healthy brain ageing program' for older adults at risk of cognitive decline and/or dementia. It incorporates both cognitive training as well as information that will equip participants with knowledge regarding preventative risks for depression and cognitive decline. It is expected that those who participate in the treatment will improve in terms of memory functioning.

Purpose of trial is to compare Continuous positive airway pressure (CPAP) versus conventional therapy of inspired postive pressure ventilation with bag valve mask.

Epidural anaesthesia has a mitigating influence on adverse metabolic effects that may influence the outcome from surgery. This trial was designed to investigate whether extending epidural analgesia into the postoperative period improves outcome from high risk vascular bypass surgery

This study looks how accurately some monitoring systems perform during major surgery. One device looks at flow in a major artery and uses a probe inserted into the gullet under general anaesthesia. The other device/s reads a signal from a standard line inserted into a small blood vessel in your arm to record the blood pressure. The aim is to see whether these devices measure changes in blood flow accurately during surgery. As these devices are relatively new, it is important to identify wihch monitor is most accurate in helping the anaesthetic doctor to make potentially important decisions. It is an observational study and does not change your anaesthetic in a significant way.

The purpose of the study is to determine which surgical technique provides the best alignment for total knee replacements The null hypothesis is that all techniques are equally good.

A six-month study exploring the effectiveness of a a liver failure program for patients who have cirrhosis of the liver and are admitted to hospital with a liver-related issue.

Prospective study to be conducted at Monash Medical Centre Moorabbin Melbourne Victoria. The aim is to determine whether Positron Emission Tomography combined with computed tomography (PET/CT) is able to predict the stage and spread of uterine (Endometrial) Cancer when performed preoperatively. A further aim is to determine whether its use is beneficial in guiding further treatment of the patient, With our hypothesis being that PET/CT is useful in ensuring appropriate management of the woman with uterine cancer

Barrett’s oesophagus (BE) involves changes in the lining of the oesophagus and is a precursor for a type of oesophageal cancer. Obesity is a cause of BE and research suggests that certain hormones produced by fat tissue may be the mechanism through which obesity leads to cancer of the oesophagus. Exercise training may be an effective intervention in reducing oesophageal cancer risk given the strong links between BE, obesity and metabolic disturbances. There is some trial evidence that moderate-intensity exercise can improve obesity related hormone levels in overweight people without BE, but to date, no such evidence exists for patients with BE. By randomising patients with BE to either an exercise regimen or a stretching regimen, we aim to determine whether 24 weeks of moderate-intensity exercise will lead to changes in levels of certain hormones associated with oesophageal cancer development.

Trial has been completed with all data collected and analysed The main aim of the study was to demonstrate the effectiveness of multimodal manipulative therapy for shoulder pain, and to demonstrate the utility of care offered by this therapeutic procedure. To demonstrate the effectiveness of multimodal manipulative therapy for chronic shoulder pain sufferers. To demonstrate that multimodal manipulative therapy is an effective therapeutic option offering short term symptomatic improvement which is maintained over a medium period of time (>than 4 months).

Study rationale: Bone marrow oedema has recently been recognized to be a key correlate of knee pain. There is no known treatment for this problem but it is very common in those over 50 (30% of a random sample of 50-80 year olds in Hobart) (Zhai, 2006). There are no randomized trials but there is some observational evidence suggesting bisphosphonates modify this process. Firstly, they are much less common in population samples using bisphosphonates (OR 0.1) (Carbone 2004) and an open label study with IV ibandronate led to rapid resolution of hip bone marrow oedema (Ringe 2004) when natural history studies in the knee do not suggest resolution. Zoledronic acid is an attractive candidate for the treatment of this condition dues to its one off administration and potential for long term efficacy