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Informed consent obtained to take blood tests for AMH level estimation before surgery andat 2 time points afterwards

The aim of this project is to investigate if the currently run circuit class at the brain injury rehabilitation unit at Liverpool Hospital currently fulfills one of its aims, that is, to provide a fitness effect. For patients who are currently not working at a sufficient heart rate intensity for a fitness effect, we are investigating if the use of heart rate monitors increases the intensity that patients are able to work at.

Phase 1 This is trial of the drug BNC105P for treating people with advanced solid tumours. Who is it for? Participation in this study is open to patients who have advanced solid cancers of any type (excluding brain tumours), are 18 years and over and meet the study inclusion and exclusion criteria. Trial details Participants will receive BNC105P intravenously on days 1 and 8 of a 21 day cycle, for a minimum of 2 cycles. Blood tests and imaging will be carried out throughout the treatment cycles to monitor safety, tumour response and suppression of cancer growth. The trial aims to test the safety and determine the maximum tolerated dose of BNC105P. This is an experimental anti-cancer drug which disrupts the blood supply within tumours and is cytotoxic to cancer cells.

The objective of the study is to assess the effectiveness of a community-based exercise program for people with dementia in reducing functional decline in the areas of cognitive, physical and behavioural functioning.

Cardiology patients who receive an implanted device (pacemaker, implantable cardioverter defibrillator or cardiac resynchronisation therapy device) return to their doctor on a regular basis to have their device interrogated and followed-up. There is a new method of following-up these devices from the patient’s home called the Medtronic CareLink Network. Patients use a Monitor to interrogate their implanted device (that is, to collect information from the device using the antenna attached to the Monitor). The monitor then uses an analogue “landline” to send the encrypted data to the central database. Clinicians can access the information from the patient’s implanted devices by logging into the secure, password-protected Website. The goal of the ACQUIRE Study is to assess the impact of remote device monitoring on time and financial burden for patients, clinicians and clinics themselves. Furthermore, the acceptance, ease of use, satisfaction and impact of the system will be assessed for both patients and clinicians, respectively. The time and financial impact will be investigated in order to better understand the potential value to economic stakeholders. The economic stakeholders include patients, caregivers, clinicians, and health care systems.

Children with chronic illness sometimes feel disconnected and lonely. In this study we will evaluate the use of a psycho-social intervention program for 'at-risk' children (ie. child with chronic illness, low socio-economic groups) to improve their sense of well-being, adherence to therapies and health outcomes.

The purpose of this project is to determine what is the most appropriate method of investigation of lung masses, or suspected lung cancer. Currently there is no guidance for clinicians as to which of the two commonest methods (bronchoscopy or CT-guided lung biopsy) is optimal. Our study hopes to determine if one of these two diagnostic procedures is more appropriate than the other in investigating patients with lung masses or suspected lung cancer. While either may be performed at present, there is no information to guide clinicians as to particular clinical features that may make one procedure more beneficial than the other, both in terms of maximizing the rate of achieving a diagnosis and also in minimizing the rate of complications.

Aim: This project will assess the safety, effectiveness and patient acceptability of administering the medication, flumazenil, to treat benzodiazepine dependence by means of subcutaneous (under the skin) infusion rather than by intravenous infusion. Background: Benzodiazepines are a group of sedative drugs which are commonly prescribed for anxiety and insomnia. Examples include “valium”, “serepax”, and “mogadon”. Dependence on this group of drugs can occur rapidly with regular use, and successful withdrawal and treatment is very difficult. Long-term dependence on benzodiazepines, either prescribed or obtained illicitly through diversion, is therefore recognized as a major public health issue. Current treatment for benzodiazepine dependence usually involves a slow reduction in the benzodiazepine dose over weeks, but is frequently unsuccessful because of the withdrawal symptoms of anxiety and agitation that occur, and so patients remain on benzodiazepines long-term. Flumazenil is a medication that has recently been successfully used to treat benzodiazepine dependence by giving it as an intravenous infusion over several days. Unfortunately, using this method of intravenous infusion is complex and resource intensive, and this limits the availability of this form of treatment for many patients. This project is a pilot study to determine whether giving flumazenil by the simpler subcutaneous route would be an effective alternative that could make treatment available to many more patients.

People with brain metastases from melanoma are offered different treatment options after local treatment of their brain metastases via surgery or stereotactic irradiation. Depending on the treating institution and the clinician involved a patient may or may not be offered whole brain radiotherapy (WBRT) after their brain metastases are excised or treated with stereotactic irradiation. This trial seeks to determine if WBRT reduces the spread of brain metastases and lengthens the time to recurrence. The trial also examines the effect of WBRT on quality of life and brain functions such as memory, speech and concentration. Participants will be randomised after local treatment of their brain metastases to either WBRT or observation. 200 people will be recruited from sites in Australia, Norway, the UK, the US and other international sites.

Exercise is used to make a diagnosis of exercise induced bronchoconstriction (narrowing of the airways) in children and adults with a history of breathlessness during or after exertion. We are aiming to find out how much change in exhaled nitric oxide occurs after exercise and whether the amount of exhaled nitric oxide is related to exercise induced cough.