ANZCTR search results

Collaborative Assessment and Management of Suicide (CAMS) is a psychological therapy that outperforms other active interventions in reducing suicidal ideation, improving distress and hopelessness, reducing treatment disengagement and higher consumer satisfaction. Only two trials have investigated CAMS delivered within inpatient settings and neither have been conducted in Australia. Within this context, the aim of this study is to investigate whether it is feasible to deliver CAMS in the Australian inpatient setting, whether the treatment is acceptable to consumers and clinicians and ensure outcomes are in line with what would be expected. CAMS may be a good fit for Australian psychiatric inpatient settings, but the relevance and feasibility of this approach is yet to be established here.

This multi-method evaluation will assess the feasibility, acceptability, and effectiveness of a caregiver wellbeing program delivered by CaFHS in South Australia. The caregiver wellbeing program will deliver evidence-informed caregiver wellbeing psychoeducation into these routine services. Our evaluation aims to determine whether the caregiver wellbeing program is feasible and acceptable to deliver within these routine services and whether it is effective in improving the wellbeing of caregivers. To achieve our aims, we will conduct pre- and post- program surveys and post-program focus groups with caregivers who participated in the program, and staff who were involved in implementing or delivering the program. To support and evaluate a future statewide roll out, this study will also evaluate the feasibility of conducting a definitive trial.

This study aims to determined if a 3 week treatment using the Niagara® Cycloid® massage pad has an impact on chronic unilateral chronic oedema/lymphoedema of the legs arising because of treatment for cancer. Who is it for? You may be eligible for this study if you a patient clinically diagnosed with chronic oedema/lymphoedema (arising from treatment for cancer) of one leg, more than 1.5 years duration but less than 10 years, either Overweight or moderately obese. Study details Participants who meet the eligibility criteria in this study will be randomly selected to be part of one of two treatment groups: Group 1: participants will continue with their usual treatment for their oedema/lymphoedema, or Group 2: participants will use the massage pad for 3 weeks at home. Participants will then be followed up at 7 timepoints via ultrasound, questionnaire and other assessments for up to 1 month after completion of the 3 week intervention period. It is hoped that this treatment will primarily help reduce fluids in the affected leg, resulting in reduced pain and tension and heaviness as well as making the limb smaller.

The research project will involve a randomised controlled trial of Daily Growth, a smartphone parenting app for parents and carers of children aged 2-5 years. The trial aims to: 1. Evaluate the real-world effectiveness of a 6-week, in-the-moment, tailored Daily Growth app for parents of children 2-5 years. 2. Compare the effectiveness of parents receiving multiple types of a parenting program to parents receiving no parenting program or just one type of parenting program. The research team hypothesises that participants receiving the randomised version of the Daily Growth app will be more acceptable to parents and more beneficial in improving parent and child emotion regulation and mental health compared to (a) no support, or (b) parenting support from a single program.

Healthy eating is important for fertility and overall health. This study aims to compare the effects of two different healthy diets (a Mediterranean diet and the Australian Dietary Guidelines) given to couples undergoing in vitro fertilisation (IVF). Specifically, we want to understand how these two different diets affect outcomes of IVF. We also want to understand how couples undergoing IVF feel about following these diets (e.g. whether they enjoy following it, and any challenges they faced while following the diet). Currently, the Australian Dietary Guidelines are recommended for all healthy Australians as well as those with different health conditions, including pregnancy. In this study, we are comparing the effects of the Mediterranean diet, which may also help with fertility, to the Australian Dietary Guidelines. We hypothesise that a Mediterranean diet will result in a higher number of embryos produced from IVF treatment.

This study is investigating a new agent to be used in PET imaging for prostate cancer, called 68Ga-NTA-476. It aims to find out where 68Ga-NTA-476 goes in the body once it is injected into a person and whether there are any side effects or issues with tolerating the compound. This will be compared to an existing imaging compound which is currently used in Australia called 18F-DCFPyl. 68Ga-NTA-476 has been developed and tested in the laboratory; however, this is the first time that it will be tested in humans. It is hoped that this compound will provide more accurate PET imaging with less non-specific activity to enhance diagnostic and therapeutic outcomes. Who is it for? You may be eligible for this study if you are an adult older than 18 years of age, you have been diagnosed with prostate cancer and do not have any significant other health issues. Study details All participants who choose to participate will complete a Screening Visit to make sure that they meet the eligibility requirements for the study. Procedures completed during this visit will include demographic details, medical history, physical examination, vital signs, ECG, blood samples to check overall health status and a 18F-DCFPyl PET scan. Following confirmation of eligibility, participants will complete an Imaging Day Visit. During this visit, single dose of 68Ga-NTA-476 will be injected via a vein into the body. Following this, PET scans will be completed at about 0-30 minutes, 1 hour, and 4-6 hours. Participants will be observed in the clinical for a total of 6 hours to check vital signs and record any side effects. Between 7-9 days after this, a final study visit will be completed. Blood samples will be collected to check overall health status and the research team will check to see if any side effects were experienced. A total of 10 participants will be enrolled in this study at Melbourne Theranostic Innovation Centre in Australia

The internet and social media have been powerful tools to educate the public about social issues. However, some information is incorrect, and it can be difficult to know which information to trust. Online education offers an effective and efficient way of learning about important social issues like climate change and vaccines. This research project’s goal was to test the effectiveness of an online tool that educates people about important social issues. We tested whether one online tool was more effective than another at educating people about important social issues.

The purpose of the study is to determine the feasibility of pre-operative educational videos on bowel cancer related functional recovery. Who is it for? You may be eligible for this study if you are an adult who has had pre-operative clinical staging confirming stage I-III or limited stage IV colorectal cancer. In addition, you should have elective surgery for cancer resection +/- temporary stoma scheduled >7 days after the time of referral to the study. Study details At least 5 days before your scheduled surgical procedure, participants will be asked to view a series of 4 videos with estimated duration 6-10 minutes each, covering the topics of bowel and general health, bowel, bladder and sexual function, and pelvic floor muscle exercise. Following this, participants will be asked to complete satisfaction and knowledge measures. It is hoped that findings from this study will help investigators develop tools to aid patient understanding of bowel issues associated with surgery and provide coping strategies for the potential side effects from surgery and treatment.

Infants born to mothers with gestational diabetes have abnormal gut bacteria, which may predispose them to adverse health outcomes such as inflammatory disorders, allergies, diabetes, obesity, neuro-developmental and neuro-behavioural impairment, cardiovascular and immune-mediated diseases. We aim to supplement these infants with probiotics to alter the bad bacteria with the hope to improve their health outcomes. Currently there are no trials in this area.

In critically ill patients, especially those requiring mechanical ventilation, enteral nutrition is a fundamental aspect of metabolic support. When oral feeding is insufficient to meet nutritional needs, enteral feeding becomes the preferred method of nutritional support. However, more than 50% of ICU patients experience gastric dysmotility, which leads to reduced rates of gastric emptying. This can result in several complications, such as regurgitation and aspiration, increasing the risk of developing pneumonia. Therefore, monitoring gastric emptying is an essential part of ICU management, aimed at reducing these risks and making informed decisions regarding nutritional support. We hypothesize that there will be a close relationship between ultrasound of the stomach and aspiration for the assessment of gastric residual volume in patients admitted to the intensive care unit. In a convenience sample of 30 adult patients admitted to the intensive care unit, we will Sequential assessment of gastric residual volume performed first by ultrasound of the stomach followed by aspiration of the stomach contents with the volume of the aspirated fluid measured. Two ultrasound procedures will be performed by two independent intensive care doctors. Aspiration of the stomach contents will be performed by the patient’s bedside critical care nurse immediately following completion of the 2nd ultrasound.