ANZCTR search results

The global healthcare workforce has been described as being in a state of burnout since the global pandemic. Burnout is a three-dimensional condition often resulting from chronic work-related stress, encompassing exhaustion or energy depletion, depersonalisation and a sense of ineffectual accomplishment. The aim of this study is to assess whether a combination of nutritional and herbal intervention is effective in individuals experiencing fatigue associated with burnout but who are otherwise healthy. This 10-week randomised, controlled pilot trial comprises four assessment points: baseline, (Study Clinic 1 ) 1 month later (Study Clinic 2), with the final clinic one month later (Study Clinic 3 ) and a follow up (2 weeks post study clinic 3). The primary outcomes are feasibility and safety measures. Secondary outcomes are burnout severity, measured by the Sydney Burnout Measure (three factors: physical fatigue, behaviours dysfunction, emotional) measured monthly, the Warwick-Edinburgh Mental Well-being Scale (measured monthly), the Fatigue Severity Scale (measured monthly), and a Patient-reported Outcome Measure, such as the Patient Specific Scale (measured monthly).

This project aims to create pilot data to determine associations between MRI images as a clinical measure of MS progress and high quality dietary intake and lifestyle data. It is hypothesised that by using objective measures of disease outcomes using high resolution images obtained on a consistent quality scanner will allow for clearer associations between clinical progress and lifestyle management to be explored.

Malnutrition, sarcopenia, and cachexia are common concerns for patients with pancreatic cancer, causing increased risk of comorbidities and may affect their ability to respond to cancer treatments. This study aims to assess the feasibility and effectiveness of an out-patient dietetics program on nutritional status and quality of life in individuals with pancreatic cancer. Who is it for? You may be eligible for this study if you are aged 18 years or older, you have been diagnosed with pancreatic cancer and you are due to begin your cancer therapy within the next month. Study details You will be assessed by a dietitian within the first month of your treatment. Basic health and nutrition information will be collected including your age, weight, cancer stage and treatment, symptoms impacting your nutrition (such as nausea, vomiting, or treatment side effects), and diet history. Individual nutrition recommendations will be provided to optimise your nutritional intake, which might involve consuming oral nutrition supplements. If you have not started therapy, education will be provided regarding your upcoming treatment and how this might impact your nutrition afterwards. The number of times you will be seen by a dietitian will depend on your nutrition status and how much support you require. You will be requested to complete questionnaires to help us understand your nutritional status, quality of life, and satisfaction with the dietetics program. It is hoped this research will determine that dietary counselling for patients with pancreatic cancer is feasible and acceptable to these patients. This pilot study will assess whether there is potential benefit in delivering this service to a greater number of patients with pancreatic cancer in a larger randomised trial.

ECMO-PROMPT is a trial that focuses on improving the long-term disability, functional status and health outcomes for survivors of ECMO therapy. Providing the results of patient reported outcome measures (PROMs) to patients and their primary care clinicians at hospital discharge and beyond, is an intervention used in other patient groups to support the transition from hospital to home. In this study, ECMO survivors will have PROM monitoring. The intervention group will receive feedback and recommendations.

This research study aims to look at whether physiotherapists working in the Neonatal Intensive Care Unit (NICU) can identify changes in babies’ lungs to the same level as a neonatologist using Lung Ultrasound (LUS) scans. Physiotherapists working in the NICU may provide chest physiotherapy (CPT) to preterm babies to help treat certain respiratory pathologies. Not all preterm babies require CPT and currently physiotherapists use multiple assessment tools to identify appropriate babies in lieu of a single existing Gold Standard measurement tool. Current assessment tools have inherent challenges and are not considered clinimetrically robust. LUS has been suggested as a new physiotherapy assessment tool because of its high level of valid, reliable and feasible lung imaging, that can be performed in real-time by the bedside, without exposing babies to radiation. This project will investigate whether neonatal physiotherapists can reliably interpret LUS scans compared to an experienced neonatologist. Results may allow physiotherapists to use LUS as an assessment tool in the future to help more safely and correctly identify babies who may benefit from chest physiotherapy.

The primary purpose of this study is to evaluate the clinical effectiveness of LUS compared to routine chest physiotherapy outcome measures in determining the need for and effect of physiotherapy on neonates. This will be done by comparing whether LUS is better at guiding CPT treatment than looking at the lungs with CXR and listening to the lungs using a stethoscope. Results may help us improve how CPT is delivered to babies in the future.

The GIFT Trial is a randomised, controlled, blinded, parallel group trial to compare the effect of supplementary pasteurised donor human milk versus infant formula on length of neonatal hospital stay, morbidity, breastfeeding, growth, development and health care costs in clinically well pre-term infants born between 32+0 and 36+6, with a birth weight >=1500g and with insufficient maternal breast milk available. The GIFT Trial hypothesises that the use of donor milk instead of infant formula, as a supplement to maternal breast milk, in moderate-late preterm infants will reduce the time spent in hospital after birth.

The purpose of this study is to investigate whether a short injection of a drug called bevacizumab into the abdominal cavity (known as intraperitoneal infusion) after drainage of excess fluid in the abdomen may delay the return of the ascites compared to an injection of saline only. Who is it for? You may be eligible for this study if you are an adult with symptomatic, cytologically confirmed malignant ascites arising from a solid organ malignancy, excluding pancreatic cancer. In addition, you are either not receiving or not planned to receive additional systemic anticancer treatment for the duration of study treatment. Study details Participants will be randomly allocated to either receive bevacizumab with saline, or saline alone, into the abdominal cavity through an intraperitoneal infusion. This will be followed by a larger infusion of saline over a 30-60 minute period. This therapeutic drainage process may be repeated for re-accumulation of ascites during the study period, if required. Data from participant electronic medical records and quality of life questionnaires will be collected. It is hoped that this research will help demonstrate the potential activity of bevacizumab to decrease or delay the re-accumulation of malignant ascites.

Agitation commonly occurs on emergence from general anaesthesia in adult patients. Our hypothesis is that an orientation message and verbal command will be superior to a verbal command alone. The messages will be delivered via noise-cancelling headphones from cessation of general anaesthesia until the patient opens their eyes.

We are conducting a research study to better understand sleep and mental wellbeing in athletes. Sleep is an essential part of successful training and peak athlete performance. Good quality and adequate sleep are also important to support good mental health and wellbeing. There is not much information about sleep interventions to enhance sleep quality and quantity in elite/pre-elite athletes. Nor is there much information about the way that sleep affects mental health in elite/pre-elite athletes. The aim of this study is to learn more about whether a Cognitive Behavioural Therapy for Insomnia (CBT-I) sleep intervention protocol can improve sleep and mental wellbeing in athletes. We hypothesise that CBT-I will be efficacious for improving sleep quality in healthy athletes.