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Analysis of the effect of a 6 week very low calorie diet (VLCD) on patients at high risk of NASH as shown by changes of liver biopsy, liver biochemistry and CT scan.
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The AustraliaN Trial Investigating Post Operative Deficit, Early extubation and Survival (ANTIPODES)
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A prospective observational study of the effect of a pre-operative 12 week very low calorie diet (VLCD) on liver volume and intra-abdominal fat mass in severely obese patients presenting for obesity surgery.
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Testosterone in Obese Men Trial
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ANZ 02P2 / International Breast cancer Intervention Study: IBIS-II DCIS
Expand descriptionPhase 3 This study is comparing the effectiveness of the drugs tamoxifen versus anastrozole in postmenopausal women with hormone sensitive ductal carcinoma in situ (DCIS). This is an ANZ 02P2/ International Breast Cancer Intervention Study: IBIS-II DCIS. Who is it for? You can join this trial if: You are a postmenopausal woman aged between 40 and 70 years. You must have had DCIS diagnosed in one breast within the last 6 months. The DCIS must have been hormone sensitive and have been locally removed (i.e.not by mastectomy). Trial details Participants will be randomly divided into two groups. One group receives tamoxifen plus a non-active compound in place of anastrozole. The other group receives anastrozole plus a non-active compound in place of tamoxifen. These are taken orally, every day for 5 years. The study aims to compare how effective the two drugs are in preventing and controlling locally any subsequent disease, in the same or the other breast. DCIS has the potential to develop into breast cancer which can spread to other places in the body. Both tamoxifen and anastrozole lower levels of the hormone oestrogen in the body and are used in women already diagnosed with breast cancer. Tamoxifen is used in some women with DCIS for the prevention of breast cancer. This trial is looking at whether anastrozole is as effective as tamoxifen in preventing further DCIS and breast cancer.
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Does a six-week stretching program change the extensibility of the hamstring muscle ?
Expand descriptionRandomised Conrolled Trial looking at effectiveness of 6 weeks of daily 30-minute stretch intervention on hamstring muscle extensibility in able-bodied population
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Isocapnic intermittent hypoxia and endothelial dysfunction
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Interventions to improve participation in bowel cancer screening: the value of lay advocacy and positive framing of risk.
Expand descriptionImproved participation in screening for bowel cancer is desirable. Currently population scale bowel cancer screening program delivery is by mailed offer from a central screening service and invitations include a faecal occult blood detection kit. Invitees may decline the offer because they do not feel they are at risk, or because they do not engage with the program. We have developed invitation letters to that include either improved risk messages or messages from previous screening participants in order to overcome these barriers. We will randomly select invitees from the electoral roll and compare population screening participation between groups with or without the preliminary letter to determine which program results in the greater participation rate. Improved participation in screening will ultimately reduce deaths from bowel cancer
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Craniofacial Deformities in Children - Trial to Understand the Aetiology of Non-syndromic Cleft Lip and Palate
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Pain assessment and management in older people
Expand descriptionThe aim of this project is to test the immediate and long-term effects of a nursing intervention on improving pain of older patients in the hospital setting. A controlled trial will be undertaken in the geriatric evaluation and management units of two metropolitan hospitals. An organisational improvement model underpins the intervention, which comprises an educational program and clinical role modelling. This model considers the complexity of pain management activities in multidimensional ways.