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A phase 1 clinical trial of BDCA-BDC-01, a BDC-1 blood dendritic cell preparation loaded with control and tumour-associated antigens to evaluate the safety of immune therapy in metastatic hormone refractory prostate cancer
Expand descriptionPhase 1 This is a trial of an anti-cancer treatment known as BDCA-BDC-01 which is a preparation of blood dendritic cells (BDC-1 type) loaded with antigens. The treatment is for immune therapy of distant secondary cancer (metastases) of the prostate when this no longer responds to hormone treatment (hormone-refractory). Who is it for? You can take part in this trial if you have distant secondary prostate cancer which has not responded to androgen deprivation therapy (therapy to reduce levels of the hormone testosterone in your body). Trial details Participants receive injections either under the skin or intravenously with a BDC-1 blood dendritic cell preparation which is loaded with special proteins (antigens that prompt the formation of antibodies). This happens once a month for 3 months. The trial aims to induce an immune response against the cancer and assess the safety and effectiveness of this treatment. Dendritic cells are important immune cells which are normally present in the human body. BDC-1 dendritic cells are a type of dendritic cell. Dendritic cells can be prepared with special proteins from the prostate cancer to enhance the immune response. The standard treatment for metastatic prostate cancer that is not responding to androgen deprivation is chemotherapy.
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The correlation between magnetic resonance imaging measured lumbosacral cerebrospinal fluid volume and the sensory block height obtained following spinal anaesthesia in elderly patients
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Improved characterisation of the clinical phenotype of Hereditary Motor Sensory Neuropathy of neuronal type with onset of symptoms in early childhood, especially with respect to disease progression with age and the incidence of such complications as foot deformity, contractures, scoliosis and respiratory involvement - an observational study.
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Botulinum toxin A and the neglected upper limb in children with hemiplegic cerebral palsy
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Upper limb functional assessment in children with hemiplegic cerebral palsy: a descriptive study
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Whole Foods versus Supplements to Reduce Oxidative Stress in the Airways
Expand descriptionThis study examines the ability of oral lycopene supplements (provided in the form of tomato extract capsules and tomato juice) to improve biochemical and clinical markers in stable asthma
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The use of objective measures in assessing driving ability
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Determination of the aspects of driving that occupational therapists believe are amenable to rehabilitation in the form of driving lessons
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Validation of a driving efficacy scale
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Rehabilitation and driving with Multiple Sclerosis
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