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The primary purpose of this study is to determine if daily doses of AOD9604 cause weight loss in obese adults.

Target sample size = 30 subjects for Stages 1 and 2. The primary aim of the study is to determine whether treatment for Obstructive Sleep Apnoea with nasal Continuous Positive Airway Pressure therapy will improve triglyceride metabolism over 24 hours. Triglyceride concentrations in the blood increase after meals and the reduced rate at which they are metabolised is a marker of increased cardiovascular risk. We hypothesise that treatment of sleep apnoea will improve post prandial levels of triglycerides.

This study will determine if high protein, low carbohydrate diets are superior to standard high carbohydrate diets in people with type diabetes.

The purpose of this study is to determine whether the use of adjunctive G-CSF therapy decreases mortality and morbidity in critically ill patients with septic shock. Patients are screened for eligibility to participate in the study. If all inclusion criteria are met and there are no exclusion criteria consent is obtained from the patients or next of kin. Once consent is obtained the ICU pharmacist is contacted and the patient is randomised to receive either G-CSF or placebo once a day for 10 days or until discharge from ICU if that is sooner. Data is collected on a daily basis whilst the patient is in ICU and following discharge from ICU the date of hospital discharge or death is obtained from the hospital patient records database.

Patients who have developed kidney failure in the intensive care unit (ICU) ar being invited to take part in a clinical research study comparing two different types of artifical kidney treatment, which doctors call continuous renal replacement therapy or CRRT for short. The goal of the study is to compare two doses of CRRT. This treatment is also commonly known as continuous dialysis. As it stands doctors are uncertain as to the best level of intensity of treatment with a kidney machine in this setting and wish to do a study comparing two levels of treatment to see which one is best for patients with this condition. If a patient has acute renal failure and they require treatmnet they will still receive one of these treatments because their kidneys are failing. The CRRT two doses are: 1. Continuous renal replacement therapy at 40 ml/kg/hr (about 3 litres per hour) of fluid exchange or 2. Continuous renal replacement therapy at 25 ml/kg/hr (about 2 litres per hour) of fluid exchange. This study will involve 1500 patients from 30 Intensive Care Units in Australia and New Zealand and will include all types of patients admitted to Intensive Care.

Patients had a reduced incidence of vasospasm but the resul was not significant. There was no difference between groupw