ANZCTR search results

This study is a randomised open-label trial of administering an Influenza and COVID vaccine on the same day in the same arm or in opposite arms. We will enrol healthy participants who would like to the get the Influenza vaccine and a COVID vaccine booster on the same day. We will randomise participants to receive the two vaccines to the same arm or to opposite arms on the same day and have blood, saliva and nasal fluid tests to follow their immune responses to the vaccines. partcipants have study visits prior to vaccination, day 6 post vaccination and day 28 post vaccination. We are testing the idea that receiving both vaccines the same arm may provide higher levels of immune reponses against Influenza.

This study investigates the connection between the immune system and dry eye disease, highlighting the significant impact of the gut microbiome on immune modulation and its potential role in chronic systemic inflammation. We hypothesise that probiotics could aid in managing dry eye disease by altering gut dysbiosis and reducing systemic inflammation, suggesting a systematic approach could alleviate symptoms. To explore this, we are conducting a double-masked, randomised controlled clinical trial with participants suffering from mild to severe dry eye. They will receive either probiotics or a placebo for four months, followed by a month of follow-up. The trial aims to assess changes in dry eye symptoms, inflammation levels, corneal nerve health, and systemic microbiome alterations to evaluate the effectiveness of probiotic treatment.

Preschool children with wheeze (PSW) is very common and has higher morbidity than any other asthma group. PSWs very high unmet needs are documented in international parent/end-user surveys. Although many no longer wheeze by 6y, ~40% have recurrences, require hospitalisation and it is not a benign illness. Yet, identifying wheezing is challenging for parents (>50% disagreement between doctors & parents) and many cultures (incl. Indigenous Australians) do not have a word for wheeze. This may cause under- or over-diagnosis of asthma, & lead to over- or underuse of medications, children undergoing unnecessary procedures & high parental anxiety. Giving all children asthma meds is very poor practice as there are adverse events associated with these meds and it is against parents’ wishes. Our multicentre RCT study addresses the need to manage recurrent PSW by objectively defining wheeze using as a bundle (1) an AI-developed tool (WheezeScan, WzS) and (2) a wheeze management plan. Recruiting children from hospitals and community clinics, we plan to recruit 206 children with recurrent PSW including those from our remote Indigenous clinics to determine if this intervention (WzS with management bundle) reduces unscheduled doctor visits (primary aim), and other clinically important outcomes (hospitalisation, time to next unscheduled doctor visit, quality-of life).

Our research focuses on finding new ways to help people with a specific type of eye discomfort known as Sjögren's Syndrome-related dry eye. This condition can cause symptoms like dryness, irritation, and reduced tear production, making everyday activities uncomfortable for those affected. Recent studies have shown the association of the gut microbiome with Sjögren's Syndrome. To explore potential new treatments, we are examining how certain food supplements, called prebiotics and probiotics, might help. This is a double-masked, randomized controlled clinical trial in which 46 participants with Sjögren's Syndrome will be randomized through a web-based randomisation system to receive the probiotic and prebiotic or their placebos treatment for 4 months. Our research hypothesis the application of oral probiotics and prebiotics can improve Sjögren's Syndrome-related dry eye.

The primary purpose of this study is to test the effectiveness of an online single-session intervention (SSI) for reducing binge and disordered eating behaviours by teaching skills and techniques for intuitive eating. It is hypothesized that participants in the immediate intervention group will have decreased binge and disordered eating symptoms at post-intervention compared to participants in the waitlist control group.

This study aims to evaluate the effect of prehabilitation via telehealth (virtually) on reducing hospital length of stay and minimising post-operative complications in patients with abdominal and thoracic surgery compared to face-to-face prehabilitation. We hypothesise that telehealth will be equally effective in improving outcomes, which may strengthen the evidence to support the delivery of prerehabilitation services to remotely located patients who are unable to access hospital facilities.

The specific aims of this prospective observational study are: To investigate the short-term effects of ACTs on ventilation distribution and end-expiratory lung volume in adults with bronchiectasis. To examine the feasibility of EIT to assess the short-term effects of ACTs in adults with bronchiectasis in hospital outpatient clinic settings. To examine the feasibility of EIT to provide clinically meaningful outcomes of ACTs in adults with bronchiectasis. The objectives of this quantitative study are: To document and analyse the changes in ventilation distribution during ACTs in adults with bronchiectasis using EIT. To document the participant’s feedback on the experience of performing airway clearance with continuous EIT measurement. To document the clinician’s experience of using EIT as an outcome measure for ACTs in clinical settings. Study design: prospective observational cohort study using quantitative approaches.

Urinary tract infections (UTIs) are the most common postoperative complication following pelvic organ prolapse surgery. The risk of UTI after incontinence and prolapse surgery has been reported to be 24-33%. This study will see if placing a small amount (50ml) of an antibacterial solution called Microdox when the urinary catheter is removed could decrease the risk of urinary tract infection after surgery. We are comparing this to our current practice, which is to remove the catheter without placing any liquid inside the bladder.

Approximately 30%-40% patients do not respond to biventricular (BiV) pacing for cardiac resynchronisation therapy (CRT). Response to left bundle branch area pacing (LBBAP) also appears to be variable and ranges from no response to super-response. Whether differences in LV activation is responsible for this variable response is unclear. In this study, we aim to evaluate differences ventricular activation in patients with super-response and non-response to LBBAP and BiV-CRT.

This study aims to investigate the adequacy of pre-oxygenation through the techniques identified to be used in a recent survey of clinicians in Australia and New Zealand in healthy children. The results of this study will inform a follow-on study investigating effective pre-oxygenation techniques in critically unwell patients in the intensive care unit and emergency department