ANZCTR search results

Over 1.2 million Australian patients are at risk of experiencing perioperative hypothermia (heat loss to below 36°C) annually, with a cost of over $1.2 billion to the Australian health care system. Perioperative hypothermia is associated with numerous adverse outcomes including increased wound infection, increased blood loss, longer hospital stays, patient discomfort and poor surgical experience. Prevention involves consistent temperature monitoring and appropriate use of warming strategies throughout surgery. However, in Australia, temperature monitoring during surgery occurs in around 20% of procedures and rates of perioperative hypothermia remain high at approximately 27% of patients. Our trial will evaluate practice recommendations and an implementation strategy for sustainable improvement in perioperative hypothermia prevention in Australian hospitals.

This study aims to investigate the feasibility and effect of administering fibrinogen concentrate in the setting of severe traumatic bleeding in the prehospital setting, This is being done to evaluate the possibility of conducting a prehospital arm of the forthcoming FEISTY II study.

The goal of the study is to compare the antigen rapid test results to the corresponding PCR data for overall sensitivity and specificity. Specimens are collected from patients who have COVID-19 like symptoms. Participants are recruited across all genders and eligible age groups. Study staff records participants' information such as symptoms and time since symptom onset. For each study participant, the specimen for RT-PCR is collected first, then for the antigen rapid test. The same group of participants will be included in three arms of the study, one arm is for obtaining data on the Hough COVID-19 antigen rapid home test kit, another arm is for obtaining data on the Coronavirus (COVID-19) antigen rapid test kits, the comparator arm is to obtain data from the RT-PCR specimens. The sensitivity and specificity of the test kits will be determined in relation to the results of the reference PCR test and the day post onset of symptoms. The peak period for detection of COVID-19 infection will be determined. The SARS-CoV-2 variants in the positive samples will be confirmed by the variant-specific RUO assay and sequencing.

This research project aims to: a) To examine the risks of subsequent health complications (determined by ICD-10AM code) in the 12 months following COVID-19, influenza or RSV infection, compared with a control group (no recent evidence of COVID-19 or influenza infection). b) inform Queensland Health about the potential scale of post-viral impacts arising from COVID-19 or influenza, and any system-wide response that may be required. The Project Team is part of the Office of the Chief health Officer in Queensland Health, which accesses the Notifiable Conditions System. The system houses information on COVID-19, influenza and RSV-positive PCRs.

This study aims to evaluate the safety and tolerability of a single ascending dose of CTX310 in patients with refractory dyslipidemias and to determine the recommended Phase 2 dose.

The purpose of the proposed trial is to test an immersive, virtual reality haptic walking (VRHapticWalk) in combination with spinal transcutaneous electrical stimulation (tES) intervention in an effort to restore touch perception among people with discomplete spinal cord injury (SCI). While recognition of surviving pathways in some individuals with a discomplete SCI has tremendous rehabilitative opportunities, currently no effective interventions exist to promote or restore touch perception among these discomplete SCI. The proposed study offers new, exciting diagnostic and therapeutic avenues in complete SCI practice by capitalizing on identification of cases that are discomplete SCI and initiating for the first time sensory/touch rehabilitation. We hopothesise that after 20 sessions of the VRHapticWalk + spinal transcutenous electrical stimulation touch sensation will be restored. For instance, individuals with a discomplete spinal cord injury will experience sensation when someone touches them.

Birthing women experience perineal tears and episiotomy (cutting the vaginal opening during childbirth) that may impact upon a woman's physical, emotional and sexual well being. This study began after the author (who is both a Midwife and an acupuncturist) observed acupressure that she offered to birthing women on the perineal acupuncture point Conception Vessel 1 (CV1) facilitated normal vaginal birth and women were less likely to have severe perineal tears and did not require an episiotomy.

Parental acceptance and insightfulness has been found to be important to the attachment security and social and emotional development of autistic children. However, no research exists relating to developing parental insightfulness and acceptance in parents of autistic children. This study tests the effectiveness, feasibility and acceptability of a novel consumer-informed parent support program through a pilot randomised controlled trial (RCT) of the AutInsight program: a program developed based on insights from autistic adults and what they wanted from their own parents. The program seeks to help parents i) develop greater insight and understanding of autism from the inside out, drawing on the perspectives of autistic adults; ii) strengthen their relationship with their child; and iii) develop practical strategies for parents’ self-care. It is expected that at the end of the program, parents will develop in insightfulness and acceptance of their autistic children, report a better relationship with their child as well as develop greater strategies for self-care.

This study aims to assess the feasibility of making virtual reality (VR) experiences available to palliative care inpatients in a large tertiary hospital. Who is it for? You may be eligible for this study if you are a hospital inpatient admitted directly by the palliative care team, and have a life expectancy of less than 12 months. Study details Patients will be offered a one-off VR experience with a head mounted device (HMD), where they are immersed in different VR environments of their choice. Choices include indoor or outdoor scenes and urban or natural environments. There will be a brief interview afterwards to discuss what they thought about the experience. It is hoped that patients will find this experience enjoyable and that the findings from this study will help elicit the preferences of this patient population with regards to the types of VR experiences they would be interested in, to guide the provision of future VR product offerings.

This study will assess the potential of neurologist videoconferencing to improve the accuracy of paramedic-led transport decisions for hyper-acute stroke. We anticipate that when appropriate the video assessment of patients by a neurologist, at the point of first contact will improve the accuracy of transport decisions. We will introduce this process and support the effort using virtual reality training, which guide paramedics through detailed stroke assessment and transport decision-making workflow. The overarching aim is to enhance paramedic identification of treatment-eligible stroke patients, to support decision-making regarding the most appropriate hospital destination, and thereby reduce treatment times and improve patient outcomes. To achieve this we have co-designed a clinical pathway, protocols and processes to facilitate paramedic point-of-care video conferencing with stroke neurologists. In the current study we will 1) Develop, test and evaluate a new Virtual Reality training platform, to enhance paramedic detection of stroke signs and pre-morbid status, and use of optimal workflow procedures (including videoconferencing) and 2) Determine the impact of i) training on local paramedic staff and their use of the new workflow approach via implementation outcomes and ii) the training platform on accuracy of stroke patient transport destination decisions in a pre-/post-analysis.