ANZCTR search results

Clinical guidelines recommend 6-12 weeks of conservative care for first presentation of rotator cuff related shoulder pain prior to considering imaging or surgery. In contrast, surveys of practitioners conducted by our group identified high rates of inappropriate imaging (up to 82%), inadequate education and highly variable exercise interventions and timeframes. High-quality group interventions for RCRSP have the potential to improve quality of care, patient adherence and clinical outcomes and economic outcomes for this condition. This pilot feasibility and randomised controlled trial will compare a 12-week group exercise and education intervention to i) active control (education only), and ii) usual care.

A decentralised, single-centre, randomised, controlled, clinician, researcher and participant blinded trial with two parallel groups conducted in all states and territories in Australia to determine the effect of removing folic acid from vitamin and mineral supplements for pregnant and lactating women. The study aims to investigate and evaluate the risks and benefits of continued folic acid supplementation so that both mothers and policymakers can make informed decisions during pregnancy.

Heart disease and stroke is accelerated in people with type 2 diabetes. More recently insulin resistance, even in those without diabetes, has been identified as a major driver. People can have insulin resistance, with normal blood glucose levels, for years and be unaware they are at-risk of heart disease and stroke. It is important to identify these people because early intervention can prevent development of type 2 diabetes, heart disease and stroke. The standard clinical assessments are not effective at identifying insulin resistance at its earliest time point. We aim to do a community screen to determine whether the mixed meal challenge (a milk drink with fat, protein and carbohydrate) can identify insulin resistance in the population that would otherwise be undetected using conventional testing. We hypothesise that the mixed meal challenge will be a new low-cost, easy to perform, diagnostic test, forming a necessary and fundamental strategy for the prevention of type 2 diabetes, heart disease and stroke in routine practice.

The aim of the current study was to investigate the utility and efficacy of a single-session, remote, mindfulness-based virtual reality intervention for psychological wellbeing among university students. The novel intervention was compared to two other digital mental health (DMH) modes (i.e., computer and mobile phone) and an active control condition.

Left bundle branch pacing (LBBP) is rapidly emerging pacing therapy. Traditionally, lumenless fixed helix lead is used for LBBP which is delivered through a fixed curve or preshaped flexible curve delivery catheter. Left bundle area can also be captured with implantation of traditional stylet-driven leads delivered with the use of various delivery sheaths from different manufacturers. Currently, both techniques are in use; however, data regarding comparison of outcomes of these two different lead systems is limited. This trial aims at comparing the outcomes of these two different techniques of LBBP which are currently in use.

Nausea and vomiting are common reasons for people to call an ambulance. In Queensland, paramedics can provide a medication called ondansetron to reduce the severity of nausea and vomiting. Alternative medicines, such as metoclopramide and droperidol, are also used in the emergency department or by ambulance services in other states. This study aims to determine the effectiveness of medicines for nausea and vomiting in the prehospital environment. We will randomly assign patients who have nausea and/or vomiting to receive either ondansetron, metoclopramide, droperidol or a placebo as a prehospital treatment. We hypothesise that the proportion of patients experiencing symptom relief will be higher in the 3 medication compared to placebo groups

The aim of this study is to assess the feasibility and accuracy of a novel point of care test to predict foot ulcer healing in people with diabetes. Specifically to define whether a point of care test (InflammaDry) measuring Matrix Metalloproteinase-9 (MMP-9) in wound fluid obtained from diabetes related foot ulcers is feasible when used in a interdisciplinary High Risk Foot Service (iHRFS) and can reflect laboratory MMP-9 measures accurately, so to then predict ulcer healing outcome. Secondary aims are to determine if topical application of a dried human tissue allograft derived from placental membrane (Revita) may improve the healing trajectory of foot ulcers in people with diabetes whose ulcers despite receiving optimized care in a iHRFS are not demonstrating signs of healing. If we can show that we can analyse MMP-9 at the chair-side during consultation at the time of treating the foot ulcer and determine if this test can predict healing outcomes, then in the future we could make a timely decision at the same patient consultation in the interdisciplinary High Risk Foot Service to apply intensified therapy such as Revita® treatment. Together these studies will determine whether these MMP-9 POCT is feasible, if other biomarkers can in a complementary manner, predict the healing outcomes, and whether the Revita® treatment is well tolerated and could improve wound healing in people with delayed wound healing in diabetes.

The global healthcare workforce has been described as being in a state of burnout since the global pandemic. Burnout is a three-dimensional condition often resulting from chronic work-related stress, encompassing exhaustion or energy depletion, depersonalisation and a sense of ineffectual accomplishment. The aim of this study is to assess whether a combination of nutritional and herbal intervention is effective in individuals experiencing fatigue associated with burnout but who are otherwise healthy. This 10-week randomised, controlled pilot trial comprises four assessment points: baseline, (Study Clinic 1 ) 1 month later (Study Clinic 2), with the final clinic one month later (Study Clinic 3 ) and a follow up (2 weeks post study clinic 3). The primary outcomes are feasibility and safety measures. Secondary outcomes are burnout severity, measured by the Sydney Burnout Measure (three factors: physical fatigue, behaviours dysfunction, emotional) measured monthly, the Warwick-Edinburgh Mental Well-being Scale (measured monthly), the Fatigue Severity Scale (measured monthly), and a Patient-reported Outcome Measure, such as the Patient Specific Scale (measured monthly).

This project aims to create pilot data to determine associations between MRI images as a clinical measure of MS progress and high quality dietary intake and lifestyle data. It is hypothesised that by using objective measures of disease outcomes using high resolution images obtained on a consistent quality scanner will allow for clearer associations between clinical progress and lifestyle management to be explored.

Malnutrition, sarcopenia, and cachexia are common concerns for patients with pancreatic cancer, causing increased risk of comorbidities and may affect their ability to respond to cancer treatments. This study aims to assess the feasibility and effectiveness of an out-patient dietetics program on nutritional status and quality of life in individuals with pancreatic cancer. Who is it for? You may be eligible for this study if you are aged 18 years or older, you have been diagnosed with pancreatic cancer and you are due to begin your cancer therapy within the next month. Study details You will be assessed by a dietitian within the first month of your treatment. Basic health and nutrition information will be collected including your age, weight, cancer stage and treatment, symptoms impacting your nutrition (such as nausea, vomiting, or treatment side effects), and diet history. Individual nutrition recommendations will be provided to optimise your nutritional intake, which might involve consuming oral nutrition supplements. If you have not started therapy, education will be provided regarding your upcoming treatment and how this might impact your nutrition afterwards. The number of times you will be seen by a dietitian will depend on your nutrition status and how much support you require. You will be requested to complete questionnaires to help us understand your nutritional status, quality of life, and satisfaction with the dietetics program. It is hoped this research will determine that dietary counselling for patients with pancreatic cancer is feasible and acceptable to these patients. This pilot study will assess whether there is potential benefit in delivering this service to a greater number of patients with pancreatic cancer in a larger randomised trial.