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Bridge to Better Health aims to improve preventative health actions to people with intellectual disability. The project intervention will support practice nurses at General Practices by providing educational resources and access to a specialised disability nurse to assist in facilitating health assessments. We will collect quantitative data from medical and hospital records in order to explore changes in preventative health actions, and potentially avoidable hospitalisation for people with intellectual disability. Qualitative data will be in the form of interviews/surveys for practice nurses/staff and people with intellectual disability to understand their experiences either completing the health assessment or being the patient during the intervention. Expected outcomes are an increase in preventative health actions for people with ID; a decrease in potentially avoidable hospitalisations for people with ID; an increase in practice nurses' knowledge, attitudes and confidence towards patients with ID.

This double blind, placebo controlled, first-in-human (FIH) study will assess the safety, tolerability, PK, PD, and immunogenicity of TX000045 in healthy men or women of non-childbearing potential. This study will establish doses of TX000045 that are safe, well tolerated, and exhibit appropriate PD effects to warrant further clinical investigation. Who is it for? You may be eligible for this study if you are a healthy adult aged between 18 and 55 years old. Approximately 75 healthy participants will be enrolled in the study. The duration of participation in the study is approximately 3 months (inclusive of a 27-day screening window, 1-day baseline period, and a 57- day follow-up period after dosing) across 6 cohorts of 8 participants each. The study will be conducted in 2 parts, as follows: • Part A: single ascending doses • Part B: repeat single 150 mg SC dose cohort In Part A, each participant will receive a single dose of TX000045 or matching placebo, randomized in a 3:1 ratio per cohort, via at least a 30-minute intravenous (IV) infusion or subcutaneous (SC) injection. In Part B, each participant will receive repeat single 150mg SC doses of TX000045 or matching placebo randomised in 3: 1 ratio administered on Days 1.

consumers prescribed Clozapine suffer from constipation; essentially double that of the general population. Clozapine consumers are 3 times more likely to develop constipation, compared to their contemporaries prescribed other antipsychotics. Ongoing questioning and screening by mental health professionals is strongly recommended, in order to detect and treat constipation in a timely manner. In my experience as a mental health case manager, and more recently as a Clozapine coordinator, the screening, detection, and management of clozapine induced constipation is severely lacking. Non-pharmacological interventions are considered the first and most important step in managing constipation. One hour of exercise, five days a week; increased fibre and fluid intake. These can be achieved with minimal support clinically, and financially. Clozapine clinics have been seen as a place to develop health agency and providing education during clinics, with a view to have the consumers engage in their own treatment interventions for constipation would be the goal. I would aim to incorporate the peer workforce and current consumers prescribed clozapine in the development of the education aspect. This RCT will consist of a control and intervention group. The control group will receive current health practices, which include 3 monthly screening and assessment for constipation by a registered nurse and /or physician. The intervention group will receive an hour of education, targeted at improving their knowledge and understanding of constipation, and given them lifestyle interventions to manage it. All participants will complete a 2 weekly constipation self-report measure called the PAC - SYM to collect data.

Atrial fibrillation (AF) is a complex heart rhythm disease. We have shown the utility of a multi-disciplinary approach for patients with AF, but applicability in real world settings with poor health literacy and unmet social needs is unknown. We hypothesize that a precision health platform can deliver integrated care in AF successfully. Therefore, we test a precision health model of care focusing on patient empowerment and self-management by promoting critical health literacy and personalised medicine utilizing a Precision Health Platform (Precision AF App). This novel approach moves away from a resource intensive multi-disciplinary approach and emphasizes health behaviour change to achieve the comprehensive AF management.

Diabetes-Related Foot Ulcers are common in people living with diabetes and are a major cause of poor quality of life and disability. If they are not treated appropriately they may require hospitalisation and could lead to amputation and early death. Right now, we don’t have a quick and simple way to know which ulcers will heal normally, and which ones may delay healing, or lead to amputation. This project will trial a new way to analyse photography known as thermal imaging to see if there is extra information in this sort of image to help predict which ulcers will heal and which ones may not, so we can know which ulcers may need more aggressive intervention so they are more likely to heal.

Purpose of the study: The aim of this study is to investigate whether a structured physical activity program undertaken following chemotherapy can improve physical fitness and heart function in acute leukaemia patients. The results of this study will be used to guide future care for acute leukaemia patients. Who is it for? You may be eligible to join this study if you are aged 18 years and above and can exercise at the time of enrolment. Study details: Participants will undergo a series of assessments prior to the beginning of the study and again at 12 weeks later. Participants will perform three exercise bouts per week which will be supervised by the study physiotherapist or exercise physiologist. They will also be given a wearable device which is used to monitor heart rate which can then be used to prescribe exercises. These study activities will be included along with the normal care from the doctors. It is hoped that this study will help determine whether exercise can assist in increasing the physical fitness and quality of life of adults with leukaemia.

Nasally inhaled isopropyl alcohol (IPA) is readily available and an easy-to-administer intervention, that has been shown to reduce nausea and vomiting in patients presenting to the emergency department. The purpose of this trial is to determine the effectiveness of inhaling IPA in reducing nausea and vomiting in the self-ventilating ICU patients. It is hypothesised that nasally inhaled IPA reduces the requirement for intravenous ondansetron in critically ill patients with nausea and vomiting.

This study aims to determine if performing strength training in simulated altitude can cause greater improvements in muscle strength and muscle size in older adults, compared to traditional strength training at sea level conditions. The study ultimately aims to help slow the progression of muscle weakness and muscle wasting in older adults. We hypothesise that performing strength training in simulated altitude (termed hypoxia) will enhance the muscle training responses compared to training at sea level.

Haemodialysis cleans the blood and replaces some of the function of the kidneys when they are no longer working. Patients undergoing haemodialysis have traditionally been prescribed diets low in fruits and vegetables and high in animal protein, sugar and fat to prevent malnutrition and limit dietary potassium and phosphate. Research has shown that healthy diet patterns high in fruits, vegetables, nuts and legumes, and lower in meat and processed food are associated with lower risk of death in those with early stages of kidney disease, however studies examining these outcomes for haemodialysis patients are sparse. The aim of the study is to examine the extent to which healthy diet patterns and meeting core food requirements occur in our patients requiring haemodialysis and follow up participants for up to 5 years for heart disease related events. The study will use a questionnaire to collect information on dietary intake from patients undergoing haemodialysis. Data will be examined for diet quality by food groups and assessed against healthy diet criteria.

Strive to Thrive was created by people with a lived experience of stroke, clinicians and researchers. It is designed to help people who have had a stroke identify what helps and hinders them at their work and create a personalised action plan to manage the impact of the stroke on their day-to-day work life. We want to see if Strive to Thrive is acceptable to a broader group of people who have had a stroke, and make further adjustments and improvements based on their feedback. If Strive to Thrive is acceptable and seen as useful, we can then do a larger study to find out if it has a positive effect on the person who has had a stroke.