ANZCTR search results

This project involves consumption of two mixtures of herbs and spices by overweight and obese subjects for a period of six months. Body composition, body weight, blood pressure and blood lipid levels of the subjects were measured throughout the study (baseline, 3 months and at 6 months) to investigate the effects of the mixtures on these health outcomes.

This study is trialing a digitally enabled model of care to improve glycaemic outcomes in people with type 2 diabetes. The digital tools will enable remote monitoring of diabetes related measures, provide contextual feedback through SMS, easier communication with healthcare professionals and earlier identification of individuals that need enhanced care. It is hypothesized that digital tools for remote monitoring that provide contextual feedback to patients and smart monitoring by healthcare professionals will improve self-management leading to improved glycaemic profile and efficient diabetes care. We will use the REMODeL primarily to: A1: examine glycaemic outcomes in people with type 2 diabetes (T2DM) at 6 months. Assess the impact of REMODeL model of T2DM care pathway on: A2: glycaemic control at 12 months and blood pressure and lipids A3: diabetes distress, patient self-management A4: did-not-attend rates and earlier discharge to primary care. A5: attendance rates at diabetes specialist clinic outpatients, emergency department and hospital admissions A6: healthcare delivery cost and the cost-effectiveness of this model of care

The purpose of this study is to assess the effect of adding channels to scleral contact lenses upon corneal tissue swelling and tear flow behind the contact lens in young healthy adults during short-term lens wear (6 hours). The null hypothesis is that the incorporation of scleral lens channels will have no significant effect upon the primary outcome measures.

This project will investigate the effects of exercise with blood flow restriction on sensitivity to pain and subsequent physical performance. It is hypothesised that the application of blood flow restriction during low volume resistance exercise will reduce pain perceptions whilst maintaining subsequent physical performance. The data will inform best practice for treating athletes suffering from pain due to musculoskeletal injuries in a sporting context.

Safewards is a model that was developed in the United Kingdom for use in mental health inpatient services. The model is based on training staff, and giving staff the resources, to implement 10 psycho-social interventions that allow staff to reduce resident distress, agitation and anger. By doing so, the interventions reduce escalation of conflict between staff and residents, and in reducing conflict, there is a reduction in the use of restrictive practices, such as the use of physical restraint. The study we are undertaking is testing if the Safewards model is effective in residential aged care.

Children with cerebral palsy (CP) participate less in physical activity and have high levels of sedentary behaviour compared to children without CP. In this research we will conduct a mixed methods randomised controlled trial called Active Start Active Future with families who want to support their child’s physical activity participation and consider their own physical activity. We are aiming to determine whether Active Start Active Future is effective in changing the amount of physical activity, physical activity participation and reduce sedentary time for the child at home, in the community, preschools and schools. We will ask parents about their understanding and beliefs around physical activity and sedentary behaviour for their child with CP, explore the parents’ own physical activity behaviours, and explore ways they can support their child be more active. Our aim is to recruit 40 children aged 3-7 years with CP in Gross Motor Function Classification System (GMFCS) levels II-V inclusive of children who need gait aids for mobility or do not walk. We will conduct a physical activity behaviour-change intervention once a week, for 8 weeks face-to-face (with telehealth opportunities if requested). Our trial is innovative because it intervenes earlier in the development of sedentary behaviour and will be one of the first studies to include children who cannot walk independently. The intervention is grounded in evidence-based theories of health behaviour change, individualised for each family, and will be delivered by a paediatric physiotherapist or occupational therapist. Anticipated benefits include gaining a greater understanding of physical activity participation in young children with CP and mechanisms to help change behaviours.

We intend to measure the effectiveness of psychedelic assisted medicines (methylene dioxy methamphetamine - MDMA) when combined with talking therapy; for the treatment of Post Traumatic Stress Disorder in real world patient groups We will test how effective MDMA is for PTSD and treat patients who have had limited benefits with existing treatments for these hard to treat conditions.

We intend to measure the effectiveness of psilocybin when combined with talking therapy for the treatment of Treatment Resistant Depression (TRD) in real world patient groups We will test how effective psilocybin is for TRD and treat patients who have had limited benefit from existing treatments for these hard to treat conditions

Patients with malignant pleural effusion (MPE) and their carers report high rates of unmet supportive care needs. Multi-disciplinary interventions, specifically addressing nutrition, targeted physical activity counselling, and psychological support are recommended by international guidelines for advanced cancer. This study aims to find out if integrated supportive care involving nutritional, physical activity, and psychological well-being care plans can improve participation in daily physical activity in people with MPE. The study also aims to find out if this multidisciplinary counselling can improve quality of life, malnutrition risk, psychological well-being, and symptoms. Who is it for? You may be eligible for this study if you are aged 19 years or older, and have been diagnosed with a malignant pleural effusion and you are willing to comply with the research procedures. Study details Participants who choose to enrol in this study will be randomly allocated by chance (similar to flipping a coin) to one of two groups. The first group will take part in the integrated supportive care program. This program lasts for 12-weeks and includes counselling sessions in week 1, week 4, and week 8. Each counselling session will take about one hour to complete. This includes about 20 minutes each for dietetics, physical activity, and psychological well-being. The second group will will receive standard medical care as per attending physician, with referral to supportive services if indicated. This group will be called by a member of the research team at week 4 and week 8 to discuss any adverse events that have happened to you. Both groups will receive standard medical care from their treating physician throughout the study, including access to support services.

Dizziness is a common but poorly defined condition in people, particularly those over 50 years old. In people 50 years or older, the self-reported prevalence of dizziness and vertigo is over 34 percent. The impact that dizziness and vertigo can have on people over 50 is very relevant as it’s linked with conditions such as isolation, depression, reduced self-autonomy and self-control. It can hamper the social, functional, and psychological well-being of those experiencing dizziness and vertigo which in turn, can reduce quality of life. The trial aims to examine the efficacy and safety of the Chinese formula for preventing and treating dizziness.