ANZCTR search results

This study will use a two-stage, mixed-methods design. Stage 1 will involve co-designing a tailored sleep intervention for the Geriatric and Rehabilitation Unit (GARU) using the Double Diamond framework, followed by a 2-week Plan-Do-Study-Act (PDSA) cycle to refine the intervention. Stage 2 will comprise a 4-week feasibility and acceptability trial, with mixed-methods evaluation of protocol adherence, sleep outcomes, and stakeholder feedback.

Perinatal depression and anxiety affect 1 in 5 Australian mothers and costs the Australian health care system in excess of $877 million annually. Social support has been consistently shown to (a) assist women in meeting challenges in the postpartum period, (b) reduce postpartum depression, and (c) counteract both postpartum anxiety and stress. The aim of this pilot RCT is to evaluate the feasibility, acceptability, and preliminary effectiveness of an online social support intervention aimed at improving the mental health of first-time mothers.

The Sonas Programme is a structured, multisensory group intervention designed to enhance communication and well-being in people with dementia. It includes activities such as music, singing, touch, and sensory stimulation delivered in a supportive environment. This study aims to evaluate the feasibility and cultural relevance of a culturally adapted Sonas Programme in one or more multicultural aged care settings in Australia. We hypothesise that the adapted programme will improve residents’ engagement and quality of life.

Our project aims to enhance the prescription and delivery of exercise to people with type 2 diabetes and long-COVID symptoms (e.g., breathlessness, fatigue) to allow return to, or uptake of, regular exercise. Mirroring the structure of the current Medicare-subsidised type 2 diabetes group exercise scheme, we will examine the feasibility and preliminary efficacy of a long-COVID symptom-guided exercise program after eight weeks.

We aim to assess the effect of two types of individualised education and exercise programs to determine if they can improve neck disability in people with chronic neck pain. Both groups will receive between 2-8 one-on-one treatment sessions with an allied health clinician via telehealth. The study design will be a nation-wide randomised controlled trial. The primary outcome is neck disability at 12 weeks. Cost-effectiveness of the treatments will also be evaluated.

This study aims to evaluate whether the ElectroPulse PFA System (which delivers energy to scar areas of the heart tissue causing abnormal rhythms, so the heart beats normally again) is a safe and effective treatment for people with atrial fibrillation (AF), a common heart rhythm disorder. The results will help support global regulatory approval of the system.

The safety, efficacy and Pharmacokinetics of PTC844 tablets will be assessed with multiple doses over a period of 14 days followed by a single dose. This will be a randomised, double-blind study in healthy volunteers taking standard meal..

This trial is a treatment specific appendix in a modular component of the Precision Therapies in Monogenic Epilepsies (PRIME) master protocol, for a series of N-of-1 studies of precision therapies in monogenic epilepsies. It uses a within-participant, controlled, multi-crossover design to test the hypothesis that Riluzole, a blocker of the neuronal persistent sodium current, improves seizure frequency in individuals with SCN8A-DEE caused by gain-of-function (GoF) variants in the voltage-gated sodium channel alpha subunit 8 gene SCN8A. Plain English summary: This study tests whether the drug riluzole can reduce seizures in people with SCN8A developmental and epileptic encephalopathy (SCN8A-DEE) caused by gain-of-function changes in the SCN8A gene. Each participant will try both the drug and a placebo at different times, so their own results can be compared directly.

Primary aim of this research is to evaluate the impact of the Supportive Care in Chronic Disease (SCCD) model on health service utilisation and consumer experience among patients with liver disease, heart failure, Parkinson’s disease, motor neurone disease, chronic obstructive pulmonary disease, and for patients within the Integrated Chronic Care for Aboriginal People Programs (ICCAPP), with a prognosis of 2 years or less, and their carers.

The primary aim of the project is to evaluate the implementation, effectiveness and acceptability of using an immersive Virtual Reality (VR) pain education program at Queensland’s tertiary adult persistent pain management services. It is hypothesized that the use of a Virtual Reality based pain education program will an acceptable and helpful treatment option to improve outcomes for people with chronic pain.