ANZCTR search results

Shoulder pain is the third most common musculoskeletal complaint managed by general practitioners (GPs) in Australia, with rotator cuff–related shoulder pain (RCRSP) being the most frequent presentation. Despite clinical practice guidelines recommending education and exercise for the management of RCRSP, these approaches are poorly implemented in routine care. This problem is further exacerbated in rural and remote communities, where access to care is limited. There is therefore a need to develop convenient, low-cost, and accessible strategies to support people with RCRSP. The INTEL trial aims to determine the effectiveness of adding internet-delivered care, with or without telehealth, to usual care for reducing pain and disability at 12 months post-randomisation in people with RCRSP. The trial will also compare the cost effectiveness of each treatment from a healthcare perspective and societal perspective (including absenteeism) over 12 months.

This study will compare the bioavailability and biological effects of generic oral rapamycin with a sublingual (under-the-tongue) rapamycin formulation in healthy adults aged 30–60 years. Participants will be randomised to receive a single 6 mg dose of either oral or sublingual rapamycin. Blood samples will be collected at multiple time points over 72 hours to assess the bioavailability of rapamycin. Sirolimus blood concentrations and changes in immune-related gene expression, including pathways related to mTOR signalling, will be measured. The findings will determine whether sublingual administration improves rapamycin bioavailability and molecular response compared with standard oral dosing, informing future clinical research on rapamycin use for healthspan and longevity.

The primary purpose of this study is to determine the safety and immunogenicity of one and two doses of DCO1 at different adjuvant and alum doses. This will be a phase 2 randomised observer blinded trial which aims to help be better prepared for a potential influenza pandemic.

The primary purpose of this study is to determine the safety and immunogenicity of one and two doses of DCO1 at different adjuvant and alum doses. This will be a phase 1 randomised observer blinded trial which aims to help be better prepared for a potential influenza pandemic.

This project aims to evaluate the efficacy of a parent-supervised app-based assessment and intervention program for delivery speech pathology services to children with speech sound disorder (SSD) while they are waiting for standard pathology services. The innovation is in using the program with children on a waiting list. It has been found efficacious in previous studies with children already receiving standard speech pathology services. Primary expected outcome is a new effective approach to managing the chronic shortage of speech pathology services in Australia for children with SSD. Significant benefits will be realised through children accessing low cost speech therapy earlier. The study has two secondary aims. First, we will also test the robustness of our automated speech analysis algorithms for assessment of children’s speech, which has the potential to reduce the time/cost burden of manual speech assessment by speech pathologists. Second, we will explore whether videos of upper body (including face and hand movement) provide insights into how motor control of face and hands changes as speech accuracy increases with treatment.

Reduced neck strength is a risk for concussion in some sports. This study will evaluate the effectiveness of a cervical strengthening and stability program against a control group. We hypothesise that the intervention program will significantly increase strength compared to the control group.

This study evaluates the safety and effectiveness of MiSaver, a cell-based product, in patients who have had a heart attack. MiSaver is designed to help improve heart function. Early research suggests it may enhance heart pumping ability with an acceptable safety profile. The study hypothesizes that MiSaver is safe and improves heart function after a heart attack.

This prospective, open-label, multi-centre national randomised controlled trial (RCT) will assess strategies for methotrexate (MTX) dose reduction and discontinuation in children with nonsystemic juvenile idiopathic arthritis (nsJIA) in stable, minimally active disease, defined as clinically inactive disease (CID) or low disease activity (LDA). The primary outcome is disease flare; secondary outcomes include recapture rates, time to recapture, Wallace Criteria, JADAS71, ACR core variables, and patient-reported measures (JAMAR, CHAQ, PROMIS-25, EQ-5D-Y-5L). The trial also incorporates biospecimen collection and data linkages via the A3BC Registry & Biobank, qualitative research, health economic analysis, exploration of lived experiences, and predictive model development. Participation offers patients, families, and clinicians enhanced support and a structured environment to collaboratively assess flares. Findings will inform treatment decisions and improve care pathways for children with JIA.

It is important while trying to understand the effect of vitamins on the ocular surface and their association with dry eye disease, to try first to characterize the most effective chemical forms of vitamins, utilizing the proper methodologies and supplements with randomized controlled clinical studies. This PhD aims to explore the role of vitamin B12 oral consumption on corneal health and dry eye disease. These findings may in the future guide the development of novel treatment strategies for dry eye disease management.

Brief description of the study purpose: This study aim to identify preferences, barriers, and facilitators for engaging in exercise among women who are diagnosed with breast cancer (or undergoing treatment) and are pregnant / within 18 months of giving birth. Who was it for? This study was eligible for a woman aged 18 years and older diagnosed with breast cancer during pregnancy or within 18 months postpartum in the past 5 years. All participants completed the Exercise and Sport Science Australia (ESSA) pre-exercise screening and obtained medical clearance. Study details Participants who enrolled in this study underwent semi-structured interviews to explore their exercise history, preferences, and the barriers and facilitators influencing physical activity during pregnancy, postpartum, and cancer treatment. Participants were then offered an 8-week supervised online exercise program delivered via Microsoft Teams, consisted of both aerobic and resistance training. Baseline assessments included anthropometrics, functional tests (2-minute step test, chair rise, and 30-second push-up), and quality of life using the EORTC QLQ-C30, with follow-up testing completed 3–5 days after the program. The result from this study helped to investigate the feasibility of running an exercise intervention with this population, and how it affects quality of life, strength, and functional physical capacity.