ANZCTR search results

What the study is about: This study will evaluate whether surovatamig, a novel CD19 × CD3 bispecific T-cell engager, can improve outcomes for people with previously untreated, limited-stage nodal follicular lymphoma (FL). The trial will compare surovatamig with the current standard of care: involved-site radiotherapy (ISRT) with or without rituximab. The aim is to determine whether surovatamig can produce deeper and more durable responses, reduce the risk of disease relapse, and improve event-free survival. Who is it for: This study is for adults aged 18 years or older who have: 1. Histologically confirmed classical follicular lymphoma (Grade 1–3a), Ann Arbor stage I or II nodal, non-bulky disease ( less or equal to 7 cm) 2. PET-positive, measurable disease 3. No prior lymphoma-directed therapy Study details: This is an international, Phase III randomised clinical trial. Participants will be randomised 1:1 on either Surovatamig (6 doses over 12 weeks using a triple step-up dosing schedule) or to the standard of care treatment (Involved-Site Radiotherapy (24 Gy) with or without 6 doses of rituximab, according to each site's predefined standard). Participants will be followed up for 10 years after treatment to assess long-term outcomes. A total of 168 participants will be enrolled across Australia, New Zealand, the United Kingdom, Ireland and Nordic countries. Of these, 60 participants are expected from Australian and New Zealand sites. What is hoped from it: If successful, surovatamig could represent a new standard of care for patients with early-stage nodal follicular lymphoma that is highly effective, well-tolerated, non-radiation frontline option for patients with limited-stage FL.

The CAMAS study is a prospective, longitudinal observational cohort study examining the effects of long-term anaerobic exercise on myocardial structure and function. Adults with predominantly anaerobic gym training are compared with individuals undertaking predominantly aerobic exercise using cardiac magnetic resonance imaging (CMR) and electrocardiography. Blood samples are collected for exploratory molecular analyses where funding permits. Participants are followed annually for up to ten years to document cardiac diagnoses and cardiovascular events. The study aims to identify imaging-based phenotypes associated with anaerobic exercise and potential cardiovascular risk.

This study aims to determine the feasibility of implementing strategies (PTX Implementation Strategy Tollkit) designed to encourage physiotherapists to use recommended sets of exercises (via freely available online software: physiotherapyexercises.com - PTX) and to provide patients with copies of their exercises. This study is a pilot study for a larger, nationwide trial that will test the effectiveness of the PTX Implementation Strategy Toolkit to promote the use of PTX to promote physiotherapists to (i) use recommended sets of exercises available through the PTX software, and (ii) provide patients with copies of their exercises.

The aim of this study is to see if the detrimental cognitive effects of 36 hours of sleep deprivation can be offset by applying slow wave oscillations induced by non-invasive brain stimulation to mimic the effects of slow wave sleep. The study will target healthy adults. Effects will be compared to sham stimulation and a brief nap. It is hypothesised that slow wave brain stimulation will protect the brain from the detrimental effects of sleep deprivation, and will provide similar benefits to that provided by a brief nap.

This study will enrol participants 6 months of age through age 13 with molluscum contagiosum (MC) across up to 6 sites in Australia. Participants will be randomly placed into one of two groups in a 2:1 ratio. This means twice as many children will receive the study treatment (Zabalafin Hydrogel) compared with those who receive the placebo. The purpose of the study is to see how well Zabalafin Hydrogel 9.5% works and how safe it is when used twice a day to treat MC. The main goal is to find out how many participants have more than 75% of their MC cleared by Week 16.

There is evidence that the deepest form of sleep, slow wave sleep, may be a critical target for maintaining cognitive function and reducing the risk of developing Alzheimer’s disease. One way deep sleep may affect the risk of Alzheimer’s disease risk is by helping the brain and body clear out chemicals. We aim to test whether improving deep sleep using an at home EEG device helps with this clearance, and explore what health and lifestyles factors might influence the results, including brain toxin and volume level as measured using MR-PET scans..

People with highly variable sleep apnoea from night to night have different underlying breathing and airway characteristics compared to people whose sleep apnoea is more stable. Detailed in-lab measurements across several nights can explain why sleep apnoea severity changes so much for some people but not others.

Recently, a monitor called the Newborn Infant Parasympathetic Evaluation (NIPE) has been used to study pain in children under 2 years of age, as it assigns a numeric value to the pain response. It does this by analysing the variability of the heart rate, and studies have shown that it accurately tells us when the child is reacting to pain during surgery. Newborn babies undergo a range of painful procedures while hospitalised, including major surgery and minor procedures. These procedures can be distressing to the child and the child's carers, and thus it is important to ensure that we accurately recognising and treating the pain these can cause. Additionally, some newborns experience a severe condition caused necrotising enterocolitis (NEC), which can be treated by stopping feeds and administering antibiotics. However, in some cases this needs to be escalated to surgery. Our study aims to better understand the pain experienced by children who undergo major surgeries and minor procedures, and to observe what causes and helps their pain. Additionally, our study aims to investigate whether babies with NEC who experience more pain are more likely to progress to requiring surgery to treat their condition.

To compare the outcome of daily intermittent intravenous dosing of ceftriaxone verses continuous intravenous infusion of cefazolin by looking at treatment duration in patients admitted with cellulitis to the CHQ at Home’s Hospital in the Home program from 1st of January 2020 to 30th of June 2024.

This study will evaluate an evidence-based online relationship program in an Australian context with individuals experiencing difficulties with alcohol or substance use, and dissatisfaction in their relationship with their intimate partner. The project will address major limitations in the AOD sector by taking a relationship science approach to address relationship dysfunction and breakdown in those couples where at least one partner is affected by substance misuse. Given that the OurRelationship program has already been shown to be highly effective in the wider community, the aim of this proposed project is translational in nature; specifically targeting individuals in the community who have unmet needs regarding problems in their relationships in the context of problematic substance use. It is expected that the application of the OurRelationship program to this section of the community will enhance their relationship functioning, confidence, stability, and quality, and reduce partner conflict and dysfunction.