ANZCTR search results

The proposed project further extends our systematic efforts to understand the relationship between symptoms of anxiety and depression, and daily actions (i.e., thoughts and behaviours - "Things You Do"). The primary objective of this trial is to compare the effects of restricting and then resuming the Things You DO (TYD). The research design is a parallel group randomised controlled trial. Participants (n = 60) will be Australian adults assigned to either the intervention group (behaviour restricted and then resumed) or a control group. Based on our earlier studies, the primary hypothesis is that restricting and then increasing the frequency of TYD actions will result in significantly greater increases and then reductions in symptoms of anxiety and depression, relative to a control condition.

The overall objective is to test the efficacy of co-designed immersive virtual reality-based nature exposure to reduce psychological distress for inpatients in hospital rehabilitation, and understand how this might be implemented and adopted in a clinical setting. We propose a fully powered randomised controlled trial and process evaluation. We hypothesise that exposure to the virtual nature will significantly reduce symptoms of psychological distress compared with the control group which will complete standard care (with no or extremely limited access to nature).

This study aims to investigate the therapeutic appearance, nutritional content and participant acceptability of a sham dietary prescription in healthy individuals. The intent of the sham diet is to have the appearance of a therapeutic diet by excluding or substituting inert food items without altering overall nutrient intake compared to habitual diet. The sham diet has been designed for future use in placebo-controlled dietary advice trials for ulcerative colitis.

To address the dearth of social media training opportunities for health promotion and public health professionals, we intend to evaluate the impact of a MOOC that aims to improve their knowledge and understanding of how to effectively frame health promotion messages and increase their perceived confidence in using social media for health promotion communication and advocacy. A mixed-methods approach, incorporating quantitative pre-and post-surveys and qualitative structured individual interviews, will be used to gain a deeper understanding of both the immediate and long-term effects of the MOOC on various outcomes.

This study aims to assess whether vaginal swabs self-collected using the Abbott simpli-COLLECT kit and self-collected urine samples using the Novosanis Colli-pee device have similar clinical performance detecting HPV associated with cervical disease, compared with the reference practitioner-collected cervical samples. Who is it for? You may be eligible to participate in this study if you are a female aged 25 or above, and has colposcopy referral based on abnormal result of a test within the cervical screening program.. Study details All participants in this study will attend a single clinical appointment, during which time they will be asked to take two self-collected samples, one using a swab to collect a vaginal sample, and the other being a urine sample, and compare them against the standard of care clinician- collected specimen from the cervix for the detection of Human Papillomavirus (HPV) using any colposcopy biopsy findings as the reference for sensitivity and specificity for cervical disease. It is hoped that the results from this study will identify a new option for people wanting to participate in cervical screening.

This trial will be assessing Immune-12 as an adjunct treatment to standard care for GBM. Who is it for? You may be eligible to join this study if you are aged 18 years old or above and have a diagnosis of Glioblastoma multiforme (GBM). Have had magnetic resonance imaging (MRI) of their tumour/s within the 4 months prior to Screening Visit. Have a Karnofsky score of equal to or greater than 50 and ability to swallow liquids (Naso-gastric feeding tubes are allowed). Study details All participants who choose to enrol in this study will be asked to take 2 sachets of Immune-12 twice a day for 24 weeks. Participants will be regularly assessed throughout the study for tumour measurement, potential biomarkers, blood markers, quality of life and functionality, steroid usage, inflammation and oedema, and adverse events. It is hoped that the IMMUNE-12 will help reduce disease progression, tumour growth and potential reoccurrence.

We hypothesise that when Aboriginal Health Workers (AHWs) and practitioners (AHPs) are trained to offer point of care ultrasound scan to detect fetal heartbeat, it will encourage Aboriginal women to engage in the antenatal care process earlier and thereby improve pregnancy outcomes. Therefore, the overarching goal of the proposed pilot study is to improve prenatal care in Aboriginal Torres Strait Islander women in rural Australia through upskilling AHWs and AHPs in one Point of care ultrasound antenatal module. To ensure that the training program meets the needs of the community, a co-design process will be used for development of the educational program and training materials as well as recruitment of participants.

We aim to determine if a 6-session course of reconsolidation blockade (i.e., oral propranolol treatment combined with script-driven trauma recall) is efficacious in reducing PTSD symptom frequency and severity in adults 18years +. We will also examine the psychosocial, neurocognitive, neurobiological, neuroimaging and physiological effects of reconsolidation blockade treatment in adult participants with PTSD. Our research questions include: 1. Primary question: Will a 6-session reconsolidation blockade treatment be efficacious in reducing core PTSD symptoms frequency and severity? 2. Secondary question: Are there psycho-social, cognitive, and biological markers (genetic, circulating, and neural) that can predict treatment response to reconsolidation blockade treatment?

This is a study to determine if the FUNCAP 27 can be used as an instantaneous measure of perceived functional capacity in those with ME/CFS and Long Covid when at baseline and in a state of PEM(Post Exertional Malaise). We are doing this to establish a measure that can detect short term fluctuations in health that will be used in later interventional clinical trials. We aim to recruit 1000 participants for 2 questionnaires and 1 enrolment survey taking 6-20 minutes at enrolment (including reading the consent forms), 15-35 minutes when well and 10 -20 minutes in PEM. The questionnaire can be completed with the aid of a carer and paused for completion at a later time.

In the intensive care unit (ICU), non-invasive ventilation (NIV) is a treatment option for patients with respiratory failure. NIV involves the delivery of oxygenated air from a ventilator to the patient via a mask. The mask is secured to the patient’s head using straps that sit around the head to hold the mask over the nose and mouth. The purpose of NIV is to reduce the likelihood of invasive mechanical ventilation that requires the insertion of an artificial airway or breathing tube. Traditionally NIV masks cover the entire nose and mouth, resting on the nasal bridge. This can in rare instances lead to the development of pressure injuries on the bridge of the nose and as such facial disfiguration. At Sunshine hospital the Nivairo® mask is routinely used for NIV. This mask sits across the nasal bridge. In this study we would like to determine if the Visairo® mask that does not have a nasal bridge is equivalent to the Nivairo® mask for the delivery of NIV.