ANZCTR search results

The purpose of this study is to collect clinical data on Colorectal cancer patients with Stage II and Stage III disease and process this on the colorectal cancer data registry in order to generate a personalised care plan summary. Who is it for? You may be eligible for this study if you are a patient with Stage II or III colon cancer and fit for chemotherapy. You may also be eligible for this study if you are a GP monitoring patients with colorectal cancer fitting the inclusion criteria. Study details A personalised care plan summary will be provided during the second consultation visit with the oncologist and has the following components including cancer stage, planned treatment, planned follow-up visits and cancer helpline resources. This care plan summary will be created by your oncologist and will take an additional 10 minutes to generate the care plan from the database and then go through the information with you. You will be requested to complete a questionnaire after completion of your treatment. It is hoped that results generated from this study will help us determine if the provision of a personalised care plan can be extended to other tumour streams to help other patients.

The most common traumatic hand injury we see at CHW in hand therapy is a fracture of the proximal phalanx bone of the finger and thumb. Current practice involves 5 weeks of thermoplastic splinting with a minimum of 3 face to face outpatient appointments. We would like to investigate the effect of reducing splinting time for children aged 5-16 years, who present as clinically healed at 3 weeks post proximal phalanx fracture. This study aims to determine whether we can reduce overall treatment time for children who have sustained a proximal phalanx fracture. Participants will be recruited at their 3 week follow-up appointment. All participants will be assessed by a senior hand therapist for fracture healing. Those that are clinically assessed as being healed at 3 weeks will be included in the trial. The first group will follow our current protocol and remain splinted part-time for a further 2 weeks. The second group will follow a new protocol and will cease splinting. All participants will be followed up at 5 weeks post injury, as is current practice. At 5 weeks, assessment will include grip strength, range of motion and a patient reported questionnaire. The only additional time commitment will be a follow up phone call at 8 weeks post injury which may take 5 minutes of the parent or guardians time to re administer the PRQ. Safety will be ensured through interventions being provided by a senior hand therapist, education, written handouts and regular follow-up.

The present study is a case series where individuals with a diagnosis of major depressive disorder will be offered 12 sessions of imagery rescripting. The first aim will be investigated using cross-sectional data collected at the baseline phase: to examine the prevalence, content, characteristics and responses to intrusive memories reported by participants. The second aim is to determine whether participants endorse features of maladaptive schema modes - as outlined in Young's (2006) Schema Mode Model. The final aim is to evaluate whether a 12-session imagery rescripting intervention is efficacious at reducing symptoms of major depressive disorder, as well as intrusive memories and rumination. Hypotheses: 1. Participants will report frequent and distressing intrusive memories about a range of negative autobiographical events. Intrusive memories will be associated with the severity and maintenance of depressive symptomology. 2. Intrusive memories that are experienced as predominantly sensory will be associated will greater distress than those experiences as predominantly verbal. 3. Rumination will be positively associated with intrusive memories. 4. Participants will report activation of maladaptive child, parent and coping schema modes. Schema mode activation will be associated with the severity and maintenance of depressive symptomology. 5. Following 12 sessions of imagery rescripting, participants will experience less frequent and distressing intrusive memories, as well as reduced rumination and depression symptomology.

Diabetes affects nearly one million Australians. In more than 80% of diabetics who develop foot ulcers, poor wound healing results in the need for lower limb amputation. There is currently no treatment available for wound healing. This study aims to identify whether there is an association between circulating HDL cholesterol levels and the rate of wound healing in diabetic and non-diabetic patients. Over the last five years it has become evident that the functionality of the HDL particle is more predictive of disease outcome than HDL cholesterol levels. We will therefore also test HDL functionality is a series of ex vivo assays established in our laboratory. This study seeks to understand the relationship between HDL and wound healing in diabetes.

The purpose of this study is to conduct three-dimensional total body photography to monitor skin lesions and improve the early detection of melanoma and other skin cancers. Who is it for? You may be eligible for this study if you are aged 18 or over and have a regular doctor. Note, that you do not need to have been diagnosed with skin cancer or be at risk of skin cancer to participate in this study. Study details All participants will have three-dimensional total body photography (excluding skin beneath underwear and scalp) to create a record of all pigmented and non-pigmented skin lesions. These scans will happen at various frequencies over the 3-year study period, depending on the participant’s melanoma risk group. The risk group is determined by completing a questionnaire to assess your risk of developing melanoma. As part of this study, all participants will complete yearly questionnaires about their sun behaviour, quality of life and skin cancer history. It is hoped this research will improve identification and tracking of skin lesions (including potential melanomas) and reduce appointment times and healthcare costs.

This feasibility study is a preliminary step in the planning of a multicenter randomized controlled trial (RCT), assessing the influence of placebo versus cefazolin on the incidence of neonatal and childhood atopic diseases. The primary outcome will be the incidence of infant allergic disease assessed using parental questionnaires based on modified Barwon Infant Study questionnaires. A composite outcome based on the presence of atopic dermatitis/eczema; the presence of food allergy and the presence of recurrent wheeze, in the first 12 months of life. A secondary aim is to demonstrate feasibility as well as acceptability of the concept to patients and clinicians. We will also collect a range of biological samples (maternal and neonatal) for preliminary microbiological and immunological analysis, to assess the impact of pre-delivery cefazolin. This will guide targeted biological sample collection in the subsequent RCT.

In the Northern Territory, nine-months of daily isoniazid is currently recommended for the treatment of Latent Tuberculosis Infection (LTBI), but less than 50% of those offered treatment complete it. A three-month LTBI treatment regimen consisting of 12 weekly doses of two drugs (isoniazid (H) & rifapentine (P), known as ‘3HP’) is safe and effective. This regimen shows promise for improving completion of LTBI treatment but is yet to be taken up in Australia. Darwin TB Clinic will implement 3HP for treatment of LTBI among patients in the greater Darwin area. We will evaluate the implementation of 3HP by measuring treatment completion, adverse events, cost-effectiveness, and patient and provider acceptance.

This study aims to integrate early palliative care known as Care Plus in routine practice for patients with advanced cancers. Who is it for? Adults with a targeted advanced cancer who present to one of the study's hospital sites (St Vincent's Hospital Melbourne, Peter MacCallum Cancer Centre and Lyell McEwin Hospital), and who have reached a certain point in their illness will receive Care Plus as part of the hospital's new practice change. Study Details Six months prior to introducing Care Plus at each hospital site, patients with targeted advanced cancers who reach a key point in their illness will receive usual oncological care (Control group). This involves the treating clinician making referral to palliative care at their discretion. During the practice change period, in which Care Plus is introduced, all patients with targeted advanced cancers reaching a key point in their illness will, by default, receive usual oncological care by their treating clinician AND Care Plus as part of the hospital's new practice change. This involves a scheduled palliative care consultation and ongoing follow-up visits with specialists and nurse specialists. During these consultations, patients and their caregivers will have the opportunity to discuss pain and nausea management, and any other physiological, psychological, practical, social and spiritual needs. It is hoped this research will contribute to reduced hospitalisations for cancer patients, improved quality of life and improved efficiency for the healthcare system.

Spinal cord injury (SCI) is a life-changing severe injury resulting in substantial physical/psychological impairment. While significant research has investigated adjustment following SCI, very little is known about how co-morbid cognitive impairment impacts adjustment. It is believed around 50% of people with an SCI may have significant levels of cognitive impairment. Therefore, the major objective of this proposal is to (1) provide conclusive information about the extent and causes of cognitive impairment in adults with SCI; (2) to improve the clinical skills of rehabilitation teams to detect and manage cognitive impairment during the rehabilitation phase by developing multidisciplinary guidelines and strategies for use in the SCI rehabilitation phase, targeted at those with cognitive impairment.

The aim of the study is to explore the efficacy of the 4-week online Coeliac.Mindovergut.com resilience program for individuals living with coeliac disease and low to moderate psychological distress. The Coeliac.mindovergut.com resilience program is based on 5 modules (1 module per week), with the 5th module being optional. Each module (consisting of videos, text, handouts, and audio files e.g. relaxation tracks) is designed to be completed once a week, taking approximately 30 minutes, with associated homework-based activities taking a further 20-40 minutes per day. It is hypothesised that participants will report reduced psychological distress and increased quality of life.