ANZCTR search results

We are recruiting healthcare professionals aged over 18 years old to participate in a 1-year internet based study, called the Actionable Intime Insights (AI2) Study . The study aims to explore whether the use of patients Medicare Benefit Scheme (MBS) and Pharmaceutical Benefit Scheme (PBS) claims data held in My Health Record, can unveil more sufficient ways for clinicians and other healthcare professionals to provide optimal health care to patients with a chronic mental illness. Specifically, when people go to visit their doctors, they typically lodge a MBS or PBS claim to subsidise some of the payment costs. However, to date, there has not been a successful way of monitoring and managing the MBS and PBS data. We hope that we can be the first to provide a long-term sustainable solution to this problem, with the implementation of our novel digital application called the Actionable Intime Insights (AI2) application. We believe the AI2 application will help transform the way clinicians and patients interact with each other and ultimately improve patient’s well-being and outcomes.

Media Smart (MS) is an 8-lesson school-based program that was developed by Dr Wilksch and Prof Wade and has been evaluated in a systematic program of research with over 2,000 participants. MS is now considered the leading ED risk reduction program worldwide for school-based, universal settings (i.e., given to all students regardless of risk status rather than selecting those at high-risk of an ED). However, many schools find 8 lessons difficult to timetable within the busy school program and given competing demands. Therefore the overall aim is to conduct an RCT to assess the efficacy of MS when it is delivered in shortened formats, namely a 2- and 4-lesson version, compared to the full 8-lesson program. The study design will include school class randomisation to: MS–2 lessons (MS-2); MS–4 lessons (MS-4); the full 8-lesson MS program (MS-8) and control group (normal school lessons with provision of a 1-page tip sheet on improving body image). Consistent with previous RCTs, MS will be delivered by trainee psychologists who will receive 5-hours of training in the program. Students will complete measures at baseline, post-program, 6- and 12-month follow-up. Measures will assess disordered eating and ED risk factors. This research is important in assisting with dissemination of the program given greater uptake is likely with a shorter curriculum. The rationale is not to replace MS-8 but to provide schools with informed, evidence-based alternatives for shorter versions that can better fit into the school program.

This project will be the first to test the effectiveness of the sleep wearable device called THIM for administering Intensive Sleep Retraining in the home environment. We will also examine the ability of THIM to provide effective and affordable treatment for insomnia, improve individual sleep health and general well-being. We predict that THIM-administered Intensive Sleep Retraining intervention condition will demonstrate: • increased total sleep time and sleep efficiency; • reduced sleep onset latency and time awake after sleep onset; • improvements in daytime functioning measures Compared to the Sleep Hygiene Control condition at post-treatment and two-month follow up time points.

Orthokeratology (OK) lenses are rigid contact lenses that are designed to be worn during sleep. Their purpose is to reshape the front surface of the eye (cornea) in order to temporarily correct short- sightedness, also known as myopia. Although their primary aim is to correct myopia and provide clear unaided vision during the day, studies have shown that they also have an effect on slowing or stopping the progression of short-sightedness in children, termed myopia control. Currently, research is underway to understand centration of OK lenses and the optical effects as a result of centration which may promote myopia control. Although optometrists will typically assess the centration of the lens in the open eye, it is not clear how much this influences treatment zone centration after overnight wear in the closed eye, and this warrants investigation. The aim of this project is to compare open eye lens centration with treatment zone centration after 3 nights of overnight wear of OK lenses. We will investigate open eye lens centration with and without eyelid interactions, as well as lens centration immediately after eye opening following short-term eye closure. Our intent is to determine how these measurements can be used clinically to predict treatment zone centration after overnight OK lens wear.

This study will look at different methods for administering anaesthesia for total knee replacements. The technical options we use nowadays are mostly spinal anaesthesia and general anaesthesia. In the past, spinal anaesthesia was the preferred option amongst anaesthetists. Today, the evidence shows that both techniques are similar in terms of complications. However, we still don't know which technique provides better pain relief. In this study, we will look into the pain levels of fifty patients who are having knee replacement surgery by checking the amount of morphine they have used during the research. Patients will be divided in 2 groups, general anaesthesia group and the spinal anaesthesia group. Patients won't be able to choose the group they are participating since this process will be done by an online tool. We hypothesise that the pain will be similar in both groups independent of the anaesthetic technique used. We will also look for patient satisfaction regarding the type of anaesthesia, nausea and vomiting and the anaesthesia efficiency. Results will help both patients and anaesthetists to have more information and more freedom to choose their preferred technique for this procedure.

The Best Start Trial aims to determine whether targeted physiotherapy interventions initiated up to 4-5 months earlier than typically commenced (3 months corrected age), will improve motor outcomes at the 16 week time point in infants at risk of cerebral palsy or motor delay. Parents or caregivers will be closely coached by physiotherapists in the provision of targeted motor interventions to their infant, commencing as early as 34 weeks gestational age until their infant is 16 weeks old. The motor outcomes of infants receiving the parent administered physiotherapy or motor therapy will be compared to current "usual care" to determine if either of these approaches is more beneficial than the other. It is hypothesised that the parent-administered approach will be more beneficial than "usual care" because of it's targeted physiotherapy content and improved continuity of physiotherapy delivery from the NICU to home.

The main purpose of this study is to assess if there is an association between cardiorespiratory fitness and acute aerobic exercise on tumour blood flow in patients with cancer that has spread to the liver. A secondary aim of the study is to determine the most effective exercise intensity for increasing tumour blood flow. Who is it for? You may be eligible for this study if you are aged over 18 and diagnosed with stage IV cancer with a liver metastases. Study details All participants in this study will be required to attend a single visit. Participants will perform an aerobic fitness test (YMCA). After a rest period, participants will ride on an exercise bike for 5 minutes, or take part in the sub-study which participants will complete 3 cycling tasks of varying difficulty. Each will last for 5 minutes and there will be a rest period in between each one. Physiological measurements will be taken before, during and after the intervention, including blood pressure, heart rate and oxygen saturation, as well as oxygen consumption and ultrasound measures. The study will extend the work of a current pilot study, investigating the safety and feasibility of intra-infusion aerobic exercise and help progress towards clinical application. The results will not provide a full picture into the mechanism or relationship of tumour blood flow and chemotherapy delivery but rather provide a platform for further research.

Acetate is a type of short-chain fatty acid that is normally present in the blood. In animal studies, increasing the level of acetate in the blood is associated with reduction of inflammatory processes in the body. The purpose this research project is twofold. 1. We wish to investigate how to increase acetate levels in the blood by comparing diets that have different levels of fibre. Fibre taken in the diet as dietary fibre is converted to small metabolites that include acetate by bacteria found in the lower part of the gut (colon) and this acetate finds its way into the blood stream. 2. We wish to determine if increasing the acetate levels in the blood does change immune cells and key enzyme activities in the blood that may reduce inflammation, just as it does in experimental animals. This study will help us to understand if dietary fibre can be used to reduce inflammation in conditions such as asthma or allergy in the future. In order to investigate this, we are asking for healthy volunteers to participate in a dietary intervention study that will involve consuming a diet with varying fibre level and having blood taken at the end of each diet (Morning of Day 5).. This research has been initiated by Dr. Jane Muir, a dietitian and Head of Translational Research at the Department of Gastroenterology. The results of this project will be used by Mr. Paul Gill as part of his Bachelor of Biomedical science honours degree.

The primary purpose of this trial is to evaluate the efficacy, safety and feasibility of alternating lorlatinib and crizotinib for the treatment of ALK-rearranged advanced non-small cell lung cancer. Who is it for? You may be eligible to enrol in this trial if you are aged 18 or over and have been diagnosed with ALK-rearranged advanced non-small cell lung cancer, refractory to prior therapy(ies). Study details All participants enrolled in this trial will begin with Induction therapy which involves taking lorlatinib tablets every day for 12 weeks. Participants will then move onto the Alternating phase. During the Alternating phase participants will take crizotinib for 4 weeks, then lorlatinib for 8 weeks, then crizotinib for another 4 weeks, and lorlatinib for 8 weeks until disease progression or unacceptable side effects. Following progression, some participants may be eligible to continue with alternating treatment or switch to continuous lorlatinib treatment until further progression, depending on whether your doctor believes that this would be of benefit to you. All patients will be reviewed up to every four weeks clinically, with bloods tests, CT scan and MRI (brain) and side effect assessments. It is hoped that the findings from this trial will provide information on whether alternating treatment with crizotinib and lorlatinib is feasible, safe and effective for the treatment of ALK-rearranged advanced non-small cell lung cancer with the potential to delay the emergence of drug resistance as compared to continuous lorlatinib therapy alone.

The primary purpose of this study is to use a scientific framework for evaluating whether an ancient Traditional Chinese medicine oil with a long history of use for muscle pain is effective in well-trained Australian males. Cheong Kun Oil is a topical preparation which has been marketed in Macau since the 1960’s for its beneficial effects on muscle pain due to exercise, strains and injuries. This study will scientifically investigate the efficacy of Cheong Kun Oil for reducing DOMS in the thigh muscles after eccentric exercise (exercise where the muscle is lengthened) in healthy, young, well trained males. The traditional Chinese medicine (TCM) Cheong Kun Oil is a topical preparation marketed in Macau since 1960’s and is popular for its beneficial effects on muscle pain due to exercise, strains and injuries. According to Chinese Medicine theory, the constituent herbs in the preparation help promote circulation, reduce inflammation and alleviate pain. Despite the long history of use, to date, clinical studies evaluating the efficacy of Cheong Kun oil in the management of DOMS have not been conducted. Therefore, the objective of this study is to evaluate the efficacy of Cheong Kun oil as a topical treatment for the management of DOMS and associated muscle performance in young healthy well-trained males.