ANZCTR search results

Lung cancer is the leading cause of cancer-related mortality and morbidity in Australia, with more than 8000 Australians predicted to die in 2018 alone. Due to the poor outcomes experiences by many lung cancer patients, clinicians attempt to provide rapid review, diagnosis and treatment and adhere to the timeframes suggested in the Cancer Council’s Optimal Care Pathway. Whilst scientific end points, such as survival are important, patient reported outcomes, such as quality of life and satisfaction with care are also vital. This move towards more patient-centric care is being championed in Western Australia by the Continuous Improvement in Care – Cancer (CIC-Cancer) Project. Are you eligible to take part in this study? This study aims to establish if providing guideline-driven care, in terms of timeliness, improves patient satisfaction amongst people with lung cancer. You may be eligible to take part if you have primary lung cancer and are undergoing treatment and have consented to have your clinical information collected by the CIC-Cancer database. What does the study involve? Patients will be asked to complete an 18 question survey at the time that they start treatment for lung cancer. The survey will assess different areas of patient satisfaction with care, including access to appointments and communication with their doctor. Patients will not be obliged to any other follow up. How will involvement in this study help patients with lung cancer? This study will help us to validate the Cancer Council Optimal Care Pathway and ensure that striving to achieve rapid review and treatment really is making patients more satisfied with their care.

The purpose of this study was to determine the costs associated with post-operative complications of those undergoing a colonic resection. Who is it for? Eligible patients included adult patients who underwent a colonic resection at the Austin Hospital between January 2013 and June 2018. All data was retrospectively collected. Study details Data was collected on any complication experienced by patients who underwent a colonic resection at the Austin Hospital between January 2013 and June 2018. It is hoped that this study will: 1) Quantify the costs implicated by postoperative complications following colonic resections including pharmacological costs, medical costs, operative costs, intensive care unit costs and ward costs. 2) Quantify the impact of postoperative complications on costs within the following patient cohorts: a. Emergency and elective procedures b. Laparoscopic, open and combined procedures c. Malignant and non-malignant diagnoses 3) Identify key patient and perioperative variables associated with increased costs and adverse patient outcomes to ascertain areas for improvement allowing the development of evidence-based guidelines with the ultimate goal of improving patient outcomes and efficiency of our health services.

In this study we aim to see if biofilms (groups of bacteria) are present in HS lesions, and see what bacteria are present, how they are grouped and what effect they have on the skin and how this relates to disease severity.

Working memory (WM) training using emotional stimuli has been designed to improve the mental control of emotional information. The aim of this project is to test whether individuals with elevated social anxiety would benefit from WM training with emotional stimuli. The project aims to build on a previous project (ACTRN12618001196235) and further explore the effects of WM training with emotional stimuli. It is anticipated that individuals with elevated social anxiety who engage in a WM training task with emotional stimuli, relative to those who engage in a control training task, will exhibit the following after training: (a) reduced social-evaluative self-beliefs, (b) increased self-esteem, (c) improved cognitive flexibility, (d) improved adaptive thought generation, and (e) decreased anxiety.

The human microbiome, the population of microbes occupying various body sites, is already known to have a major impact on human health with the changes in the gut microbiota during pregnancy known to be particularly fascinating. However, there is limited research on the microbiome and its relationship to maternal and newborn health and disease. Therefore, the aim of this study is to recruit a large perinatal and newborn cohort, of approximately 2000 participants, in order to comprehensively investigate the microbiome during this critical period of a mother and child’s life. Women will be recruited prior to conceiving a child, to fully examine the microbiota, and observe the changes from pre-conception, conception, and pregnancy through to birth and into the first year of thechild's life. There is a projected time commitment for participants of 22-33months, depending on time of conception.

The purpose of this study is to assess the utilisation of an Implantable Loop Recorder to aid in the management of symptom control of Paroxysmal Atrial Fibrillation.We hypothesise that an Implantable Loop Recorder can be effectively used in a nurse led cardiologist supported AF clinic to guide and co-ordinate the management of patients with a high burden of symptoms related to their Atrial Fibrillation.

Peripheral IV cannulation is one of the most frequently performed invasive procedures in the hospital setting, and an essential means of providing hydration, nutrition and medication to admitted patients, including neonates . The insertion, monitoring and maintenance of these devices, to prevent complications, are an important component of neonatal nursing care. The most common complications of PIVC use include extravasation, infiltration, occlusion, infection, and phlebitis - accounting for the failure and removal of 95% of PIVCs. Although these complications are usually minor, some neonates may experience serious, or even life-threatening sequelae, with the potential for long-term functional difficulties, significant scarring, and psychological effects. The current failure rate of PIVC in the neonatal population is estimated at around 60%, however the optimal securement method of a PIVC has not been well established. We have designed a randomised controlled trial to assess whether using a specifically designed splint and protection device may be useful to prevent PIVC failure as compared to standard splinting and securement in the neonatal population. Our hypothesis is that the specifically designed splint and protection device will significantly decrease PIVC failure as compared to standard splinting and securement in the neonatal population.

This study is a pilot study looking at the efficacy and feasibility of pre-operative very low energy diet in patients with BMI greater than 30, prior to laparoscopic colorectal study. Participants will be prescribed the Optifast Intensive Program on a daily basis after enrolment in the study and will take the Optifast meal replacement until the day of surgery.

The aim of Supernova 2 is to investigate the effects of 3 weeks adaptation to the LCHF diet and 2 weeks of deadaptation (reintroduction of high CHO diet), on substrate use and subsequent race performance as well as several health related outcomes such as inflammation, iron health, bone health and gut function in world class female and male race walkers.

This study will be conducted to determine if smart phone-based (Kardiamobile) single lead electrographic (sECG) recording systems have a superior yield for the diagnosis of hearth rhythm disorders compared to repeating traditional ambulatory monitoring (Holter) in patients with undiagnosed palpitations. Participants who meet the inclusion criteria will be randomised 1:1 to either the intervention group (Kardiamobile sECG) or control group (standard care with multiple ambulatory Holter monitors). This clinical trial will run over 2 years with a planned recruitment of 80 patients (40 in each group). A follow up period of 6 months will aid to determine which approach is superior for the diagnosis of symptom related-heart rhythm abnormalities. Control arm Patients randomised to the control arm will be managed as per standard care. Standard care will comprise of sequential ambulatory multi-day Holter monitors (5 days), up to 3 in number, over a period of 6 months, separated by at least 4 weeks. Intervention arm Patients randomised to the intervention arm will be offered the Alivecor KARDIAMOBILE (Smart phone-based sECG). The smartphone/smartwatch platform allows a single lead ECG recording of up to 5 minutes. Study outcomes The primary outcome of this study will be the proportion of patients in whom a definite diagnosis of palpitations is made with an underlying rhythm that correlated with symptoms (symptom-rhythm correlation) or a serious rhythm abnormality is recorded over the 6 month follow up period.