ANZCTR search results

This is a safety study of quadrivalent inactivated influenza virus vaccine, Afluria Quad and Afluria Quad Junior, conducted over three Southern Hemisphere vaccination seasons to provide ongoing characterisation of the reactogenicity profile of Afluria Quad in the clinical and public health environment.

Exendin PET scans are special nuclear medicine imaging scans. These scans can detect cancers whose cells have a chemical, called the GLP1 receptor, on their surfaces. However, we are unaware of any reports of the use of Exendin PET scanning in prostate cancer. The purpose of this study is to determine if prostate cancer can be detected by Exendin PET scans. Who is it for? You may only be eligible for this study if you have metastatic castrate-resistant prostate cancer and have already been identified as potentially suitable for the study by our research team. Study details The study will assess whether PET scans using the chemical called Exendin can detect metastatic prostate cancer. Participants will have had a PET scan using the chemical PSMA (which is the usual type of PET scan used to detect prostate cancer) within the preceding 2 weeks. They will then have a single Exendin PET/CT scan at a major hospital. The procedure will involve: a) Injecting the study chemical (called [68Ga]-DOTA-Exendin) into an arm vein. b) Finger prick glucose testing to confirm participant blood sugar levels. c) An Exendin PET scan 60 minutes after the chemical injection. We hope this will demonstrate that prostate cancers can be detected by Exendin PET scans. If we can demonstrate that, we will have confirmed that prostate cancers bear GLP1 receptor.

This study will examine the effects of biomechanical tape on pain and function in people with tennis elbow. Each participant will attend three sessions, where one of the following will be applied in a random order, 1) biomechanical tape, 2) control tape, and 3) no tape. Participants will have their pain intensity, grip strength, muscle activity, and wrist posture measured three times during each of the three sessions, 1) before the tape (or no tape), 2) immediately after the tape (or no tape), and 3) immediately after an exercise circuit wearing the tape (or no tape). The research hypotheses are that biomechanical tape will result in a reduction in pain, a reduction in wrist extensor muscle activity, an increase in pain-free grip strength in the affected arm, and an improvement in wrist posture, when compared to the control tape technique, or no tape.

Effect of eating at night time results in blood glucose levels up to 6 times higher than the same meal consumed in the morning. Dietary polyphenols favourably influence blood glucose, but studies are usually undertaken in the morning. We hypothesise that polyphenols from green tea incorporated into a meal may be effective at lowering blood glucose both in the morning and at night.

In patients who have both liver and kidney failure, average circuit life of continuous renal replacement therapy (CRRT) is approximately half compared to other group of patients receiving CRRT due to circuit clotting. However, liver failure patients can’t receive anticoagulants to prevent circuit clotting because of high risk for developed toxicity and bleeding. Modified membrane (oXiris®) is coated with anti-clotting material and has ability to remove cytokine in blood. This study is a pilot, single-center, prospective, randomized, crossover, open-label, clinical controlled trial which aim to assess the efficacy of modified membrane (oXiris®) compared to standard membrane and we hypothesized that modified membrane (oXiris®) has ability to prolong CRRT circuit life compared to standard membrane dialyser and decrease the blood level of cytokines.

This study will investigate the effects of cheese consumption on metabolic and gut health in healthy human subjects. Individuals participating in this study will be required to follow their usual diet (habitual diet) with minor adjustments regarding the consumption of cheese and dairy fermented products. Investigating the effects of cheese in the habitual diet under free living conditions will generate clinically relevant results and knowledge. The primary aim of this project is to characterise the response of the saliva, urine and stool microbiome and metabolome to habitual diets that differ in their type of production (quality)

This is a randomised controlled trial comparing negative pressure wound therapy (Prevena) with standard dressings for emergency laparotomy. The objective of the trial is to determine whether a negative pressure dressing reduces rates of surgical site infection and wound-related morbidity. This is a single-site study which aims to recruit 200 participants.

Diagnostic lung ultrasound will be used to diagnose acute lobar atelectasis in a mechanically ventilated population in intensive care. Lung ultrasound scans will also allow the research physiotherapist to assign aeration scores pre and post delivery of chest physiotherapy treatment. We hypothesise that lung ultrasound will be able to detect changes in lung aeration associated with a single chest physiotherapy treatment. This single centre prospective cohort trial of 43 mechanically ventilated patients will be conducted in intensive care at Royal North Shore Hospital.

Instability of the knee cap is a common problem and has a high recurrence rate, even with appropriate physiotherapy. When it has recurred, surgery becomes the necessary treatment. The surgical technique most commonly used involves the use of one of the patient's hamstrings to make a new ligament, the medial patello-femoral ligament. This technique uses one of the patient's own hamstrings and there is increased pain and an increased risk of complications associated with taking the hamstring graft. An artificial ligament, referred to as the ligament augmentation reconstruction system (LARS), is an alternative ligament that has been used for this operation, instead of the hamstring graft. This has the potential benefit of less pain, and a lower risk of complications. However there is no research to compare the outcomes of the two techniques used to reconstruct the ligament. The goal of the study was to compare the patient outcomes in patients undergoing the operation with the use of a hamstring graft versus the use of the LARS graft. Patients who are appropriate candidates and who agree to take part in the study, are randomly allocated to group 1 who have a hamstring graft, or group 2 who have a LARS ligament. Both groups will follow the same rehabilitation protocol to be supervised by a physiotherapist. Patients are allowed to weight bear as tolerable with a brace on, and the range of motion permitted in the brace is gradually increased over a period of 8 weeks. After this the patient can wean from the use of the brace. Patients can expect to make a complete recovery within 4 months of the surgery. The outcomes of interest are a questionnaire referred to as the Kajula score and Tegner activity score. These are completed before surgery and again at 1, 2, and 5 years post surgery. The results will be compared using statistical analysis.

The purpose of this study is to quantitatively compare early outcomes following duct to duct anastomosis during whole liver transplantation with or without a biliary stent. Randomised comparative data showing non-inferiority in the stent-free group could result in fewer post-operative biliary/endoscopic interventions, and change our current, non-standardised practice. Biliary stent placement during duct to duct anastomosis in whole liver transplantation confers no benefit with respect to biliary anastomotic complications when compared to a stent-free anastomosis but does result in a greater number of post-operative interventions to remove retained stents.