ANZCTR search results

This study aims to evaluate whether stereotactic ablative radiotherapy (SABR) is a reasonable and safe treatment option for patients with non-small cell lung cancer (NSCLC) where their cancer is large and/or has also spread to the nearby lymph nodes. Who is it for? You may be eligible to join this study if you are aged 18 or older with a diagnosis of stage III or IV non-small cell lung carcinoma and ineligible for standard of care concurrent chemo-radiotherapy. Study details Participants in this study will undergo stereotactic ablative radiotherapy (SABR). SABR is a specialised form of radiotherapy whereby large doses of radiation are given in fewer treatments. Participants will attend between 6-12 SABR sessions across 2-3 weeks, and will then be followed up regularly post radiotherapy, in order to evaluate treatment safety, quality of life, tumour response and survival. It is hoped this research will contribute to the field of oncology and improve the health outcomes of patients with lung cancer.

This study will determine if the use of adavosertib (cohort 1 & 2) or ceralasertib (cohort 3) as monotherapy provides clinical benefit to patients with high grade serous ovarian cancer Who is it for? You may be eligible to join this study if you are aged 18 and above and have platinum resistant high grade serous ovarian cancer with Cyclin E1 over-expression Study details Participants in this study are now being enrolled into an additional third cohort. Cohort 1 and 2 enrolled 71 participants with Cyclin E1 over-expression (Non-amplified or Amplified). who received the same intervention: daily oral adavosertib tablet from Day 1-5 and Day 8-12 of a 21-day cycle for a maximum of 24 months. Cohort 3 plans to enrol 32 participants with Cyclin E1 over-expression (Non-amplified or Amplified). Participants will receive twice daily oral ceralasertib tablets from day 1-14 of a 28 day cycle for a maximum of 24 months. Patients will undergo 4-weekly appointments for their treatment duration, have bloods taken for translational research and may also be required to have a biopsy performed after the end of their first cycle. All participants will be monitored regularly in order to assess clinical response and treatment safety. It is hoped that IGNITE will provide clinical benefit to patients with high grade serous ovarian cancer who have Cyclin E1 expression and will be able to provide a new treatment option for patients with this genetic fault.

The transition from the supported environment of tertiary medical school into the workforce poses a potentially stressful period for a new doctor. Compounding this, many graduates describe feeling under supported within this new role. This pilot project will see initiation of the “Resident Ready Network” (RRN), a near-peer mentoring program, linking graduating students with junior doctors in the hospital system in Brisbane. We hope that the RRN can be the catalyst for lasting relationships and yield benefits to those who engage by helping to develop an awareness of work life balance as well as support mechanisms available to new doctors. The researchers hypothesize that this program will be acceptable and helpful to these transitioning students and that supporting them in this fashion may even have flow on effects in decreasing their stress levels. We will be analysing stress levels as well as user satisfaction at varying time points throughout the study and engaging with users at it’s 12 month conclusion to ensure the program is built for purpose.

This study aims to compare the effect on falls and other measures of health and wellbeing of: a) a group-based yoga exercise program over 12 months, and b) a seated unsupervised yoga relaxation program over 12 months. Participants allocated to the group-based yoga exercise program will attend either face-to-face yoga classes at established yoga studios with experienced yoga teachers or online classes delivered via Zoom for one hour, twice weekly for 40 weeks. Participants allocated to the yoga relaxation program group will attend two either face-to-face or online one-hour workshops to learn a relaxation yoga program. We hypothesise that greater effects on the rate of falls will be evident from the group-based yoga exercise program compared to the yoga relaxation program.

Bionomics Limited is developing BNC210 for the treatment of anxiety, and trauma- and stressor-related, disorders including Post-Traumatic Stress Disorder (PTSD). This single-centre study, will evaluate the pharmacokinetic profile, as well as the safety and tolerability, of single ascending doses of BNC210 in five healthy male volunteers. Participants will receive single doses of 600 mg, 900 mg and 1200 mg BNC210 as a tablet formulation, during three separate dose periods. There will be a minimum 5 day washout period between each dose period.

The aim of this study is to develop an acceptable, useful, and practical training program, BipolarWISE, to assist adults with bipolar disorder to manage their condition and enhance their quality of life. BipolarWISE is an online group and individual intervention with an optional website component for adult family members/friends who support a person with bipolar disorder and would like to better understand and deal with the disorder and maintain their own wellbeing. The feedback from participants will assist in refining the final program which we aim to test in a large trial. If it is effective, the program can be disseminated to those affected by bipolar disorder.

The drawbacks of current therapies and the lack of an approved as needed (PRN) treatment for Pulmonary Arterial Hypertension (PAH) that improves exercise ability and quality of life, form the basis for development of RT234 (inhaled vardenafil). The current study will identify the effective dose(s) of RT234 to acutely improve pulmonary vascular haemodynamics when delivered in a dose escalation manner in subjects with World Health Organisation (WHO) Group 1 PAH undergoing right heart catheterisation (RHC). In addition, this study will also provide valuable efficacy and safety insights into the interactions between RT234 and background disease-specific PAH therapy on pulmonary haemodynamics and right heart function.

Hardstyle kettlebell training has emerged in recent years as a novel training method which claims to improve all measures of health-related physical fitness. It is proposed that kettlebell training might serve as an ideal cost-effective prophylactic to promote healthy ageing in sedentary adults. This project seeks to establish the efficacy of a pragmatic hardstyle kettlebell training program on measures of grip strength, health-related physical fitness and mental health in sedentary older adults. It is hypothesised that clinically meaningful changes in health-related physical fitness and mental health will be observed. Results will help inform further investigation comparing the effectiveness of hardstyle kettlebell training with other community-based group exercise programs for older adults.

This randomised trial will evaluate the effectiveness of two different sit-stand recommendations on changes in pain in office workers with lower back pain (LBP). Who is it for? The study is for office workers aged over 18 years, who have a sit-stand desk or workstation and have LBP. Workers with medical conditions that limit standing will be ineligible. Study details Participants will be randomly assigned to one of two intervention groups (Recommendation A or B) for 3 months. Participants in group recommendation A will be prescribed a fixed recommendation of alternating sitting and standing at a 2:1 ratio of 30 minutes sitting followed by 15 minutes of standing by a health professional. Participants in group recommendation B will be prescribed a more flexible recommendation which involves developing a sitting and standing ratio for that person. Participants will be assessed on immediate (at 2 weeks) and short-term (3 months) effects on their LBP and sitting and standing patterns. Acceptability and feasibility of the intervention, pain-related disability, and a range of work-related measures (e.g. productivity) will be assessed after 3 months. If either recommendation is found to be effective, acceptable, and feasible, it could be readily incorporated into protocols for ergonomists and workplaces to use when installing sit-stand desks.

We hypothesise that introducing a well-designed mindfulness app will reduce staff stress. A multi-site, two-arm randomised controlled trial (RCT) will be conducted at two Queensland hospital EDs. Participants will be encouraged to practice daily, 10 minutes of app (Headspace app®) guided mindfulness-meditation during the four weeks intervention period. The simple intervention has the potential to reduce hospital ED staff stress and improve staff wellbeing. Ultimately it could also improve the bottom-line of operating budgets in Queensland hospitals and most importantly, improve patient care.