ANZCTR search results

This is a pilot dietary intervention study involving an 8-week dietary intervention prescribed in addition to standard therapy for patients with mild-moderately active ulcerative colitis. People who meet the inclusion criteria and who provide informed consent will be provided with a Dietitian administered meal plan for the study period. Tolerance of and adherence to the prescribed diet will be assessed, along with the nutritional adequacy of the diet. The impact of the diet on luminal intestinal inflammation will be assessed, as well as its effect on the gut microbiome.

The predictable management of recession in the lower anterior teeth is very important to avoid tooth loss. The conventional gum graft alone and "cow bone" alone may not be stable enough to treat the gum recession and peri-implantitis. This study will look if the addition of emdogain will improve the result of conventional gum graft and bone graft on teeth and implants.

In recent years, presentations to alcohol and other drug (AOD) treatment services by clients seeking treatment for problems with methamphetamine have increased dramatically in Australia. Withdrawal management (i.e. inpatient “detoxification”) is one of the most common treatments for people with severe methamphetamine use disorder (MUD). However, less than 20% of people who undergo withdrawal management remain abstinent from methamphetamine 3 months later. This highlights the need for brief, adjunctive treatments that can be delivered during inpatient withdrawal to help prevent relapse. “Approach bias modification” (ABM), a brief computerised cognitive training program designed to reduce impulsive tendencies to approach drug-related stimuli, has been shown to be effective for alcohol use disorders, but has not yet been trialed for methamphetamine. ABM involves repeated trials where patients respond to drug-related and neutral/healthy stimuli (e.g. pictures of alcoholic and non-alcoholic drinks, in the case of alcohol ABM) by “avoiding” drug-related stimuli and “approaching” other stimuli. Before executing costly randomised controlled trials applying ABM for MUD, it is important to establish whether it is acceptable (e.g., whether exposure to images of methamphetamine during ABM is well-tolerated or whether they are excessively triggering/distressing) and whether it is feasible in relevant treatment-settings, including inpatient withdrawal. The aim of the present study was to examine the feasibility and acceptability of ABM during inpatient withdrawal from methamphetamine. We predicted high rates of uptake and completion of training (demonstrating feasibility); and low rates of withdrawal, minimal triggering of cravings, and high ratings of the tasks’ acceptability from participants (demonstrating acceptability). Although this was a small, uncontrolled, open-label pilot study, we also examined rates of abstinence from methamphetamine at 2-week and 3-month follow-ups, expecting that it would compare favourably with those reported in multi-site treatment outcome studies of MUD patients undergoing inpatient withdrawal.

The aim of this research is to develop a mobile based multidisciplinary virtual clinic based on the existing platform (MoTER) and to investigate the impact of such a clinic on health outcomes and clinical management of patients with Acute Coronary Syndrome (ACS). The primary hypothesis is that participants in the MoTER-ACS arm will have satisfying uptake and adherence to the intervention. Patients in the MoTER-ACS arm will have access to the mobile based intervention program which consists of educational materials, self-management interventions and healthcare providers' feedback for the period of three months.

Computer vision syndrome is defined as a group of eye and vision related problems that result from prolonged computer, tablet, e-reader or cell phone use. Its prevalence ranges from 75% to 90% among computer users. The most common ocular symptoms associated with computer vision syndrome are visual fatigue, followed by blurred vision, and dry eyes; these symptoms occur immediately, or after several hours of computer use. Recently, spectacle lenses have been introduced into the clinical practice with an aim to alleviate symptoms of computer vision syndrome. However, there are currently no high quality clinical trials that have investigated the efficacy of these lenses for the treatment of computer vision syndrome. Hence, this project comprises of series of experiments to scientifically investigate whether these spectacle interventions affect signs and symptoms of computer vision syndrome.

A single blinded, randomised controlled trial in women who sustain second degree vaginal tears, to assess whether the use of either Ropivacaine or Lignocaine with Adrenaline infiltration prior to vaginal-perineal repair results in either reduced blood loss or reduced pain compared to standard treatment with lignocaine.

This research proposal will explore technologies to efficiently enhance clinical decision-making and provide interventions to the deteriorating heart failure patient at an earlier time point than standard care. It will determine if an alternate design of follow-up care utilising the “Personify Care” clinical platform can demonstrate efficiencies and in doing so decrease the substantial burden on this area of health service.

Sofosbuvir and Velpatasvir (SOF/VEL) are new antiviral drugs recently registered and listed in Australia for the treatment of hepatitis C (HCV). These medications are highly effective, orally administered, well tolerated and work against all the different genotypes of Hepatitis C. In preclinical evaluations in animals they have been shown to be safe during pregnancy. This study will evaluate the safety and pharmacokinetics of antenatal SOF/VEL treatment given for 12 weeks during the second and third trimester. If proven to be effective, antenatal treatment of HCV with SOF/VEL will prevent transmission of HCV to the baby, community transmission of HCV and maternal HCV-related liver disease . It will also reduce the maternal anxiety and stigma of potential transmission.

Australian data on pathogens causing acute cholangitis is lacking. Americian, European and Asian data state that E.Coli, Klebsiella species and Enterococcus species are the three most common pathogens causing acute cholangitis. This study aims to identify pathogens causing acute cholangitis from positive blood cultures in an Australian setting as a guide to antibiotics selection and to analyse their impact on in-hospital length of stay (LOS).

Dizziness when moving (vertigo) is a common symptom of dysfunction in the vestibular system of the inner ear. Problems with this inner ear system can result on poor balance and falls. Trained vestibular physiotherapists can identify and manage common causes of vertigo and balance dysfunction. However, people who have been admitted to hospital following an injurious fall may not be able to move quickly enough to provoke vertigo, and therefore may not be identified as needing physiotherapy vestibular assessment and management, The aim of this study is to determine whether the identification and management of vestibular dysfunction in patients admitted to sub-acute rehabilitation after a fall decreases the rate of falls in the first three months back home after discharge.