ANZCTR search results

The purpose of this project is to determine how effective behavioural change strategies are in managing fluid amongst people who are receiving haemodialysis treatment for their kidney disease. Fluid management is important during dialysis because having too much fluid can cause high blood pressure, swelling, breathing difficulties and high weight gain, which can then lead to increased hospitalisation and mortality. Behavioural change strategies have been successfully used in previous research for helping participants to manage other health related behaviours, such as reducing unhealthy snacking, however they have never been used to help manage fluids in patients on haemodialysis treatment. This project aims to address this gap in the research.

This study is intended to identify, adapt, evaluate, preliminary efficacy, and gather patient perspectives of 'off-the-shelf' virtual reality games for use in upper limb rehabilitation after stroke. It aims to find out whether readily available games for virtual reality can be used and modified to best supplement regular physiotherapy rehabilitation post stroke, to also increase therapy hours. The hypothesis is that adapted virtual reality games will be a useful therapeutic tool, and will result in some improvement in upper limb rehabilitation post stroke,.

Large ventral hernias are a source of significant morbidity and pose a considerable surgical challenge. A hernia is abdominal wall muscular defect, allowing protrusion of abdominal contents under the skin. Surgical repair brings the edges of the abdominal wall opening (muscle edges) together. BTA prevents the muscles from contracting (approx 3 months) and thus reduces the lateral pulling 'force' on the surgical repair of the hernia. The study aims to perform a double- blinded randomised placebo-controlled trial to evaluate the effectiveness of BTA as an adjunct to surgical hernia repair of large ventral hernias. Participants will be randomised into two groups: one group will receive BTA injections, the other normal saline injections, into abdominal musculature. All participants will then undergo a surgical hernia repair 4 to 6 weeks after the injections. 84 participants will be recruited to each group (total: 168 participants). Our hypothesis is that BTA can improve the success of hernia repair by better intra-operative closure, better post-operative recovery , reduced recurrence of a hernia and overall reduced health expenditure.

We wish to investigate whether vaccine intentions, attitudes, and knowledge are differentially influenced when presenting general versus specific long COVID and booster-related information. General information presents risk information in regard to long COVID as a whole, whereas the specific presentation shows information on specific long COVID symptom categories. We therefore aim to investigate whether there is a particular presentation of information that more effectively communicates long COVID and vaccine messages. We also wish to see if there are any effects of adding a cognitive load task that some participants will have to allocate their attention to. We predict that participants viewing the general long COVID information will show higher vaccine intention, positive attitudes, and knowledge regarding boosters; we also predict that participants under cognitive load will have less vaccine intention and knowledge, as well as more negative attitudes, compared to participants under no load. Finally, we predict that the benefits of general information on intention, attitudes, and knowledge will be even more pronounced for those under cognitive load.

The Canberra Family Study aims to explore 11 outcomes through use of validated questionnaires administered to new parents. The key questions in our 11 substudies are: 1) How do we enhance maternity models of care? 2) How do we increase healthcare advocacy? 3) What supplements do women take in pregnancy and why? 4) What will enhance the birth experience? 5) How to help IVF parents to parent? 6) How do we help parents of preterm babies to parent? 7) How do we help mothers’ confidence with parenting 8) How do we ensure there is optimal follow up of women who experienced a pregnancy complication? 9) Explore if there is a relationship between sleep and pregnancy outcomes, 10) Helping parents manage chronic disease in the community, and 11) Helping new fathers.

The aims of this study are to investigate the safety and acceptability of reducing the frequency of outpatient clinic visits from 3 months (standard of care) to 6 months (intervention group) in people with cystic fibrosis (pwCF) on high-efficacy modulator (HEMT). We hypothesise that 6 monthly routine clinic visits will be non-inferior to 3 monthly visits (current standard of care).

This study aims to mitigate nephrotoxicity and enhance the therapeutic benefits of Lutetium-177 PSMA-I&T treatment by introducing an amino acid infusion as a renal protective measure. Who is it for? You may be eligible for this study if you are an adult male with confirmed prostate cancer and considered for ongoing treatment with 177Lu–PSMA-617. Study details: Participants will receive an amino acid infusion before their 4th, 5th, or 6th treatment cycle. Renal dosimetry will be assessed using 3D SPECT/CT imaging after this cycle and compared to the renal dosimetry of the same patients at the preceding cycle without amino acid infusion. It is hoped that findings from this study will help establish a protocol to reduce renal toxicity in patients undergoing radiotheranostics, thereby improving patient outcomes and safety profiles.

The aim of this study was to investigate the potential efficacy of the MOVERS Professional Development Program on children's physical activity, fine and gross motor skills and numeracy and literacy skills and the quality of the movement environment. It was hypothesised that at the end of the 6 month professional development program, that children in the intervention group would have significant increased in physical activity, fine and gross motor skills and numeracy and literacy skills compared to those in the control group. Additionally it was hypothesied that the quality of the movement environment would increase in the intervention group compared to the control group.

The purpose of the study is to understand whether a supervised or a self-directed frailty program can slow frailty in older adults. We know that building muscle strength, eating a balanced diet and checking medications is best for healthy aging. We also know that being social or connecting with others can help improve or maintain quality of life. Both the supervised and self-directed programs are based on current clinical guidelines and best practice and include help with things we know can help slow or reduce frailty - exercise, diet, checking medicines, and social support and engagement. The study will also look at how easy these programs would be to put into practice in the real world, and to assess the cost of doing so. This study will be conducted in most states of Australia with a total of 390 participants Australia-wide.

There is an increasing body of evidence demonstrating the safety and efficacy of subcutaneous (SC) administration of antibiotics. This is a prospective single arm cross over design study aims to extend our experience with subcutaneously administered antibiotics by determining the safety and tolerability of subcutaneous administration of 2g of ceftriaxone. Inpatients already receiving ceftriaxone 2g to treat an infection will have dry blood spots (DBS) collected immediately prior to an intravenous dose and at several time points subsequently over the dosing interval to measure the antibiotic concentrations in bloods. They will then have DBS collected at the same time points with a single dose of ceftriaxone 2g administered via subcutaneous infusion. Patients will be closely followed throughout the study with detailed safety and tolerability assessments completed. We hypothesise that the administration of 2g subcutaneous Ceftriaxone will be safe and well tolerated with equivalent bioavailability to intravenous administration of the same dose.