ANZCTR search results

Audit comparing amount of nursing time taken and accuracy of blood glucose levels recorded in the electronic medical record for the standard Nova Biomedical glucose meter currently used for clinical care compared with the AMSL wi-fi connectivity Statstrip glucose meter. Nova Biomedical manufactures a wi-fi connectivity glucose meter which can upload its glucose data directly to the patient electronic medical record (eMR). We anticipate that using the wi-fi connectivity glucose meters will substantially save nursing time and also contribute to an increase in the accuracy of glucose recording in the eMR. We plan to compare the time taken to check and record in the eMR a finger prick glucose level using each glucose meter type and to determine the proportion of glucose levels recorded accurately in the eMR by each technique (correct patient, correct time, correct glucose level and delay to glucose being documented in the eMR).

This study aims to compare the effects of two nut ingestion patterns, vs. no nut intake, on the 24-hour blood glucose homeostasis of adults with type 2 diabetes (T2DM). We hypothesise that nuts, when evenly distributed across three main meals, will result in better blood glucose control over 24 hours than when consumed only with breakfast in individuals with T2DM. We further hypothesise that both nut ingestion patterns will be better than a diet without any nuts.

Cognitive behavioural therapy (CBT) sleep interventions for non-clinical sleep symptoms have positive impacts on sleep quality and quantity and better participant engagement than other lifestyle interventions. This study is a pilot randomised controlled trial (RCT) that aims to test the feasibility of a sleep CBT intervention compared to a minimal intervention for improving sleep and lifestyle in women with PCOS. This would help inform a larger trial to test the hypothesis that women with PCOS are more likely to maintain improved lifestyle (diet, physical activity and sedentary behaviour) if they are obtaining adequate and good quality sleep.

Deep brain stimulation (DBS) is an established efficacious treatment to reduce symptoms associated with neurological conditions such as Parkinson's disease, essential tremor and dystonia. The success of DBS relies on accurate electrode lead implantation and targeted DBS stimulation. Biosignals, such as evoked resonant neural activity (ERNA), provides additional information to clinicians that may assist in optimising DBS treatment. This study aims to explore the reliability of biosignals collected during DBS implantation under multiple conditions and their utility in optimising DBS treatment.

CBT-AR describes an adaption of cognitive behavioural therapy for use with individuals diagnosed with Avoidant/Restrictive Food Intake Disorder (ARFID). The purpose of this evaluation is to determine the feasibility, acceptability and efficacy of this treatment. It is hypothesised that this treatment will be feasible and acceptable to clinicians, carers and patients and will be effective in reducing symptoms of ARFID for patients.

The study aims to investigate the effects of different plant extracts on prolonging satiety in healthy overweight adults. This study utilizes a randomized, double-blinded, crossover design to investigate if specific plant extracts can reduce appetite and increase feelings of fullness. Participants will attend an initial screening and five treatment sessions at the BASE Facility. The primary goal is to understand if these extracts affect how much people eat at lunchtime, while secondary outcomes assess changes in appetite through questionnaires.

This study is to evaluate the potential of tumour organoid response to predict the clinical benefit that individual patients will derive from available anti-cancer therapies for advanced CRC, in the first- and later-line therapy settings. Who is it for: You may be eligible for this study if you are an adult male or female with a diagnosis of CRC that is either locally advanced and unresectable, or metastatic, have not received treatment (ie chemotherapy) for this stage of disease and otherwise are fit enough to undertake treatment. Study details: The study will involve obtaining biopsies initially and at time of progression and using standard and novel blood tests. The consistency of results between expanded panel (TSO500) based testing of tumour tissue and laboratory-based profiling of the matched PDTO will be examined. It is hoped that these results will help improve decision making by clinicians and ultimately individualise patient's treatment to improve outcomes. Patients will receive standard of care treatment at the discretion of their Oncologist. (this is standard practise, done for those not participating in clinical trials also). It is hoped that findings from this study will establish reliable preclinical models that will enable high throughput drug testing to guide optimal treatment selection in daily clinical practice in the future, and potentially inform treatment selection of standard of care agents in first and later line treatment.

Population: Women giving birth to Aboriginal children participating in the Aboriginal Family Birthing Program (AFBP) at the Women’s and Children’s Hospital (WCH), Adelaide and through Child and Family Health Centres (CaFHS), SA. Study design: Mixed methods: qualitative (consultations with young Aboriginal women, community members and service providers), and continuous quality improvement (Plan-Do-Study-Act (PDSA) cycles) involving nutritional support and health literacy. Interventions: Culturally appropriate, intensive multifaceted intervention strategy to promote healthy eating embedded in SA AFBP/CaFHS, centering around 9 ‘mother and baby bundles’ given to participating families by Aboriginal Maternal and Infant care workers and CaFHS staff at key points in pregnancy and the first 12 months postpartum, refined through PDSA cycles. Comparisons: Routine data from past AFBP clients and their babies. Outcomes: Increase in proportion of women with healthy gestational weight gain and healthy postpartum weight, improved dietary changes (e.g. increased vegetable consumption), increased engagement and satisfaction with the program, improved nutritional status, higher rates of breastfeeding and improved infant health and growth. Significance: This intervention strategy will identify effective and sustainable ways to engage young women (and partners/children) in making healthy food choices, in managing weight, and in reducing obesity and associated short, long-term and intergenerational issues.

We developed an eHealth solution – Music Attuned Technology for Care via eHealth (MATCH) – to support carers of PwD to use music intentionally to support care. The mobile application was developed as an extension of an in-person music intervention training program (HOMESIDE - ACTRN12618001799246) which involved a qualified music therapist offering one on one training to carers in the intentional use of music. In this feasibility study (Study 4), we will: a) evaluate the adherence, usability, and acceptability of MATCH for PwD and their CGs community setting. b) explore the clinical and health economic impact associated with engagement with the MATCH solution, especially on agitation, quality of life, and care burden. c) explore adherence, usability, and acceptability of MATCH for PwD and their CGs during the transition between community setting and RAC.

This study aims to examine the impact of a naturally occurring polyphenol extracted from tea on blood uric acid levels in healthy adults. Researchers will administer the polyphenol to participants and monitor changes in their uric acid concentrations for 6 weeks treatment. The goal is to determine if this tea-derived compound can effectively lower uric acid levels. The study will provide valuable insights into the potential health benefits of tea polyphenols.