ANZCTR search results

To see the tolerance patients have after a general anaesthetic of nasal oxygen as opposed to facemask oxygen (which is normal). Previous studies show that compliance with oxygen therapy is better with nasal oxygen than facemask oxygen. Also we believe this technique gives patients as effective oxygenation. Therefore potentially improving patient safety.

This randomized comparison trial will test the efficacy of a novel rehabilitation (Move it to improve it' (MiTii) which involves the use of a web based, intensive, individualized, multi-modal therapy program with therapists acting as virtual trainers, over a 20 week period, and comparing this approach to standard care received in children with acquired brain injury.

The strongest risk factor for depression is having a family history of the condition. Many individuals with a family history of depression are concerned about their personal risk for depression. In this study we will develop and evaluate the first online psycho-educational intervention nationally and internationally targeted to individuals with a family history of depression. An intervention incorporating a risk assessment tool and delivery of education tailored to people with a family history of depression will be developed and pilot tested. The intervention will be delivered by general practitioners (GPs) and evaluated using a cluster randomised controlled trial (RCT) methodology.

BIT225 powder has been used in several trials to date to investigate safety and effectiveness. A capsule formulation, being a more acceptable dose form than the powder, has been developed for use in future trials and as a possible future marketed formulation. This trial is to compare a single dose of the capsule to a single dose of the powder to see how much of the drug gets into the bloodstream and how long does the body take to remove it, what is the maximum concentration of the drug in the bloodstream after a single dose, and how well the capsule is tolerated compared to the powder form.

The purose of this study is to understand how well oxycodone in combination with tocopheryl phosphate mix (TPM), is absorbed through the skin and into the bloodstream, with the use of a patch.

Heart disease is the leading cause of death in Australia, and patients with existing coronary heart disease (CHD) are at increased risk of further cardiac events. Most secondary prevention guidelines recommend that patients with CHD modify their cardiac risk factors. To do this, patients require an adequate level of health literacy including awareness of their own condition and risk factors, and the knowledge to be able to make essential lifestyle modifications. The Heart Foundation recently updated a key resource My Heart My Life, which provides comprehensive information on recovery from heart disease. This project seeks to evaluate the effectiveness and impact of the My Heart My Life resource on patient knowledge, behaviour change and health literacy in Victoria. Patients who have been admitted to Eastern Health with an acute coronary syndrome (ACS) will be asked to complete a Health Literacy Questionnaire (developed by Deakin University). Questions will also be asked to determine understanding of terminology and actions to take to reduce health behaviour risk factors. Participants will then be randomised into two groups – one group who receive the My Heart My Life resource and a control group who receive usual in-patient education. A follow-up phone call will be done at one month to determine differences between the two patient groups in terms of cardiac knowledge and health-related behaviours. The results of this evaluation will determine whether patients who received the My Heart My Life resource obtain a greater understanding of their condition, report they are able to manage risk factors and are more likely to attend cardiac rehabilitation, compared with usual care.

More than one in ten infants are born preterm, with increased risk of disability. To guide public policy reliably, cost-effectiveness analyses of interventions to prevent disability require a long-term societal perspective, including costs of hospital treatment, special education, family or community care, and lost parent and child productivity. Methods: We evaluated (i) the proportion of cost effectiveness analyses with a long-term societal perspective and (ii) whether analyses with a long-term societal perspective were more frequent within randomised controlled trials (RCTs). Original, peer-reviewed research articles in English from 1 January 2002 through 31 December, 2012 were eligible for inclusion in the review if they described cost-effectiveness analyses of interventions before or after preterm birth and reported disability. Searches by two reviewers in The Cochrane Library, EconLit, EMBASE and MEDLINE databases yielded 220 articles. Reference lists from those articles yielded another 5 articles. Of these 225 articles 25 described cost-effectiveness analyses that met the inclusion criteria.

This study is evaluating the effect of an intervention aimed at promoting earlier symptom appraisal and help-seeking for people at higher risk of lung cancer. Who is it for? You may be eligible to join this study if you are aged between 55-90 years and have smoked at least one packet of cigarettes daily for a period of 20 years (i.e. 20 pack years). This includes ex-smokers if your cessation date was less than 15 years ago. Trial details: Participants in this trial will be randomly (by chance) allocated to one of two groups. Participants in one group will receive standard care, whilst participants in the other group will be offered the CHEST intervention. This is theoretically based and comprises a 40 minute primary nurse consultation to discuss and implement a self-help manual, followed by monthly self-monitoring reminders by either, email, text message or phone call. Participants will be monitored for 12 months to evaluate the effect of the intervention on consultation rates and time to consultation for chest symptoms.

This study is designed to determine whether the use of the CIVCO (Registered Trademark) ultrasound needle guide (Infiniti, CIVCO Medical Solutions, Kalona, Iowa, USA) will improve visualisation of the needle tip during ultrasound-guided TAP blocks when compared with the “free hand” technique for patients undergoing major abdominal surgery. Furthermore, we aim to study whether it will shorten the procedural time, improve operator satisfaction or lead to increased dermatomal blockade.

This project will evaluate an integrated 'chronic disease self-management' (CDSM) education program for people with type 2 diabetes mellitus. The program is constructed around a patient manual, the working through of which is facilitated by a trained health coach over a 7 week period. The manual provides key information about disease management and skills training. Using the "Whole Person Model" the manual encourages the reader to consider how their body, their thoughts and feelings, and their health behaviours all affect each other. It helps people look at their thinking and learn strategies to improve their mood and make lifestyle changes. The aim of the proposed project is to evaluate, through a randomised controlled trial, the efficacy of the program. It is hypothesised that people allocated to the intervention (completion of the program) will demonstrate greater improvements in self efficacy in their disease management, health outcomes, well-being and quality of life than the control group.