ANZCTR search results

The main aim of this study is to assess whether one on one education and training of patients in pressure injury prevention will prevent pressure injury. The 3 key messages are; i) keep moving, ii) good skin care; and iii) good nutrition.

In this proof of concept study, we aim to demonstrate that CEA may be successfully produced from our laboratory and used in the clinical setting. With our strategy in the application of CEA sheets, we can match or better the quality of care previously provided by our unit, and other burn centres around the world.

Awake fibreoptic intubation is a method to enable intubation in patient with difficult airways. To ensure safety of the patient, awake fibreoptic intubation may be required. Previous studies have shown that this process can be a cause of anxiety in patients. The aim of this study is to investigate whether the use of a video to demonstrate the process will alleviate anxiety in this group of patient. The study will be a randomised controlled trial. The control group would have the process explained to them verbally and in the form of a leaflet. The study group will, in addition to verbal and leaflet, be shown a video on the process. A questionnaire will be used prior to the explaination to assess the level of anxiety and the questionnaire will be repeated after the operation twice The data collected will be analysed using appropriate statistical method.

To investigate the effects of bFGF on treatment of chronic ear drum perforations

This anonymous online questionnaire consists of two surveys completed by participants after agreeing to participate and for use of their responses to be reported in a journal. Survey A is a randomised study of different versions of an information leaflet describing a hypothetical clinical trial in preterm infants. The hypothesis is that different types of wording in 3 sections of the leaflet using negative, neutral or positive language will influence respondents' understanding, anxiety and willingness to participate. Survey B is a randomised 3 arm study of the effect of providing online participants with (i) a video versus (ii) a written transcript of the video versus (iii) no information will influence respondents' understanding, anxiety and willingness to participate.

This is a study of anal (HPV) infection and related anal disease in gay men. Both HIV positive and HIV negative men are eligible. You should not have been previously diagnosed with anal cancer. All participants in this study will undergo high resolution anoscopy during the study over 36 months. The first HRA will be conducted at Baseline and at all 4 follow up visits. The high resolution anoscopy involves, examination of the peri-anal region and perineum, and the a plastic anoscope is inserted into the anal canal. Following staining of the anal canal with acetic acid and lugol's solution, the anal canal is visualised under high resolution magnification. Biopsy samples will be taken by the clinician for histological assessment if there are any detected abnormalities. The data collected from these examinations will be used to determine the prevalence, incidence and risk factors for specific types of human papillomavirus (HPV) infection. There are more than 100 type of HPV. Some cause genital warts and other types cause more than 90% of anal cancer. Gay men are over 20 times more likely than others to develop anal cancer. The information collected in this study may guide the possible future introduction of anal cancer screening programs for gay men.

Previous research has found that people with subsyndromal depression, (those who have symptoms of depression but do not meet criteria for clinical depression), are significantly more likely to develop clinical depression within one year compared to those without subsyndromal depression. Research has shown that Cognitive Behavioural Therapy (CBT) is the most successful psychological intervention to treat depression to date. The theory behind CBT for depression suggests that depressed people have more difficulty than non-depressed people keeping their attention away from negative stimuli and are also more likely to interpret vague and unclear stimuli in a negative way. Research has shown that people at risk of developing depression, including those with subsyndromal depression, also seem to display this attentional bias to negative information. Cognitive Bias Modification (CBM) is a relatively new therapeutic technique that aims to shift dysfunctional biased beliefs through using a computer based program. Recent research using the CBM approach has been promising in reducing symptoms of depression. However it is unknown how effective CBM is in preventing clinical depression from developing in those with subsyndromal depression. Therefore this study aims to determine if CBM decreases the 1-year onset of a major depressive episode among adults with subsyndromal depression.

This study's purpose is to generate preliminary data on the efficacy of the addition of dry needling to standard physiotherapy management in the treatment of headaches, as well as to determine the feasibility of running an efficacy trial for this condition. This will involve the collection of a small set of data on the efficacy of dry needling for headaches, and to determine the feasibility of running a trial collecting this data. This will allow determination of a sample size estimate, the availability of eligible participants, the willingness for subjects to be recruited, and adherence rates to management, enabling evaluation of the feasibility of a future successful, cost-effective large-scale efficacy trial. We hypothesise that: 1. An efficacy trial is a feasible means to study the impact of dry needling on cervicogenic and tension-type headache 2. Standard physiotherapy plus dry needling changes the severity, frequency and disability of cervicogenic and tension-type headache pain in adults

Clinical Treatment of Venous Ulcers using Autologous Stromal Vascular Fraction Isolated from Lipoaspirate INTRODUCTION Stromal vascular fraction (SVF) harvested from lipoaspirate consists of a heterogenous mixture of cell types including adipose-derived stem cells (ASC), fibroblasts and endothelial cells. There is evidence to suggest that the cells contained in SVF have angiogenic and regenerative properties that may be effective in treating venous ulcers. OBJECTIVE The goal of this study is to determine the effectiveness of autologous stromal vascular fraction (SVF) from lipoaspirate for the treatment of venous ulcers. METHODS Prospective randomized controlled study of patients from Royal Adelaide Hospital with venous ulcers on their leg. Autologous lipoaspirate will be collected from all patients using syringe aspiration from a healthy donor site. Group 1 will have their lipoaspirate sample centrifuged in the operating theatre and subsequently injected into the wound. Group 2 will have their lipoaspirate sample processed in a sterile laboratory to isolate the SVF and subsequently injected into the wound. Group 3 will have no injection. The primary outcome measured will be time to complete wound closure. CONCLUSION The results of this study will be statistically analysed and summarised, will be presented at a plastic surgery conference, and will be submitted for publication in a peer-reviewed journal.

A Randomized, Double-Blind, Placebo Controlled, Multiple Ascending Dose Study to Evaluate the Safety and Tolerability of Nexvax2 in Patients with Celiac Disease. Primary objective: *To determine the safety and tolerability of Nexvax2 when administered intradermally to human leukocyte antigen (HLA)-DQ2.5+ patients with celiac disease on a gluten free diet (GFD) Secondary objectives: *To assess the pharmacokinetics (PK) of Nexvax2 when administered intradermally to patients with celiac disease on a GFD *To assess the effect of Nexvax2 on the immunological response and on clinical tolerance to gluten when administered intradermally to patients with celiac disease on a GFD Exploratory objective: *To assess the effect of Nexvax2 on small bowel mucosal histology in patients with celiac disease on a GFD