ANZCTR search results

The aim of this study is to determine the effectiveness of Smartphone application technology as a brief primary care intervention to increase sustained physical activity levels and decrease the risk of developing type 2 diabetes. 30 participants over the age of 35 who are at high risk of developing diabetes will be selected. Participants diabetes risk will be calculated using the AusDrisk tool. The participants will be divided into two randomised groups. The active intervention group will be introduced to the Smartphone application while the Control intervention group will not. The participants weight, height, waist circumference, blood pressure and AusDrisk score will be measured in both groups at weeks 12, 26, 38 and 50. The anticipated outcome for the project is a measurable increase in the physical activity and decease in AusDrisk score in the active intervention group compared to the control intervention group.

Warming up is considered an integral part of pre-performance preparation in sport and music, and yet little information exists on how to best prepare to play. As such, this study will investigate the effects of core muscle, general cardiovascular, and on-instrument warm-ups on upper extremity and core muscle activity during violin performance. Additionally, the effects of the three warm-ups on participant audible performance quality will be analysed. It is predicted that both the use of warm-up and the mode undertaken will have a variable positive effect on muscle activity and sound quality.

The major mechanism of action of GLP-1 agonists in lowering post-prandial glycaemia is their ability to slow gastric emptying. Acute hyperglycaemia itself is known to slow gastric emptying substantially and it is likely that many patients will be hyperglycaemic at the time of GLP-1 administration. If GLP-1 does not further slow gastric emptying during marked hyperglycaemia then it is likely the agonists will have only a minimal effect to attenuate postprandial glycaemia. The latter observation would support a rationale to reserve GLP-1 agonists until fasting glycaemia is reduced, eg. by initial insulin therapy, whereas if the hypothesis is rejected then GLP-1 agonists would be a rational choice as single agents even in patients with marked fasting hyperglycaemia. Accordingly, it is important to determine whether hyperglycaemia per se affects the capacity for GLP-1 to slow gastric emptying.

The purpose of this study is to determine the optimum dose of exogenous glucagon-like peptide-1 (GLP-1) with stepped administration; and evaluate the effects of GLP-1 on gastric emptying, mesenteric blood flow and glucose metabolism when compared to exogenous insulin.

Few patients admitted to the intensive care unit (ICU) have a previous record of directly measured BP during nighttime or resting (hereto referred as basal) state. Therefore, the usual hemodynamic targets in ICU are broadly based on values relevant to the general population. Individualising these targets could vastly improve management of critically ill patients. A validated protocol to estimate a patient’s baseline BP would enable this tailored therapy for the patients. The main purpose of this study is to assess the agreement (or the difference) between a protocol-estimated value and a directly measured value for the resting BP in a cohort of patients who recently underwent direct measurements of their resting arterial BP. In this study, we hypothesise that the directly measured and protocol-estimated BP values will correlate well with minimal bias.

Few studies have investigated how to improve parents' understanding of clinical trials they are asked to join or how to reduce any possible distress. The INPUT study proposed will explore the effect of positive, negative or neutral language on parents' understanding, stress and willingness to participate in clinical trials.

To assess the visual performance of multiple prototype soft contact lens designs.

This study will evaluate the prognostic value of assessing hypoxia (low oxygen) in cervical and lung tumours using FMISO-CT/PET scans throughout a course of radical chemoradiation therapy. Who is it for? You may be eligible to join this study if you are aged 18 years or above and have been diagnosed with either cervical cancer or non-small cell lung cancer (NSCLC), for which your are scheduled to undergo a course of radical radiation therapy with or without chemotherapy. You should not have received any previous radiotherapy or chemotherapy for the cancer, or have any evidence of distant metastases. Study details All participants in this study will be treated as per standard of care with the addition of 3 FMISO-PET scans which will be done prior to treatment (baseline), 2 weeks into radiation therapy and 2 weeks after completion of radiotherapy. Each FMISO-PET/CT scan will take approximately 60 minutes. During this time an intravenous cannula will be inserted into your arm and contrast injected. PET scans pose a small health risk as they involve exposure to radiation. The dose from this study is comparable to that received from many diagnostic medical x-ray and nuclear medicine procedures. The aim in this proof of concept study is to demonstrate that we can non-invasively and safely use 18FMISO-PET on 2 cohorts of patients (cervix and non-small cell lung(NSCLC)) whose tumours are known to be affected by hypoxia and explore the tools to measure the PET images to objectively evaluate the hypoxic region within the tumour throughout a course of radiation therapy.

The aim of this study is to assess the efficacy of a probiotic preparation in improving glucose metabolism and metabolic markers in adults with pre-diabetes and recently diagnosed with T2DM. Moreover, gut permeability, faecal and metabolomic profiles will be measured to evaluate a potential mechanisms of action of the multi-strain probiotic. We hypothesize that the administration of an evidence based probiotic preparation may modulate the GI microbiota from a dysbiotic to a balanced state improving blood glucose levels, decreasing inflammatory markers and endotoxaemia, and improving lipid profiles.

With the ageing of the population, the number of people entering the last stages of life will increase rapidly in the coming few years. Most people will die of progressive, non-malignant disease and most will never be reviewed by a specialist palliative care team, in spite of the intensity of many peoples' needs being equivalent to those dying of cancer. This study aims to improve the care of people dying of non-malignant disease, by conducting a case conference between the patient's GP, their specialist heart failure or lung health nurse, and a palliative care specialist. The purpose is to conduct a comprehensive case review, and develop a clear care plan with clear allocation of tasks. We will compare service utilisation after the conference with that of the previous 12 months, patient outcomes, carer outcomes, and a health economic analysis. This project is a pilot and will lead to a formal randomised controlled trial.