ANZCTR search results

The CORD study is a pilot study aiming to determine the feasibility of reinfusing cord blood in children who are at risk of developing type 1 diabetes. The hypothesis is that autologous cord blood, when reinfused into children at high risk of developing type 1 diabetes, will resotre immune tolerance and prevent or mitigate the development of type 1 diabetes. Participants aged 1-12 years with a relative with type 1 diabetes will be tested every 12 months for the development of islet antigens. Following screening, a target treatment group of 20 with two or more autoantibodies, will receive an infusion of their autologous cord blood. Participants will be followed for 5 years or until they develop diabetes.

This study will assess the efficacy of the 'Supporting Men, Supporting Women' website in providing information for men supporting women through genetic testing for breast/ovarian cancer. It aims to help men understand and cope with genetic testing, and communicate and support women throughout this process. We expect that individuals accessing this website will have low levels of distress, feel satisfied with the extent of support offered and received in their relationship, have high knowledge of genetic testing and feel satisfied with genetic information.

The impact of dementia on family caregivers is substantial. Building on growing clinical interest in the capacity for Transcendental Meditation [Registered Trademark] (TM; a deep relaxation technique) to reduce stress and anxiety in healthy workers, this pilot RCT will examine whether similar improvements could be experienced by dementia caregivers. Specifically, the study will explore whether a TM program can improve psychological stress, quality of life, affect and cognitive performance of dementia caregivers when compared to wait-list control.

This study aims to evaluate the efficacy of group Enhanced Cognitive Behaviour Therapy (CBT-E) for eating disorders in adults. It is hypothesised that, on average, group CBT-E will result in significant pre- to post-treatment improvements in eating disorder symptoms and in symptoms relating to perfectionism, low self-esteem, mood intolerance and interpersonal problems. It is also hypothesised that group CBT-E will be significantly more effective than a waitlist control condition in producing changes in symptoms.

This is a prospective, randomized, single-blinded study to observe subject safety and measure efficacy of the Tonsil Dressing in the treatment of subjects post-tonsillectomy. Up to 36 subjects will be enrolled at up to 6 Australian investigational sites. Subjects will be randomized 2:1 (test:control). Tonsillectomy performed using electrodissection monopolar diathermy (10-15W). Subjects will complete self-assessments of pain (2x/day), activity and nutrition levels for 14 days. Clinic follow-up visit between days 15-25.

This research project will compare a new intensive upper limb rehabilitation approach (COMBiT- combined constraint induced movement therapy and bimanual therapy) with standard care individual occupational therapy for children with congenital hemiplegia.

Falls are common in the population aged 65 years and over and present a major challenge to older people, health care providers and the health system. Over one third of community dwelling people in this age group fall each year and the rate of falling is even higher in residents of aged care facilities. There is now extensive evidence to demonstrate fall rates can be reduced using exercise. Programs that target balance and lower limb muscle strength appear to be most successful however the vast majority of research has focused on community dwelling adults. The results of trials into exercise on falls prevention in residential care are inconsistent. This randomized controlled trial will test the efficacy of an exercise intervention that combines key components of programs from successful community based research on residents of long term aged care. The primary outcome will be falls (fall rates and number of fallers). Quality of life, mobility, and fear of falling will also be measured and a cost benefit analysis will be performed. Outcomes from this study have the potential to impact on a substantial individual and international healthcare problem.

This study aims to investigate the benefits of yoga in the reduction of depression and anxiety, and associated increases in positive emotions, well-being and mental health.

This study aims to examine the incidence of cognitive and affective problems after joint replacement surgery. These outcomes will also be placed into context of post-surgical pain and quality of life. The potential moderating role of cognitive reserve will also be assessed. The specific aims of the study are to: a) Define the incidence of short- and long-term cognitive dysfunction, depression and anxiety following joint replacement surgery. b) Determine the potential moderating role of reserve on these poorer outcomes. c) Identify the predictors of these poorer outcomes, with specific reference to quality of life, pain, and chronic medical conditions

Corticosteroids (CS) are anti inflammatory agents and are frequently used in neurosurgical and neurological practice: they are a routine adjunct to surgery in patients with brain tumours worldwide. Several clinical studies have also demonstrated the utility and safety of CS as an alternative to surgery with CSDH: however, most studies have merely compared CS as ‘medical versus surgical management’. Only one study has directly compared the effects of CS as an adjunct to surgery: although a null effect was observed, the ‘surgery alone’ group consisted of only 13 subjects; and the study was not randomised. We propose to perform the first prospective, randomized, placebo-controlled double-blind clinical study of surgery for CSDH with and without corticosteroids as an adjunct. We aim to see whether surgery plus CS might reduce operative recurrences, in-patient stay and mortality.