ANZCTR search results

Reviews of the literature show limited evidence for the efficacy of conservative management of patients with carpal tunnel syndrome and a lack of studies investigating the long term effects of the non-surgical management of patients with carpal tunnel syndrome. The aim of our study is to investigate the long-term efficacy of a multimodal approach comprising of manual mobilisation techniques, education and nerve and tendon gliding exercises (MEX) versus therapeutic ultrasound treatment in managing carpal tunnel syndrome. Hand splinting is included as an adjunct intervention to evaluate its influence on the 2 treatment approaches. We hypothesise that the MEX treatment approach would be superior to therapeutic ultrasound treatment in the long-term and the addition of hand splint in either treatment would improve its overall outcome.

This RCT will evaluate the acceptability and efficacy of a combined CBM + internet-based CBT program for depression by comparing an active CBM intervention with a control comparator.

The Myeloproliferative neoplasms (MPNs) have until recently been under-represented in malignant haematology research. Recent major developments in understanding MPN biology and emerging new pharmaceutical agents have resulted in MPNs being a major growth area for both basic/translational research and clinical trials. Currently there is no systematic approach to collecting data on numbers of MPN patients and the current standards of care of these patients in Australia and New Zealand. This information is vital for planning and feasibility assessments for future clinical trials. A well-constructed database will generate essential data and be a major resource for translational research, particularly if patients in the registry also consent to ALLG tissue banking. Investigators with an interest in a specific subset of MPN patients will be able to query the database for a list of such patients and their characteristics. Patients will be entered into the database either retrospectively (for certain diagnoses and some sites) or prospectively, at diagnosis, with annual follow up.

Recently, data from observational (AusDiab) and experimental (IDLE breaks study) research indicates people who break up their sitting time throughout the day with light-intensity activity (such as light walking) may have better blood glucose and blood fat levels than people who sit for prolonged periods without activity breaks. This experimental study will examine the acute effect of prolonged sitting with and without light intensity activity bouts on memory functions (long-term and short-term memory and executive functions) in adults. Nineteen sedentary overweight/obese adults aged between 45-75 years will be recruited to attend two separate trial days interspersed by a one week washout period: control condition (sitting – 7 hours), a similar duration of sitting but with 3 minute light intensity activity bouts every 30 minutes. Cognitive testing, measurements of neurotrophic, metabolic, inflammatory, cortisol and catecholamine markers will be conducted. The proposed study will provide initial insights into whether breaking up sitting time with intermittent light-intensity activity has the potential for cognitive benefits whilst also describing the acute cognitive effects of prolonged sitting.

This studies aims to compare blood vessel elasticity after two protein-rich meals which are high in either olive oil or palmolein (further purified fraction of palm oil). The study also aims to compare the effect of these test meals on blood markers of heart health.

The purpose of this study is to assess the utility of a simple device that reduces coronary contrast reflux in STEMI patients undergoing percutaneous coronary intervention. The safety and efficacy of this device has recently been demonstrated in Alfred Hospital Study a performed at The Alfred Hospital (Project 347/12) in patients undergoing routine coronary angiography and non-acute PCI. This study showed that the device reduced overall contrast requirement by approximately 40%.

This study will assess the effectiveness and feasiblity of a newly developed brief intervention for young persons with cancer termed Mindfulness-Based Music Therapy (MBMT). Who is it for? You may be eligible to join this study if you are a cancer survivor aged 14 to 25 years old, or are actively attending treatment at metro Adelaide hospitals. Participants must be fluent in English. Trial details All participants in the study will undergo at least two sessions with the music therapist. During meetings with the music therapist, participants will learn some attention focusing techniques ("mindfulness") and music therapy techniques. Participants will also be provided with some pre-recorded songs and voice recordings to practice the exercises at home on a regular basis. Participants will be asked to complete questionnaires at baseline, 2 weeks and 8 weeks after the intervention completion in order to evaluate psychological wellbeing across the cancer journey. The intervention is expected to decrease psychological distress, and improve quality of life, mindfulness and self compassion.

A Phase I, Open-label, Dose-escalation Study of the Safety and Pharmacokinetics of HMPL-504 in Patients with Advanced Solid Tumors. You may be eligible to join this study if you are aged 18 years or more and have been diagnosed with incurable, locally advanced, or metastatic solid malignancy that has progressed on, or failed to respond to, at least one prior systemic therapy. Trial details Participants in this trial will be allocated to take Volitinib (HMPL-504) tablets once daily for a period of [a cohort /21 days] at one of six dose levels (100, 200, 400, 600, 800 or 1000 mg/day). Patients will be assigned to dose levels sequentially as they are enrolled. Participants will be assessed for up to 20 months in order to determine safety and tolerability of the treatment. They will also be asked to give blood samples to assess the pharmacokinetics (i.e. action of the drug in the body) over a 21 day period.

Advanced glycation endproducts (AGEs) are formed within the human body as a normal consequence of metabolism, but their formation is accelerated in people with elevated blood glucose levels such as those with diabetes. Excessive AGEs are known to have negative effects within the body including contributing to kidney damage, stimulating inflammation and promoting changes in blood vessels which lead to heart disease. AGEs have been shown to contribute to the development of the complications of diabetes and more recently it has been hypothesised that AGEs may play a major role in the development of type 2 diabetes. Simple therapies aimed at reducing the progression of inflammation and insulin resistance are urgently needed to prevent or slow type 2 diabetes development in susceptible individuals. Dietary supplements (called prebiotics) which promote the growth of beneficial bacteria in the human bowel have been shown to reduce inflammation and improve insulin resistance, but their effect on AGEs is unknown. Taking a daily prebiotic dietary supplement which stimulates the growth of beneficial bacteria in the human bowel might offer protection against AGE-related pathology in people at risk of developing type 2 diabetes. This study aims to determine the effect of 24-week consumption of a prebiotic dietary supplement on tissue AGE (advanced glycation endproduct) levels, insulin resistance and inflammatory biomarkers in adults with pre-diabetes in comparison to those receiving a placebo supplement.

The current standard of practice for the treatment of CRS includes antibiotics either given by mouth or through an injection in your arm, nasal sprays and rinses, oral and nasal corticosteroids and/or anti-allergy medicines. Despite these treatments some patients are still unable to get relief from their sinus symptoms. When the above treatments fail and the disease continues then some patients will move forward to surgery. This type of surgery is called “Functional Endoscopic Sinus Surgery (FESS)”. The surgery is quite difficult and requires great surgical skill. One of the problems associated with FESS surgery is making sure that the area being treated is clear of blood so the surgeon can see the area he is treating. There are a number of complications associated with bleeding with this type of surgery which your doctor will explain to you. A potential solution to try and improve the visibility when performing FESS surgery is to use laser throughout the procedure. Laser is used in many types of surgery, including surgery for ears, nose and the throat (otolaryngology). The laser being tested during this study is a new laser. It has been designed so that it delivers the laser through a much smaller fibre (a tube that delivers the light to the tissue) and also uses very low power to avoid unwanted damage to nearby healthy tissue, which will hopefully help achieve better results from surgery and also fewer complications with this type of surgery. This study is being done to look at the safety and the performance of this new laser when it is used during FESS procedures. It is important to remember that you would have undergone the surgery regardless of this new laser – the new laser is an additional treatment being used during the procedure.