ANZCTR search results

The purpose of this randomised controlled trial is to determine if the use of a decision aid by drivers with dementia results in improved decisional uncertainty/conflict. It will also involve establishing if the decision aid booklet improves participant knowlege and decisional satisfaction. Booklet use, acceptability and impact upon decision will also be evaluated.

Complicated grief shares a number of common features with post traumatic stress disorder (PTSD), which is often treated using eye movement desensitisation reprocessing (EMDR). Given the similarities between PTSD and complicated, there is hope that EMDR may also be effective in treating complicated grief. To date, only one study has documented the results of EMDR with grief client. Although the findings indicated a potential economic benefit in terms of shorter treatment times, the study described had limitations which prevented the results from being generalised. This study aims to explore the efficacy of Eye Movement Desensitisation Reprocessing (EMDR) in the treatment of grief by using a randomised controlled trial to compare it with a more traditional cognitive-behavioural therapy (CBT) approach. It will address methodological flaws of the only previous study of EMDR and grief by using random allocation to assign participants to treatment groups, as well as have participants act as their own wait-list controls prior to commencing treatment. Answers will be sought to the following questions: 1) Does EMDR for grief result in more beneficial treatment outcomes than CBT? 2) Is the rate of improvement significantly greater in the EMDR than the CBT treatment approach? 3) Do certain individual factors predict response to treatment? Based on previous studies, both groups are likely to experience significant reductions in the intrusions of unwanted memories, anxiety, and depression. In addition it is likely that they will experience significant improvements in quality of life and behaviours such as sleeping, positive memories of the loved one, avoidance of known triggers and nightmares at post-test (as measured by the Quality of Life Scale and a behavioural questionnaire). It is anticipated that the rate of reductions and improvements as detailed above will be significantly greater in EMDR participants compared to CBT participants. Relative to CBT, it is expected that EMDR participants will experience significantly greater reductions in the intrusive and avoidance effects of the loss, anxiety, depression and grief, and significantly greater improvements in quality of life and behaviours such as sleeping, positive memories of the loved one, avoidance of known triggers and nightmares at post-test.

Depression is a common mental health problem in people with diabetes and is associated with lower quality of life, poorer blood glucose control, and higher rates of functional disability, diabetes related complications and mortality. The internet is recognised increasingly as a useful way of increasing public access to evidence-based treatments for mental health problems. In a recent study, researchers at the Black Dog Institute showed that a new internet and mobile phone intervention, 'myCompass', improved significantly mental health outcomes for people with mild to moderate depression, stress and anxiety. The proposed study will examine whether use of myCompass improves mental health outcomes in people with diabetes, and is associated with improved self-managment and blood glucose control.

This study :Healthy and Unhealthy Eating Behaviours in Male Gym Users (18-65years)" is aimed at working with male gym users who have low self-esteem, poor body image and unhealthy eating behaviours. It is designed to provide them with education around body image and the influence of the media as well as the signs and sympomts of unhealthy eating behaviours.

Open Label Extension Study to Evaluate the Safety, Tolerability and Cognitive Effects of VEL015 (Sodium Selenate) in Patients with Alzheimer’s Disease

Skin cuts are common injuries sustained by children. There are two main to stitch cuts. The first method is to use stiches on the outside of the skin and the other method is to use a deeper stitch that would not be able to be seen on the skin surface. The purpose of this project is to study whether one of these two methods of stitching results in better healings of cuts. We do not know whether one method of closing facial skin cuts is better than the other. Both methods have their advantages and disadvantages. Stitches under the skin (or buried stitches) provide good support for facial wound closure while stiches on the skin (external stitches) have a lower risk of complications but may result in a more visible scar. Previous research studies on adults have found that the both buried and external stiches have healed in a similar fashion

The hypothesis is that the use of Aquablation will provide a clinically effective cutting and coagulation action on prostatic tissue without the need for thermal energy thereby reducing perioperative complications such as bleeding, catheterisation, shorter recovery time and dysuria. It is hypothesised that the more effective operative technique will provide an earlier improvement in patients' quality of life as evidenced by a reduction in symptoms, no deterioration of erectile dysfunction and improvements in peak urinary flow rate and post void residual volume.

Some adults with cerebral palsy have more difficulty with walking as they get older. Impaired balance and reduced balance confidence have been suggested to be contributing factors to this decline. This project will conduct a small randomised trial to examine the effect of a physiotherapy program of balance training on the walking self-confidence and balance of adults with cerebral palsy, compared to a different program of a variety of meditation, relaxation and lifestyle activities.

The main aim of this study is to compare two products for preventing or reducing the severity of radiation induced dermatitis (RID). RID is a common side effect of radiation therapy. RID is characterised by skin redness and in severe cases, the skin thins and begins to weep and may be susceptible to infection. With ongoing radiation, the skin condition and appearance often worsens. This trial aims to compare sorbolene cream which is the standard product that is recommended for use by patients at the Royal Adelaide Hospital with a lotion containing extract of Calendula officinalis (marigold flower), called Calendula lotion. Calendula is reported to have anti-inflammatory properties and may encourage skin healing. The hypothesis for the study is that Calendula lotion offers significant benefits compared to sorbolene when used for the prevention or treatment of RID. Who is it for? This study is open to women 18 years and over who have undergone prior lumpectomy or mastectomy and are due to undergo post-surgical radiotherapy for breast cancer using standard treatment pathways. Participants will need to provide informed consent, and not be undergoing any concurrent chemotherapy at the time of participation. Full exclusion criteria for this study can be found in the relevant section of this form. Trial details You will be randomised to receive either Calendula officinalis lotion (marigold extract 32%v/v) or Sorbolene lotion with 10% glycerine, which will be topically applied to skin twice a day every day of the week during radiotherapy treatment (typically a 5 week period) and for up tp 6 weeks. Participants will be instructed to apply lotion generously to entire irradiated skin using an amount approximately in size to a 20cent-50cent piece (dependent on physique).

The aim of the study is to identify patients with poor medication-taking behaviour and implement personalised interventions to improve medication-taking behaviour. We hope to learn about changes in medication-taking behaviour over time and to determine the degree to which improvements in this behaviour are sustained. We also want to learn if using the MAQ and Beliefs about Medicines Questionnaire - Specific was helpful to improve medication-taking behaviour. We hypothesise that: - Personalising interventions to patients known to have poor medication-taking behaviour will improve medication-taking behaviour at three months. - Improvements in medication-taking behaviour at three months will not be sustained at six months. - Medication-taking behaviour, and the reasons for poor medication-taking behaviour, will change over time in all groups studied.