ANZCTR search results

This is a registry of patients that have presented to Australasian hospitals with chest pain of possible cardiac origin. Multiple biomarkers will be stored for ongoing research. Participants will undergo risk evaluation by a means of a set series of questions. Participants will recieve a phone call at 45 days, 6 months and 1 year post discharge to record any major adverse cardiac event (MACE) they may have experienced at 30 days or 1 year.

This project is a pilot trial of a novel, non-robotic training device, the SMART Arm, to retrain upper limb function in stroke survivors with severe paresis. The aim of the trial is to determine the extent to which training of reaching using the SMART Arm with outcome triggered electrical stimulation, will lead to improvements in upper limb function for stroke survivors with severe upper limb paresis who are in the acute stage of recovery. In a pilot randomised control trial, 12 inpatients undertaking rehabilitation at The Townsville Hospital and who have had a first ever stroke within the previous three months will be recruited to the study. The participants will be randomly allocated to Intervention A or Intervention B groups. Participants allocated to the Intervention A will receive SMART Arm training WITH electrical stimulation and 30 minutes of usual care for 30 minutes per day, five days a week for four weeks. Participants allocated to Intervention B will receive 30 minutes of SMART Arm training WITHOUT electrical stimulation and 30 minutes of usual care, five days a week for four weeks. All training will be provided by Occupational Therapy staff of The Townsville Hospital rehabilitation unit. Pre-intervention and post-intervention assessment of arm impairment and activity will be undertaken by a blinded assessor. Study outcomes will be used to refine the training device and protocol and to estimate the required sample size for a follow-up RCT.

This is a randomized, open-label, multicenter, Phase 3 study comparing the efficacy and safety of eribulin with dacarbazine in subjects with advanced soft tissue sarcoma who have disease progression within 6 months prior to study enrolment following at least 2 standard systemic regimens for advanced soft tissue sarcoma one of which must have included an anthracycline, unless contraindicated.

Ear infection (otitis media) is a major problem amongst children living in remote Australian communities. Medical treatment often fails, and ear nose and throat surgeons are called upon to provide surgical care. This clinical trial will provide surgeons with evidence so that they can recommend the best possible operation for children living in desert and tropical regions, most of whom are indigenous, to improve hearing and reduce the prevalence of ear infection and discharging ears.

The study will measure the effect of 3 snack foods (2 types of peanuts one type of potato chips) on acute satiety and on subsequent satiety and energy intake over a 4 day period which may provide a mechanism for weight control. Hypothesis; It is hypothesised that consumption of high-oleic peanuts will improve satiety and reduce subsequent energy intake. It is anticipated that the protein and fibre content of high-oleic peanuts will increase satiety compared with consumption of low salt potato crisps of the same energy value

The aim of this study is to collect retrospective data on a consecutive case series to further support registry data and further elucidate the safety and efficacy of both femoral and tibial cementless components.

Strong, effective clinical leadership is critical in improving healthcare workforce retention and care quality, and reducing associated costs. Yet little evidence exists about the best ways to enable middle managers of aged care to develop clinical leadership skills, critical to the effective delivery of quality care. The trial is part of a larger study which has two aims: 1) to develop and promote evidence-based tools for improving leadership in the sector including a clinical leadership qualities framework (ACLQF) and a clinical and managerial leadership program in aged care (CLiAC); 2) and using a cluster randomised controlled design, to determine the feasibility and the effectiveness of CLiAC in improving workforce recruitment and retention and care safety and quality, which have not been previously researched in the aged care sector. Hypotheses include: the intervention group will have the following significant benefits over the non-intervention group. HP1 – enhanced work environment for aged care staff HP2 – improved care quality and safety for aged care recipients HP3 – reduced aged care staff turnover rates HP4 – reduced aged care staff absenteeism HP5 – improved aged care staff intention to stay and decreased intention to leave HP6 – reduced stress levels in aged care staff HP7 – increased job satisfaction for aged care staff HP8 – reduced cost of retaining and recruiting aged care staff, as well as cost of care HP9 – improved aged care managers’ knowledge and skills in leadership and management

This is a prospective observational study of the diagnostic utility of an accelerated diagnostic protocol using a central laboratory Troponin I in people presenting to the Emergency Deprtment with chest pain of probable caridac origin. A blood sample will be taken and tested on arrival and again at 2 hours. Participants will undergo risk evaluation by a means of a set series of questions. Patients will be followed-up to determine outcomes at 30 days and 1 year after presentation

This study seeks to test the acceptability and preliminary efficacy of a family focused, community-based physical activity program (FamilyFIT) conducted out of school hours, to increase the physical activity levels of primary school- aged children. It is hypothesized that the FamilyFIT program will be more effective then no program in increasing children’s physical levels. Objectively measured child and parent physical levels will be assessed by pedometers worn over 7 days; self-reported child (parent proxy) and adult physical activity levels, sedentary behaviour, parenting variables and aspects of home physical and social environment will be measured using items from validated instruments; and health-related assessments will be conducted using standardised protocols. Data will be collected for children and their parents at baseline (including demographic indicators) and post intervention for all measures.

The study has several aims: (1) to test whether cognitive processing therapy (CPT) is helpful after recent trauma; (2) to test that CPT is as good as the usual therapy delivered in the sexual assault service (treatment as usual, TAU); (3) to ensure that counsellors not previously trained in CPT can learn and deliver the therapy with the same results as previous studies that have used highly experienced and trained cognitive behavioural therapists. We predict that CPT will be useful in reducing posttraumatic stress, that it will be at a minimum as good as treatment as usual, and we hypothesise that CPT therapists will show results comparable to previous treatment outcome studies using CPT.