ANZCTR search results

A single-case ABAB design will assess salivary cortisol data and SIB frequency captured via video footage when the child travels in the morning from home to school by bus. Children will be exposed to two conditions. The Non-Music condition will see the child riding the school bus without listening to music. The Music condition will see the child listening to music whilst travelling to school by bus.

The aim of Study 2 is to explore the effect of Receptive Music Therapy (RMT) on salivary cortisol and SIB frequency from children with LFA and SIB within a randomised control trial laboratory setting, exposed to a Trier Social Stress Test (TSST). The randomised control trial will include a pre-test for salivary cortisol and SIBs, the random allocation of participants’ into no music and music groups whilst undergoing the TSST and a post-test for salivary cortisol and SIB frequency. Study 2 is designed to investigate the potential relationship between music and SIB as the mediated by level of arousal as illustrated in the 3-Stage Mediating Model. The laboratory environment used in this study provides the controls needed to establish support for the model prior to testing in a naturally stressful setting, the school bus.

This is a study to determine the safety and effectiveness of corneal collagen crosslinking in young persons aged 10-15 years and 11 months who have been diagnosed with progressive keratoconus. Keratoconus is a condition that causes distortion of the cornea (the clear, front window of the eye) that results in reduced vision. In the early stages, vision can be corrected with glasses or contact lenses, but in the more advanced stages a cornean transplant may be required. Collagen cross-linking is a treatment involving the use of riboflavin (vitamin B2) and ultraviolet light that has been shown to slow the progression of keratoconus in adults with a low risk of complications. We would like to study the safety and effectiveness of crosslinking in children.

This study aims to evaluate the feasibility and efficacy of two print-based interventions for increasing physical activity in Australian breast cancer survivors. Who is it for? You may be eligible to join this study if you are a woman aged 18 years or more who has previously been diagnosed with breast cancer at any time point. You must not be undergoing active treatment at the commencement of this study (i.e. chemotherapy, radiotherapy, surgery). Trial details Participants in this trial will be randomly (by chance) allocated to one of three groups. Participants in group one will be mailed three theory-based computer-tailored newsletters over a 12 week period. Each newsletter will provide advice and feedback unique to the individual that relates to key determinants of physical activity adoption and maintenance among breast cancer survivors. Participants in group two will receive a copy of a theory-based exercise guidebook developed specifically for promoting physical activity among breast cancer survivors. Participants in group three will be provided with brochure outlining the physical activity guidelines for Australian adults. Participants will be assessed at baseline, 4 months and 10 months to determine physical activity levels, quality of life, safety and individual expectations and barriers.

THis study is a pilot study to identify the magnitude of response of fish oil to power a larger randomised control trial. It is not intervention in that subjects have already been prescribed fish oil by their treating doctor and we are simply observing this

This is an open-label, randomized, sequential dose-ascending cross-over study in healthy male adults. There will be three cohorts of subjects enrolled in this study, starting with Cohort 1. Each cohort will receive a different dose level of CTP-298. Prior to the start of the first period for each Cohort, subjects in that Cohort will be randomised to one of two treatments sequences: Sequence A: CTP-298 to ATV/ritonavir OR Sequence B: ATV/ritonavir to CTP-298 A total of 12 subjects will be enrolled into each cohort, with 6 subjects randomised to each sequence group within each cohort.

The aim of the study is to determine changes in blood flow in the heart associated with low or high air pressures given with the nasal prong breathing support to the prematurely born infant. Research studies have shown that nasal CPAP can influence the way the blood flows in premature infants. We want to find out if the CPAP machine affects the function of the heart and the blood flow to the lungs. So that we can learn what is the most appropriate level of CPAP for infants with different types of lung disease that provides respiratory support with least affect on heart function.

We recently completed an RCT pilot study of an internet-based transdiagnostic treatment for anxiety disorders and for GAD, panic, social phobia and depression. Adherence throughout the program was roughly equivalent to that of our previous internet-based disorder-specific programs (76%), and post-treatment results finalised in January 2010 support the efficacy of this initiative. We are interested in further investigating the efficacy of internet-based treatments for a population of people suffering from GAD and/or depression.

Intravenous tissue plasmingen activator (tPA), is an approved therapy for ischaemic (clotting type) of stroke. A worrisome side effect of tPA is haemorrhagic transformation; ie bleeding into damaged brain tissue. This occurs in over 6% of stroke patients treated with tPA, and is associated with a mortality rate of approximately 50%. Minocycline, is an anti-biotic with properties that may protect brain tissue in stroke. Early studies confirm its safety in stroke patients. Animal experiments combining the two agents have shown reduction s in haemorrhage. The WAIMATSS study examines this combination in humans, with the aim being to reduce haemorrhage.

Obsessive-compulsive disorder (OCD) is a debilitating anxiety disorder. Given the strong demand for psychotherapeutic services, effective and reliable treatment for OCD is not always readily available. The aims of this research are to (1) develop an online self-help metacognitive therapy (MCT) programme for OCD, and (2) implement and evaluate the self-help MCT programme in an online controlled trial. A minimum of forty participants with symptoms of OCD will be recruited through the World Wide Web via snowballing throughout Australia. Participants will be randomly allocated to either control group or intervention group. Access to either the self-help MCT programme (intervention) or the progressive muscle relaxation training programme (control) through the website (the OCD-Doctor-Online) will then be granted. Participants will be required to complete each module of the programme before carrying onto the next. Participants will be administered several instruments measuring symptoms of OCD, depression, anxiety and stress, quality of life, and metacognitions at pre-test, post-test and at 6-week follow-up. If statistically significant reductions in OCD symptoms are found in this study it will justify the completion of further effectiveness and efficacy research and will potentially provide an important alternative treatment option for people diagnosed with OCD.