ANZCTR search results

This study will collect information from routine clinical care with the intention of evaluating the effect of Diphereline on the symptoms that are present in many men with prostate cancer, such as difficulty in postponing urination, how often they have a weak urinary stream and/or the need to push or strain to begin urination. These symptoms are referred to as lower urinary tract symptoms (LUTS).

This study aims to evaluate the effects of CPAP compared to oxygen on lung function in subjects as they recover from an episode of worsening heart failure. Subjects will be recruited on admission and have serial testing of their lung function early in their admission, just prior to discharge and 30 days following discharge. The effects of posture on lung function will also be evaluated.

This project is part of a research program funded by the NHMRC (No. 630560) to develop and evaluate Internet based transdiagnostic treatment programs for people with anxiety and depression. This preliminary project examines the efficacy of a treatment program for people with depression, social phobia and/or panic disorder (with or without agoraphobia) and/or GAD. The purpose of this study is to see if a brief internet-based intervention is effective at reducing levels fo anxiety and depression.

There has been a recent drive to perform hip replacements through smaller incisions. The question is, does this increase the risk of complications? The primary purpose was to assess whether a hip replaced through a smaller incision produced as good a result as when done through a standard incision. Our hypothesis was that it did, and was possibly more beneficial since fewer tissues were divided.

Knee osteoarthritis (OA), is a painful, chronic and progressive condition. Intense efforts are being directed towards finding the causes and effective treatments. But OA has more widespread consequences, including the loss of muscle mass and function in the affected legs. The loss of muscle is potentially both a consequence of OA, due to reduced limb use, but may also be a direct consequence of inflammatory mechanism set in motion by the knee inflammation. The aims of the current project are: (a) to compare genes which are involved in muscular protein synthesis and degradation in people with knee osteoarthritis (OA) and in asymptomatic older and young people. (b) To investigate the interaction between muscle breakdown and regeneration and impaired gait pattern in people with knee OA. This research is important, as preserving muscle mass is central to regaining effective limb use and reduce disease symptoms. Hypothesis (a) Older individuals with OA will have increased localisation of inflammatory immune cells within the skeletal muscle and increased activation of protein degradation pathways within the muscle cells, compared to asymptomatic older and young people. (b) In people with OA, there is an interaction between muscle protein and gene levels that will be associated with impaired gait measures.

This study looks at the effectiveness of early post-operative enteral (tube) feeding in people with advanced epithelial ovarian cancer. Who is it for? You can join this study if are a woman with primary ovarian, fallopian tube and peritoneal cancer who has undergone primary surgery to reduce the cancer. Trial details Participants will be divided into two groups. One group will receive standard postoperative care combined with early enteral feeding (feeding with a tube into the stomach). The other group will receive standard postoperative care only. Participants will be monitored for quality of life 6 weeks after surgery (at least a 10 point difference on the Functional Assessment of Cancer-General (FACT-G) quality of life instrument). The study aims to determine if early nutrition using a feeding tube has an impact on quality of life, length of hospital admission, recovery from surgery, complications from surgery, need for intravenous fluids after surgery, dosage of chemotherapy, nutritional status and ultimately a reduction in treatment costs.

The bacterium pneumococcus causes invasive disease, pneumonia and otitis media in young children. Seven-valent pneumococcal conjugate vaccine (PCV7) has been provided for Aboriginal and high risk children since 2001 and all Australian children since 2005. There are two new pneumococcal conjugate vaccines to be licensed in Australia by the end of 2010. These have 10 pneumococcal serotypes in common but one also offers protection from H. influenzae infection and the other has 3 additional pneumococcal serotypes. H. influenzae causes otitis media and non-bacteraemic pneumonia but is rarely cultured from blood cultures and thus is considered a less invasive pathogen. For Aboriginal children however, H. influenzae is the major pathogen associated with perforated tympanic membranes (ear drums) and it is thought to be an important cause of pneumonia. Invasive disease caused by the additional serotypes, particularly 19A, has increased in Australian non-indigenous population. Thus it is anticipated that most jurisdictions will choose to use the PCV13. However, because Indigenous children have much higher rates of infection due to H. influenzae than non-Indigenous children, Indigenous children may benefit from both vaccines. There are no studies that directly compare these two vaccines to determine overall clinical benefit. This Randomised Controlled Trial (RCT) will directly compare the two vaccines as well as an early 3+1 combination schedule, commencing at one months of age. Immunological, microbiological and clinical outcomes will be assessed.

this preliminary study aims to determine if yoga practice including adapted exercise, relaxation and meditation can reduce symptoms of BCRL and improve quality of life of women living with this condition.

The main aims of this study is to determine the impact of posture and meal volume on gastric emptying (GE), gut hormones, glycaemia, plasma insulin, haemodynamics, absorption, appetite, gastrointestinal (GI) symptoms after Roux-en-Y gastric bypass (RYGB).

This new research will investigate the prevalence of persistent cough, breathing difficulties and voice changes following H1N1 (swine flu) infection. We will also be investigating the role of cough risk factors including asthma, rhinitis (hayfever), reflux, Ace-Inhibitor use (for high blood pressure), obstructive sleep apnoea (a sleep disorder), voice changes, etc. As well as characteristics of persistent cough including length of cough, how severe the cough is, cough sensitivity, associated symptoms, breathing and voice changes. The current H1N1 influenza pandemic provides an opportunity to address many of the knowledge gaps in post viral cough. Our hypotheses are that there will be a prevalence of 10% of persistent cough and upper airway dysfunction following H1N1 infection. That upper airways disorder and heightened cough reflex sensitivity will be increased following H1N1 infection, and that voice changes will be more prevalent following H1N1 infection.