ANZCTR search results

The primary objective of the study is to examine the safety and efficacy of SATIVEX 'Registered Trademark (R)' in the inpatient management of cannabis withdrawal, in a double blinded randomised trial compared to placebo. Specifically, the study will compare withdrawal severity, detoxification completion and adverse events between the two conditions in an intention-to-treat analysis. Secondary objectives include 1-month post-withdrawal outcomes (including cannabis and other drug use and psychosocial outcomes), and to assess the relationship between the number, severity and duration of cannabis withdrawal symptoms and rates of continuous and point prevalence abstinence from cannabis, time to relapse, levels of cannabis use, and cannabis related problems at one month follow-up. The study will also explore the cognitive impact of withdrawing from cannabis, as well as the impact of SATIVEX on cognitive functioning, with an aim to assessing the real world safety profile of the drug ahead of larger outpatient studies. The study will also explore the pharmacokinetics and metabolites associated with SATIVEX (R) administration to develop a protocol for differentiating between SATIVEX(R) and illicit cannabis in blood or urine among those entering cannabis withdrawal treatment. This pharmacokinetic assay will prove useful for future large scale outpatient trials should the current trial prove successful. A final exploratory objective of the study is to determine whether there is evidence of an interaction with the efficacy of SATIVEX(R) and patient characteristics on admission (including demographics and cannabis and other use and psychosocial factors such as treatment expectancy) on reported severity of cannabis withdrawal and subsequent post-withdrawal outcomes (cannabis use, psychosocial outcomes, sleep disturbances and cannabis-related problems) to be fully tested in a larger community study.

Obesity is a global health epidemic increasing adverse health risks for sufferers. Lifestyle and diet are fundamental to prevention and treatment of obesity-related disorders and attention to the role of staple foods as part of total dietary intake is warranted. Wheat grain is a staple food in Western countries, providing energy, nutrients and fibre, and is commonly consumed as a breakfast cereal. When compared with highly refined cereals, wholegrain cereals are more nutritious beneficial in maintaining healthy weight, blood glucose, cholesterol levels, and reducing cardiovascular and diabetes risks. This study aims to evaluate the effectiveness of consuming 2 types of wholegrain wheat breakfast cereals in overweight and obesity, that have undergone different processing treatments and may differ in chemical composition.

Diastasis recti (also known as abdominal separation or DRAM) is a disorder defined as a separation of the rectus abdominis muscle into right and left halves. In pregnant or post-natal women, the defect is caused by the stretching of the rectus abdominis by the growing uterus and the increased hormones associated with pregnancy that cause flexibility in the body’s tissues. A clinically significant (larger) DRAM is defined as being greater than or equal to three fingers wide. Although these larger DRAMs are treated by physiotherapists at Southern Health, there is limited evidence into the physical/psychological problems suffered by women in association with a larger DRAM. The aim of this study is to investigate the incidence of back and pelvic pain, incontinence and body image in post-natal women, immediately post birth (incontinence only), six weeks (whether there is a clinically significant DRAM or other problems) and then six months after child birth. The incidence of any dysfunction as mentioned will be compared between women with either a) no DRAM (healthy age-matched women who have never been pregnant); b) a clinically insignificant DRAM (less than three fingers width) and c) a clinically significant DRAM (three fingers or greater wide). The study will also aim to determine the factors associated with back or pelvic pain, incontinence and body image in post-natal women. The findings of this study will inform the development of a randomized, controlled trial of physiotherapy intervention in women at risk of morbidity following DRAM.

This study aims to test if acupuncture is effective in treating hot flushes after the menopause.

This study evaluates an innovative supportive care intervention to improve the well-being of men diagnosed with prostate cancer. Who is it for? This study is for men who have recently been diagnosed with localised prostate cancer in Queensland. Trial details In this study participants are randomly (by chance) divided into two groups. One group will receive usual care, i.e. currently available resource and support materials. The other group will receive the Living with Prostate Cancer supportive care intervention. This includes the provision of self-management resources in both print and web-based form, as well as access to a study website where participants can interact in group discussions and forums. The intervention also includes group peer support phone calls for participants led by trained peer support volunteers and a specialist prostate cancer nurse counsellor. The duration of this intervention is 6 months. Participants will complete questionnaires at 3, 6 and 12 months after enrolling in the study to evaluate their psychological well-being and quality of life.

Young children with autism vary greatly in their social and communication skills, from non-verbal and difficult to engage, to using sentences and showing some interest in other people. For those children who are non-verbal and difficult to engage, there is minimal evidence to determine which interventions will successfully foster the social and communication development of these young children. Music therapists are trained to use music (which is by nature a non-verbal medium) to motivate, evoke and elicit responses and interactions from children with social and communication impairments such as autism. While the use of music therapy with children who have social and communication impairments has been widely described, the evidence has primarily taken the form of case studies. Within the Early Childhood sector generally, there is increasing awareness of the importance of a strong parent-child relationship in the successful development of early social and communication skills in both typically developing children and children with autism. Interventions that involve the parent and support the parent-child relationship have reported significant gains in the social and communication skills of children with autism. This project aims to determine to what degree the early social and communication skills of children with autism aged between 3 and 5 years are effected by participating in music therapy sessions with their parent (primary carer).

The purpose of the study is to identify, and quantify, the expression of fatty acid sensing molecules, including CD36, GPR119, GPR120 and GPR40, in human duodenal biopsies.

The study will look at whether Emotional Freedom Technique (EFT) is effective in helping individuals deal with food cravings.

investigators decided to decline the sponsorship offer.

Aim: This study aims to test the effectiveness of a childhood obesity prevention intervention delivered to first-time parents and focused on parenting skills which support the development of positive diet and Physical Activity (PA) behaviours, and reduced Sedentary Behaviours (SB) in infants. Hypotheses: In comparison to the control group infants, over the course of the intervention, the intervention group infants will: 1. Demonstrate greater increases in consumption of fruits and vegetables, and smaller increases in consumption of cordials, soft-drinks and juices and energy-dense snack foods 2. Demonstrate greater increases in time spent being physically active and smaller increases in time spent in sedentary behaviours, specifically Television (TV) viewing 3. Exhibit reduced incremental Body Mass Index (BMI) gain In comparison to the control group parents, the intervention group parents will demonstrate greater increases in: 4. The frequency with which they offer fruit and vegetables, water and milk (rather than cordials, soft-drinks and juices), and smaller increases in the frequency with which they offer energy-dense snack foods to their child 5. Knowledge regarding infant eating, physical activity and sedentary behaviours and greater development of positive attitudes/beliefs regarding their capacity to influence these behaviours 6. The adoption of desired feeding strategies, including the division of responsibility in feeding and in providing opportunities for modelling of healthy eating 7. The adoption of strategies, including modelling, for increasing opportunities for physical activity and reducing opportunities for sedentary behaviours