ANZCTR search results

The study intends to assess the human and financial cost benefits of providing aged care workers with enhanced working conditions including proactive physiotherapy care of joints and muscles separate from and together with direct psychlogical support in building stress resilience and indirectly through developing 'top down' improvement in psychosocial safety culture and enhanced team leadership. It is anticipated that both physiotherapeutic and psychological interventions alone will reduce the human and financlal cost of work related physical and emotional stress. We further anticipate that physical and psychological support combined will act synergistically to reduce injury (physical and emotional). Such reductions are anticipated to be demonstrable via objective measures of cost saving as well as self report of enhanced well being.

The study aims to establish whether taurocholic acid, administered as a suppository, can stimulate secretion of the gut peptides GLP-1, PYY, and oxyntomodulin, and suppress subsequent appetite and food intake. This information could be useful in designing treatments for type 2 diabetes and obesity.

PVP is a new procedure that may one day be able to replace TURP as the main treatment for men with benign prostate enlargement. There has only ever been one randomized controlled trial of PVP with TURP and this was using the now outdated 80W model. Recent advice from the UK National Institute for Health and Clinical Excellence has stated that PVP should only be used in the context of randomized controlled trials. We intend to assess whether the procedure has long term benefits for patients and whether it is cost efective for health providers.

The purose of this study is to understand how well Oxycodone in combination with tocopheryl phosphate mix (TPM), is absorbed through the skin and into the bloodstream, with the use of a patch.

This study seeks to determine whether the Girls on the Go program is able to improve the self esteem of young girls and reduce their risk of developing disorders related to body image. It is hypothesised that the program will improve participants self esteem and reduce their risk of developing disorders related to body image.

The purpose of this study is to evaluate the effectiveness of probiotics in reducing the recurrancce of urinary tract infection (UTI) in people with spinal cord injury and other neurological disorders. It is hypothesised that probiotics reduce the incidence of UTI.

We have developed a web-based decision aid (‘My Health Check’) for 30 to 69 year olds, based on both evidence and personal preferences. Users are asked to complete a questionnaire which includes questions about their age, gender, and health behaviours relevant to My Health Check (up to 10 depending on their age and gender). They are also asked to rate how difficult they would find each health-check activity. Then they are asked to indicate how important each of four attributes (factors determined by focus groups as important when making decisions about preventive health activities) are to them. My health check then displays a list of health behaviours, ranked from greatest potential for gain to least potential for gain. This study will determine whether or not users of My Health Check are more likely to adopt health preventive behaviours than people who are just shown the standard information on the web.

The current study is a randomised controlled trial aiming to test the preliminary efficacy of an internet-based intervention for people with depressive symptoms. There will be 2 groups of randomly allocated participants who will be followed up after 3 months of an online program: 1. Brief Intervention Group – will be an active control condition providing a minimum, ethically feasible treatment including Psychoeducation on depression, a Personal Diary for recording mood, and tools for detecting and planning for triggers and early warning signs of depression. 2. 5 Module Treatment Group – will include the components of the Brief Intervention Group as well as specific modules involving Mindfulness Meditation, Social support/relationships, Problem Solving and CBT strategies, Pleasant Activity Scheduling, and reviewing personal changes and making future goals. Primary predictions are that the 5 Module Treatment group will have superior depression outcomes at 3 months compared to the Brief Intervention group.

The primary purpose of the study is to test whether intra-oral myofascial therapy for chronic myogenous temporomandibular disorder is more effective than education and self care in the short term

Boys with Duchenne muscular dystrophy (DMD) have an increased risk of long bone and vertebral fracture due to reduced bone mass (osteopenia). In DMD, osteopenia is due to both reduced mobility and glucocorticoid use. There is no recognised treatment for osteopenia in DMD. Bisphosphonates are a class of drug which act primarily by decreasing the activity of the bone resorbing cells, the osteoclast. In children with osteogenesis imperfecta (brittle bone disease) bisphosphonates have been shown to improve bone strength and increase bone density (areal Bone Mineral Density (aBMD)) through a combination of increased cortical thickness and trabecular number. Bisphosphonates alter the course of corticosteroid induced bone loss and largely prevent this complication in the adult population. It is more difficult to provide such evidence in a paediatric population where linear growth and puberty both rapidly alter skeletal size and make interpretation of bone density more difficult. With techniques of volumetric bone density (BMAD) calculation available, more accurate data can now be observed. Study significance This study is powered to provide definitive data on the utility of 3-6 monthly intravenous zoledronic acid to improve bone density in boys with DMD. Results from this study will be used to develop a study to assess fracture reduction in this population. This in turn would have far reaching consequences in terms of potential reduction in morbidity, hospitalization and immobilization of affected boys.