ANZCTR search results

People with kidney failure often develop a condition called ‘uraemic neuropathy’, where the function of the nerves in the hands and feet is impaired. These changes cause weakness, numbness and tingling. Our studies have shown that high levels of potassium in the bloodstream may cause uraemic neuropathy. The purpose of this study is to investigate whether reducing the amount of potassium in a patient’s diet may help prevent neuropathy.

A randomised controlled trial is required to compare Computer assisted surgery with Patient Matched Instrumentation to see which provides best alignment with minimal operating time.

The aim of this project is to determine whether therapy using the Nintendo Wii Fit computer game is as effective as practise of more traditional therapy activities for older people in hospital.

The aim of this study is to investigate the benefits of a 12-week intervention involving 10 weekly treatment sessions delivered by a physiotherapist on a one-to-one basis. The study will examine the effectiveness of a combined exercise and Cognitive Behavioural Therapy (CBT) intervention compared to each intervention (CBT or Exercise) alone. Hypothesis: A 12-week intervention that combines exercise with CBT will be more effective in improving pain (visual analogue scale) and physical function (WOMAC subscale) than either a 12-week intervention of exercise alone or CBT alone in individuals with painful radiographic knee OA.

This study is a pilot study to take place prior to a larger Randomised Controlled Trial (RCT) "Garlic and Candida: An Exploratory Study." The RCT proposes to investigate the biological plausibility of oral garlic reducing recurrences of vaginal thrush by reducing the vaginal colonisation of Candida albicans. The RCT will involve women taking either oral daily garlic tablets or placebo, keeping a daily diary, and self collecting daily vaginal swabs and posting them to the laboratory during the second half of their menstrual cycle. This pilot study will evaluate the methodology by assessing the tolerability of the garlic tablets, the postage of the swabs, and the daily diary. It will also include a validation study on postage of vaginal swabs.

A double blind trial designed to assess the pain associated with the injection of lignocaine (Xylocaine) and mepivacaine (Scandonest) two local anaesthetics commonly used in podiatric practice. So, is mepiviacaine a less painful anaesthetic to be injected into a toe than lignocaine. Subjects will be selected from the University of Newcastle Podiatry Clinic, the subjects have been selected would require nail surgery of both big toes. The practitioner and the subject will be blinded to which anaesthetic has been used in each of the toes. After each injection the subject will be asked to complete a visual analog pain scale.

This study aims to evaluate the changes in lung function caused by the use of continuous positive airway pressure compared to standard therapy in patients who have been diagnosed with a worsening of their heart failure. Continuous positive airway pressure is a way of delivering pressure to the airway through a mask connected to a machine. It is used routinely in the treatment of heart failure to improve outcomes but how it works on the lungs is not well understood. By using a method of measuring lung function that can be done whilst on continuous positive airway pressure and that requires minimal active patient co-operation this trial hopes to provide insight into the mechanisms of this treatment.

The study aimed to help inform how best to deliver nutrition services to older adults identified at risk of malnutrition, through the provision of frequent, individual nutrition support by a dietitian from the Emergency Department, compared with the provision of the current service to community-dwelling older adults identified as at risk of malnutrition. This investigation aims to assess the impact of the service provided on the nutritional status and other outcomes including frail mechanical falls, hospital admission and quality of life.

The primary purpose of the study is to assess the safety and tolerability of one oral dose of a human rotavirus vaccine, RV3-BB, in three successive age groups starting with adult men aged 18-50 years, progressing to children aged 3-8 years and then infants 6-8 weeks. Assessing rotavirus immunity, via serologic markers and faecal extracts, is a secondary objective.

The purpose of this study is to confirm that gluten-containing foods causes abdominal symptoms and fatigue in people who do not have coeliac disease and to investigate if these individuals can tolerate a low-dose of gluten.