ANZCTR search results

This is a trial aiming to assess how effective a drug called clonidine is in sedating children in intensive care. Children are normally kept asleep with morphine and midazolam, both sedative drugs with side effects like tolerance and withdrawl. Clonidine acts as a sparing agent, reducing the need for these drugs, and reducing the chance of side effects. This trial aims to show that by using clonidine, we allow a significant reduction in use of morphine and midazolam, and therefore a reduction in side effects. By showing this, we aim to encorporate Clonidine into normal sedation practice, improving our safe practice.

The purpose of this study is to determine whether or not the reduction of Atrial Fibrillation (AF) by the AF Suppression algorithm halts or reverses the electrical remodeling that has already begun in AF Patients

The planned study targets patients with end stage kidney disease who choose peritoneal dialysis for maintenance therapy. Current practice at the Royal Brisbane and Women's Hospital is to wait four weeks after a Teckhoff catheter is placed before starting peritoneal dialysis . The literature lacks evidence of the optimal interval between peritoneal catheter insertion and start up of dialysis. Consequently practice varies. They too support delayed use but do not test different delay intervals and can not tell us the optimal time. A few recent studies reported a very low leak incidence after using catheter 1 week post insertion , attributed to a tight catheter securing. Any delay in starting PD results in temporary haemodialysis in patients who require immediate dailysis. Temporary haemodialysis requires a central venous access with attendant risk of complications. Temporary haemodialysis is more expensive than peritoneal dialysis . Therefore guidelines bodies, such as CARI (Caring for Australasians with Renal Impairment,), European Dialysis and Transplant Association-European Renal Association and International Society for Peritoneal Dialysis suggest a two week delay. They can can only publish suggestions based on the weak body of evidence, or lack thereof. CARI suggests randomised control trial as there is insufficient evidence for this to be a “guideline’’. The primary objective of this study is to determine the safest and shortest time interval between surgical placement of a Tenckhoff catheter and starting dialysis. The hypothesis is that there is no difference in complication rates between one, two and four week time intervals. If equivalence is proven between one, two and four week time intervals, we could justifiably change practice. Benefits for future patients include shorter exposure to haemodialysis treatments and their complications and shorter duration of haemodialysis catheter placement and its complications. If the results show more complications in the one or two week time interval groups, then we would encourage re-visiting the guidelines. catheter placement and its complications.

The purpose of the study is to examine if access and provision of early Speech Pathology intervention for ventilated tracheostomy patients in intensive care improves their time to communicate verbally, increases their quality of life and satisfaction and is safe.

To follow a patient’s journey via interviews through the hospital system from presentation to ED through to discharge from the hospital service where RITH has been involved in the patient’s rehabilitation. This will provide the RITH team with: an understanding of exactly where patient and carer experience can be improved; 'mobilising narratives' that will help inspire RITH to improve the service they provide; a teaching tool to provide to referrers regarding the benefits of hospital substitution and choosing the right patient cohort.

Study hypothesis is that mesenchymal cells are safe and will be effective in treating steroid refractory graft versus host disease. Trial subjects will receive 2 X 10 E6/kg mesenchymal cells weekly for 2 weeks, are then reassessed weekly. If inadequate response may receive two further doses at weekly intervals. May be retreated if they subsequently relapse

The study is designed to examine the hypothesis that increasing the level of specific immunity to the proteins of hepatitis C virus will result in a reduction in the viral load and/or clearance of the virus.

The objective of the study is to determine how effective imiquimod cream is in curing lentigo maligna and whether it is a possible replacement for surgical excison as the primary treatment.

The primary objective is to determine whether or not a rehabilitation physician appointment can help with return to work (full or suitable duties) and usual activities after a motor vehicle accident..

Primary Aim: To assess the effect of recombinant LH (rLH) use in patients undergoing IVF/ICSI who experience a 50% or more reduction in serum LH concentrations from the early to mid follicular phase. IVFAustralia has performed a retrospective pilot cohort study, which in 701 cycles of IVF/ICSI revealed that a reduction 50% or greater from early to mid-follicular LH concentrations resulted in significant reduction in live-birth rate (Lahoud et. al., 2006). Research Design:Prospective Randomised Controlled Trial Study population: Patients undergoing IVF/ICSI treatment at IVFAusralia. Intervention: The treatment group will receive 75 IU of rLH (Luveris) from day 7 of FSH administration until and including the day of HCG administration. Primary outcome: Clinical Pregnancy Rate