ANZCTR search results

Recent evidence shows an ethnic variability in tolerance of anticancer drugs between Asian and Caucasian breast cancer patients. Pharmacogenetic differences in drug metabolising enzymes have been proposed as the cause of these differences, however they have not been associated with altered cytotoxic drug pharmacokinetics (PK). Other possible explanations include differences in dietary/concomitant medicine intake and inflammatory status. The aim of this study was to investigate inter-ethnic differences in cytotoxic drug metabolism, inflammatory/nutritional status, genotype and outcomes between Asian and Caucasian breast cancer patients.

To determine if low level laser stimulation of acupunctrure points in a course of 8 weekly trearments is effective in relieving pain and disability in patients with chronic low back pain .

The purpose of the study is to 1/ Identify the population of patients selected by physicians to be implanted with a SJM ICD featuring the ST segment monitoring feature. 2/ Document the incidence of ST segment shifts, symptomatic or not, in that population and their possible relationships with clinical events. 3/ Document the change in patient management related to availability of device diagnostics.

Healthy reproductive function is essential for conception and pregnancy. We have discovered that male seminal fluid can influence the female reproductive system after coitus. This project will define the actions of seminal fluid in the cervix and uterus, and the impact on fertility and defence against sexually transmitted infection. The findings will provide new insight on how men contribute to reproductive health in women, and lead to improved treatments for infertility and miscarriage. On the basis of our extensive studies on the female response to seminal fluid in animal models, and observations to date in human tissues, we hypothesise that in women, male seminal fluid interacts with epithelial cells lining the cervix and endometrium to activate a similar but distinct inflammatory cytokine response in both tissues.

The aim of the study is to evaluate the ability of various physiological and inflammatory markers to predict changes in asthma control following changes in the dose of combination therapy. The direction and magnitude of the dose changes are determined for each patient by their baseline level of asthma control. If the baseline variables, either alone or in combination, can predict future benefit or risk from change in treatment then the study will provide new insights into the clinical management of asthma.

Chest pain is one of the most common reasons for presentation to Australian emergency departments. Despite this little is known about the safety of our current practice, which often involves patients spending many hours in an Emergency department awaiting repeated blood tests and electrocardiograms. Recent introduction of a latest generation super-sensistive troponin to our laboratory combined with an interest in an accelerated 'multimarker stratgey' already in widespread use throughout the UK and the USA (that back in 2006 was ranked as having the same level of evidence as our current practice by the American college of Emergency Physicians) and a desire to increase efficiency we have redesigned the way our department manages patients presenting with non-traumatic chest pain that allows us to confidently discharge patients as soon as 4 hours after the onset of their symptoms. This trial is intended to compare the efficacy and safety of this new process, when compared to the old process.

This study will investigate whether two interventions; omega-3 fatty acids supplements (fish oil) and the antidepressant, sertraline, are able to reduce or prevent depression and cognitive change. The study will run over 12 months and participants will be randomly allocated to one of the interventions or to a placebo condition. Participants will be assessed at different time points by telephone interviews, self report surveys, medical examinations and brief psychological assessments. These assessments will look at the effectiveness of the two interventions in reducing symptoms of depression and/or new cases of depression and reducing cognitive decline (e.g. changes in memory, concentration and thinking) associated with ageing. Additionally, because depression is believed to have a biological basis and because both these interventions influence brain activity, participants will also be invited to have three brain scans over the time of the study. We hope to track the effects of fish oil and sertraline on the brain changes associated with the normal ageing.

To determine the efficacy of iCBT in anxiety and depression

Circulating testosterone levels in young healthy women exceed those of oestrogen and by the time women reach their 40s, their blood testosterone levels are about half those of women in their 20s. Restoration of testosterone levels in postmenopausal women to those of younger women improves several aspects of cognitive function using conventional tests of cognitive performance. More recently, in a pilot study of postmenopausal women given transdermal testosterone over a period of 26 weeks we observed improved verbal and visual learning and memory using highly sensitive measures of cognitive performance. The aim of this study is to use these sensitive measures of cognitive function, which can detect subtle changes in cognitive performance in well older individuals, in a randomised placebo-controlled trial to determine whether restoration of blood testosterone levels in older women to those of premenopausal women over 26 weeks enhances cognitive performance when compared with placebo therapy.