ANZCTR search results

After anaesthesia children frquently become irritable and distressed. This is termed Emergence Delirium (ED). Sometimes this can lead to intravenous lines and surgical drains becoming dislodged. The child rarely remember this period and it rarely has any longterm consequences. A number of studies have suggested that a commonly used anaesthetic drug called propofol can be used to reduce the chance of this happening. We plan to administer a dose of propofol at the end of an anaesthetic to see whether it will reduce the rate of ED.

This study will compare the new insulin pump with low glucose suspend feature with current pump therapy to see if there is any change in rates of hypoglycaemia.

The primary purpose of the study is to provide investigators with the information necessary to carry out a clinical evaluation of the SJM Epic Valve. In doing so the study will collect information to establish the adverse effect rates, clinical status as indicated by NYHA functional classification and hemodynamic performance.

To obtain “real-world” clinical outcomes of neuromodulation in patients with St. Jude Medical Neuromodulation Division devices. An observational registry is defined as non-interventional research that involves the collection of scientifically valuable information for the purpose of answering important research questions. The term 'non-interventional' means that the healthcare provider's decisions regarding the proper treatment and care of the patient are made in the course of normal clinical practice.

The primary objective of the study is to evaluate the safety and effectiveness of the AqueSys Implant for the treatment of ocular hypertension and open angle glaucoma.

Helicobacter pylori (H. pylori) infection is a common stomach infection affecting ~50 % of people worldwide. In most cases, patients have no symptoms. H. pylori infection does induce immune responses, however they are not protective. For these reasons Ondek Pty Ltd is developing H. pylori as a live bacterial delivery system for vaccines and other therapeutic agents. The aim of this study is to find strains of Helicobacter pylori which can be safely used as a vehicle for the delivery of vaccines such as that used to treat Influenza in humans. Here we would like to assess the suitability of H. pylori strains as a live bacterial vector, and identify clinical isolates with a safe profile in humans.

This study will randomly allocate patients with PTSD to either (a) imaginal exposure, (b) in vivo exposure, (c) combined imaginal and in vivo exposure, or (d) combined imaginal, in vivo exposure, and cognitive restructuring.

Avena sativa (oats), in its various forms and extracts, has been traditionally known for its physical and psychological fortifying properties. Proposed beneficial effects include: reduced risk of heart disease, raised energy levels, increased ability to cope with stress, reduced anxiety and depression, and increased physical and cognitive performance. The mechanism of effect is currently unknown. However, it has been suggested that some ingredient(s) found in green oats have clinically significant inhibitory effects on monoamine oxidase B (MAO-B) and phosphodiesterase 4 (PDE4), effects which may improve cerebral vasodilatation. As enhancement of cerebral blood flow by vasoactive nutrients has been hypothesised to improve cognitive function, this may be the mechanism by which oat extract could improve cognitive performance and stress response. The aim of this study is to examine the effect of daily consumption of Neuravena for 12 weeks on the ability to cope with stressful cognitive tasks, cognitive performance and on psychological well-being (mood) and whether these effects are mediated by changes in cerebral blood flow.

Primary Hypothesis: Patients selected with significant penumbral mismatch 4.5-9 hours post onset ischemic stroke given intravenous tPA will have improved clinical outcomes compared to those who have been given placebo. Secondary Hypotheses: 1. An increased risk of post-stroke depression will be predicted by biological markers related to stress and 5-HTTLPR genotype. 2. Increased risk of post-stroke depression will be predicted by an increase in proinflammatory biomarkers (i.e. cytokines and C-reactive protein) and APOE genotype, particularly in those who do not receive thrombolysis. 3. Diet and lifestyle factors, involving i) increase in lipid concentrations and decrease in vitamin B12 concentrations; ii) low activity levels; and iii) reduced participation in daily activities; will be associated with the presence and severity of depressive symptoms, recurrent stroke and functional outcome.

The objective of this study is to determine whether ingested acetate which has been chemically attached to starch is released in the gastrointestinal tract of healthy humans. This will be determined by feeding known amounts of a high amylose maize starch to volunteers and measuring acetate levels in faeces, microbial population diversity, bowel health parameters, and blood electrolyte levels. This study will provide information about the effects and acceptability of the acetylated starch in healthy individuals and will provide the basis for clinical studies in patients with diarrhoeal disease.