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The primary purpose of this study is to evaluate the safety and effectiveness of a unilateral application of bronchoscopic thermal vapour ablation for improvement in function and demonstrate reduction of lung volume in patients diagnosed with heterogeneous upper lobe emphysema.

The home and family food environment are among the most influential factors in shaping children’s dietary habits. The aim of the study is to assess the effectiveness of a telephone based intervention in supporting parents of children aged 3-5 years to modify their home and family food environment to increase their child’s fruit and vegetable consumption.

Traditionally, therapists treat clients in the same room. However, many people do not have direct access to such services. Recent advances in computer technology have made it possible to see and hear someone who is not in the same room. This form of contact is called videoconferencing. Hence, the purpose of this research is to study how successful treatment is via this medium.

Exposure to asbestos can cause diseases of the lung such as asbestosis, mesothelioma and other lung cancers. Many of the changes in the lung following exposure to asbestos fibres are probably caused by ongoing inflammation and oxidation. N-acetylcysteine (NAC) is an anti-inflammatory and antioxidant drug that has been used for many years in patients with other lung disease. The drug seems to have beneficial effects on symptoms in patients with lung disease. Due to its anti-oxidant proerties we hypothesised that NAC would help to prevent oxidant and inflammatory changes in the lungs of people that have been exposed to asbestos. The aim of this study, therefore, is to investigate if NAC can prevent lung inflammation in people who have been exposed to asbestos and are at risk of asbestos related lung disease.

The study is a randomised controlled trial (with a wait- list control group) of the six month, group-based go for your Life diabetes prevention program, the Healthy Living Course. Outcome variables included the degree to which participation in the program led to changes in modifiable risk factors including behaviour (physical exercise, dietary intake), diabetes knowledge, body weight, glucose metabolism (measured using an Oral Glucose Tolerance Test (OGTT), triglyceride and cholesterol metabolism, cognitive variables (self efficacy, motivation), and mood (depression, anxiety, and positive affect). Volunteers (N=307) with pre-diabetes were assigned to an intervention or wait control group in the ratio of approximately 2:1. Biochemical, anthropometric, behavioural, cognitive and mood variables were tested at baseline and then again either at the end of the intervention or the wait period.

Currently, melanoma is the fifth most common cancer diagnosed in men and the seventh most common cancer diagnosed in women.Advanced melanoma has a very poor prognosis.For a vast majority of subjects with malignant melanoma, there are no effective therapies.Therefore, the development of effective therapies for this subject population remains a priority in oncology.In a limited study in melanomas, increased cyclin D1 protein expression, as was observed in 33% cases.P276-00 is a novel potent small molecule flavone derived Cyclin dependent kinase (Cdk) Cdk 4-D1, Cdk1-B and Cdk9-T inhibitor.P276-00 demonstrated significant and selective antiproliferative effect against melanoma cell lines.

To observe on eye performance of three marketed contact lenses.

Despite the recognised association between salt intake and blood pressure, there have been no studies documenting salt consumption in patients with type 2 diabetes. We hypothesized that the majority of patients with type 2 diabetes may not comply with the recommended guidelines for sodium intake.

The long-term presence of physical and psychosocial symptoms following breast cancer treatment is well established. However, Queensland is a geographically dispersed state, where many women with breast cancer live in rural and remote areas with limited support resources. Queensland-based research highlights that these women are more likely to have more extensive surgeries, and experience poorer quality of life and higher unmet needs. Exercise is one strategy with a large evidence base supporting its effectiveness in reducing symptoms and improving quality of life (QoL) among women following breast cancer. However, the majority of studies have been conducted overseas, and with women in urban areas. This pilot study will evaluate the feasibility of a telephone-delivered exercise-based rehabilitation support program for women newly diagnosed with breast cancer living in regional, rural and remote areas of Queensland, Australia. Feasibility and effect size data from the pilot study will be used to refine the intervention and to inform a subsequent application for a fully powered randomized controlled trial. This study forms an arm of a larger study that is currently being undertaken (ACTRN12606000233527) with an urban sample of women who have received breast cancer treatment via Brisbane-based hospitals (Royal Brisbane & Women’s Hospital, Mater Hospital and Wesley Hospital).

Patient adverse events occur in up to 17% of all hospital admissions. One contributing factor is the failure to recognise and appropriately manage deteriorating patients on the general ward. The ability to detect early deterioration allows early appropriate intervention and reduces unplanned admissions to intensive care unit (ICU) and unexpected deaths. In this study, a new ward observation chart will be installed into four wards (2 at The Canberra Hospital [TCH], 2 at Calvary Hospital [CH]), which will allow the recording of a modified early warning score. High scores will automatically trigger the nurse at the bedside to call an appropriately qualified medical practitioner for a timely review of the patient and initiate earlier management. We will review the morbidity and mortality of patients before and after this intervention