ANZCTR search results

The aim of this study is to determine how adrenaline affects the absorption of levobupivacaine in children having caudal anaesthesia for sub-umbilical surgery. Our study hypothesis is that the absorption of levobupivacaine will be affected when administered in conjunction with adrenaline via the caudal route.

The primary purpse of the study is to determine if blowing carbon dioxide gas into the chest cavity during a cardiac surgery operation involving the heart valves protects against the decrease in mental function that occurs following these operations.

In this project a new intervention for the vocational rehabilitation of chronic compensated musculoskeletal disorders will be developed. The intervention will add self-management training to usual care for injured workers who have transitioned from the acute to chronic stage of their musculoskeletal condition. Study participants will be recruited through one of the industry partners, Health Services Australia, a national provider of occupational health services and vocational rehabilitation. The participants who meet the inclusion criteria will be recruited from clinics in Brisbane, Canberra, Melbourne, Tasmania or Adelaide. Participants will be randomised into two study arms: the new model for management or a control group who will receive usual care. Acceptability, effectiveness (job readiness, health efficacy and pain) and the cost-effectiveness and cost-benefit of the new model compared to usual care will be assessed using tools which have been pre-tested with this target group. Aims: 1. To develop and document, in care protocols, an intervention which adds self-management to vocational rehabilitation for patients with chronic compensated musculoskeletal disorders. 2. To test the acceptability of the intervention to patients, their vocational rehabilitation providers’, policy makers and regulators through qualitative research with representatives from each group. 3. To test the effectiveness of the intervention by comparing readiness to return-to-work, health efficacy and pain in a group of patients who receive the intervention and a control group who receive usual care (single blind randomised controlled trial). 4. To assess the cost-effectiveness, and cost-benefit of the intervention. Hypotheses: 1. That adding self management to vocational rehabilitation will be acceptable to patients, health-care providers, policy makers and regulators. 2. The proportion of workers who are classified as ready to return-to-work based on a validated scale (the ‘Prepared for action - Self-evaluative or Maintenance-Uncertain or Maintenance-Uncertain category’) will be significantly different for those participating in the self-management program. This will be achieved through an improvement in their health efficacy (as defined by the heiQ questionnaire). 3. Adding self-management to active treatment and vocational rehabilitation will be worthwhile from an efficiency perspective, i.e. the productivity gains from adding the program shall be greater in dollar value than the societal costs of the program.

This study has been designed to determine the effectiveness of a routine anaesthetic practice at the Royal Children's Hospital (RCH) in Melbourne. At this institution, we pour local anaesthetic into the pharynx (throat) of children having general anaesthesia with a tracheal tube (breathing tube) in the hope that the larynx will become partially anaesthetised in order to reduce adverse events during anaesthesia such as coughing, laryngospasm (the vocal cords clamping together), oxygen levels dropping in the patient's blood, or slowing of heart rate.

Many people take a number of medications for a variety of clinical conditions. While individual medications may relieve the symptoms or treat the condition for which they were prescribed, they may interact with other medications prescribed or have exaggerated effects with other changes such as weight loss. In palliative care, many are on the medications which they have been taking for many years and new medications are added for symptom control. This situation may be compounded if more than one doctor is writing prescriptions for medications. The aim of this pilot study is to identify if there are events that a person may find troublesome that could be related to how multiple medications are prescribed.

We invite you to participate in a research project which we believe is of potential importance in identifying the significance of vitamin D deficiency in patients with obesity and diabetes. Vitamin D deficiency has been shown to poorly affect cardiovascular health, and we hope to investigate whether vitamin D supplementation will improve markers associated with cardiovascular health. We hope that the findings of this study will help us better manage this condition in future.

This study will attempt to identify potential clinical, histopathological and other novel predictors of survival outcomes in patients with malignant mesothelioma. Who is it for? You can join this study if you have a newly diagnosed malignant mesothelioma affecting your lung lining (pleura). Trial details: Participants with malignant pleural mesothelioma in all stages of disease will be recruited. Participants will be treated with the current standard medical therapy by the treating physician without study specific intervention. Participants will be consented for collection of their tumour tissue, blood samples and answering some questionnaires at baseline and subsequent follow ups.

The primary purpose of this study is to identify problems and obstacles to conducting a larger randmoised controlled trial that investigates the effect of weekend physiotherapy (in addition to weekday) compared to weekday only physiotherapy for inpatient rehabilitation patients. It is hypothesised that patients who receive the weekend therapy may achieve their physical goals earlier and have a shorter hospital length of stay.

The purpose of this study is to determine how safe and how well the human body tolerates transdermally delivered oxycodone combined with our patented technology (gel) in different patch forms. We would also like to see how much of the final product reaches the bloodstream after transdermal application.

The aims of this study are to show that patients with hypertension and abnormal left ventricular (LV) filling (but without coronary artery disease) may have their echocardiographic and biochemical markers of myocardial fibrosis and diastolic function improved by treatment with spironolactone, an aldosterone antagonist with anti-fibrotic properties.