ANZCTR search results

Continuous haemofiltration is performed in ICU to support patients with acute renal failure. The patient’s blood is pumped through a haemofilter where uraemic toxins are removed and then it is returned to the circulation. This is a continuous process that necessitates safe reliable large bore access to the circulation. The vascular access catheters are inserted percutaneously, usually into the femoral or internal jugular veins. There are number of commercial vascular access catheters available, but the industry standard for the past 10 years has been Bard Niagra, Bard Access Systems Inc. Utah, USA. This has large diameter channels, allowing high blood flows, but it occasionally can be difficult to insert. A new product, the Gambro Dolphin Protect, Gambro Lund Sweden, vascular access catheter has become available. It has a similar wide bore channels, but the shape of the cannula might make insertion easier and the catheter is impregnated with an antibacterial material that might reduce the rate of infection. These claimed advantages are only valuable if its basic function matches that of the industry standard. The aim of this study is to compare the two vascular access devices in a randomised controlled trial. The primary outcome measure will be trans-access resistance, a mathematically derived measure of the ease of blood flow through the catheter. Secondary outcome measures will be time to insert (in minutes) and ease of insertion measured on a visual analogue scale, presence of colonisation of the catheter at the time of removal (all tips will be sent for culture), presence of skin erythema at insertion site at time of removal, and haemofilter life (time to failure of haemofilters connected via the test cannula).

This project aims to evaluate individual care packages compared with usual care for complex and unstable symptom management and high care needs patients wishing to return home earlier from hospital or Palliative Care units AND for those requiring high level End of Life Care who wish to remain at home. This may include patients who have cancer or non-cancer diagnoses. Care packages at home could include nursing, domestic support, and equipment provision as well as more expeditious access to Specialist Palliative Care multidisciplinary team (MDT) services and General Practitioners. The evaluation project will explore the net incremental effect on patients and caregivers outcomes and associated net incremental costs relative to usual care.

To examine the safety and tolerability of Everolimus in combination with 5-azacitidine in Acute Myeloid Leukaemia.

Adolescents with diabetes display limited joint mobility. Because of the association with high pressures under the feet, poor sensation and foot ulceration with disease progression, limited joint mobility assessment is a standard procedure in diabetic foot care. Clinical interventions to reduce high pressures under the feet include orthoses, footwear and surgical correction. While stretching has been reported to improve ankle joint range of motion in the general population, limited evidence is available for individuals with diabetes. The evidence for calf stretching in adolescents where prevention of contractures and high plantar pressures in the early stages of disease may be most beneficial have not been investigated. This study will use a randomised control study to investigate the efficacy of stretching on the ankle and big toe joints to reduce high pressures under the feet and contractures of the ankle and foot joints.

The overall aims of the project are to design, implement and evaluate an educational campaign, known as MindWise to help raise mental health literacy in higher education students and staff. Data will be collected on mental health problems (anxiety, depression and alcohol misuse), knowledge of and beliefs about mental health problems, stigmatizing attitudes, self-help and help-seeking behaviours at baseline, at the end of the 2010 academic year and the end of the 2011 academic year. Data will be collected via telephone interviews carried out by the Social Research Centre.

Selected patients with signs of pudendal neuralia and low back pain treated with physiotherapy consisting of mobilisation and exercises directed to the lumbar pelvic region.

This study investigates the effects of branched chain amino acids and/or Synbiotics, a mixture of probiotics and prebiotics, on the level of hepatic encephalopthy in patients with cirrhosis using using computerised psychometric test and trail making test It also investigates the effects of branched chain amino acids and/or Synbiotics, a mixture of probiotics and prebiotics, on inflammatory process, quality of life, frequency and duration of hospitalisation, food intake and body composition.

An Early Intervention Program which targets preschool aged children who are at a high risk of developing anxiety. Efficacy of the program will determine whether prevention steps in the early years have a part to play in reducing current symptoms and also associated risk.

The aim of the present study is to examine the efficacy of a group modified cognitive behavioural therapy (CBT) intervention on reducing anxiety and internalizing disorders in adolescents with high functioning autism spectrum disorder. In addition to a longitudinal follow-up, this study seeks to determine the impact this treatment has on family quality of life.

The purpose of the study is to answer three key research questions: 1. What effect does supervised, progressive resistance training (PRT) have on the number and incidence of falls in older adults with impaired balance? 2. What effect does supervised, PRT have on balance in older adults with impaired balance? 3. What effect does supervised, PRT have on self-reported quality of life of older adults with impaired balance?