ANZCTR search results

There is limited published literature about the effectiveness of protocol initiated discharge in short-stay post-surgical units. The current study enrolled 182 participants who were randomly allocated to intervention or control groups.

The primary objectives of the study are to assess the safety, tolerability and pharmacokinetics of intact prodrug, PF329, as well as the pharmacokinetics of its pharmaceutically active form, hydromorphone, following increasing doses of a single oral administration of PF329 in healthy adult subjects

This pilot study looks at the effectiveness of acupuncture to reduce fatigue in women after treatment for breast cancer. You can join this study if you have recently been treated for breast cancer with chemotherapy, and you are suffering from fatigue associated with this treatment. Participants will be divided into three groups: an acupuncture treatment group, a placebo acupuncture group and a wait-list control group. Both the acupuncture and the placebo acupuncture groups will receive a type of acupuncture twice weekly over the first three weeks and then weekly for the final three weeks, with each treatment lasting 45 minutes. The placebo group will use a device which has a guide tube making it impossible for the subject to see whether the needle has penetrated the skin or not. Needle penetration does not occur. The sham needle will be placed away from acupuncture points. The wait list control group will receive no treatment for 6 weeks but will answer questionnaires during this time and be offered acupuncture treatment at the end of the 6 week study period. From 25% to 99% of people receiving cancer treatment suffer from fatigue. Preliminary reports suggest that acupuncture may help improve quality of life. The results of this study will be used in the design of a larger trial on the use of acupuncture to support cancer care.

People with newly diagnosed obstructive sleep apnoea for treatment with continuous positive airway pressure through a nasal mask (cPAP) are assigned to use a new custom fitted mask or the best-fit commercially available standard mask. There are 6 planned study visits over the 12 month treatment period. Participants are asked to complete study questionnaires at each study visit.

We conducted a randomised cross-over dietary intervention trial to compare the effects of 1g EPA+DHA per day from two different sources – fish and fish oil capsules. Subjects were randomised to begin on one arm of the intervention for 12 weeks, followed by a 12-week washout period and finally the alternate arm for another 12 weeks. Various cardiovascular risk markers were measured at each time point. Statistical analyses were performed to compare changes with each intervention, and the changes between the two treatment arms. 11 participants (10 males and 1 female) with a mean age of 50.9 years were recruited from St. Vincent’s Hospital, Melbourne from September 2008 to May 2009. Both treatments increased erythrocyte omega-3 index significantly, while the fish treatment also appeared to have beneficial effects on blood pressure.

This study looks at the effectiveness of a psychological therapy designed to support young people with cancer and their families to make a positive transition from cancer patient to survivor. Who is it for? You can join this study if you are a young cancer survivor aged 15-25 who has finished treatment for either a primary or secondary cancer in the past 12 months. Trial details: Participants will be divided into two groups. One group will take part in 'ReCaPTure LiFe', a cognitive-behavioural program designed to help people build skills to return to normality after cancer treatment. This will take place in six 90-minute group sessions, delivered weekly over the internet. Participants will complete a 1-week, 3-month and 12-month follow-up. The second group will take part in an open discussion forum with the same schedule. The study aims to monitor the distress, psychological adjustment and coping after cancer treatment.

This study aims to evaluate quality of life, physical, cognitive and language outcomes for a holistic new model of care for people living in the community with Parkinson's disease. The model incorporates physical, cognitive and speech activities into one program and compares outcomes between the enhanced multifactoral program with a traditional exercise program. Longer term outcomes will also be assessed at intervals up to six months with an aim to evaluate the optimum time for introduction of a maintenance program to people with Parkinson's disease.

The effectiveness of treatments to reduce heart disease risk can vary a great deal between individuals. This is partly due to an individual’s genetic makeup. Fatty acid metabolites called cytochrome P450 metabolites of arachidonic acid (CYP450-AAM) can act on blood vessels and the kidney to regulate blood pressure. One of these metabolites (20-HETE) is known to be affected by body weight. We will study volunteers with two different genetic make-ups that have different effects on the levels of 20-HETE, to see if they affect blood pressure and heart disease risk. We will assess whether having either genetic make-up causes a different blood pressure and plasma and urinary 20-HETE response when volunteers reduce their weight.

This study is testing the hypothesis that improvements in cardiovascular health with omega-3 fatty acid supplements are attributed to improvements in vascular function.

The principal objective of the trial is to test the hypothesis that Online Adaptive Radiotherapy for Muscle Invasive Bladder Cancer is feasible across multiple Radiation Oncology departments.