ANZCTR search results

This research study seeks to evaluate the effectiveness of a generic chronic disease self management program by implementing a randomised control trial. A pre-test and pilot study have previously been completed. The trial will be conducted in Sydney West Area Health Service. The research study will be undertaken collaboratively with the local area health service and Divisions of General Practice. Expression of Interests will be sought from a wide range of health care providers (GPs, clinicians working for the Area Health Service, Outpatient Department clinicians, community health and primary health care nurses, public and private allied health clinicians) to refer patients/clients based on an eligibility criteria to the study. The participating health care professionals will receive briefing on the referral process and be required to sign a consent form to participate. On referral, patients/clients will receive a study package containing information about the study, consent form and baseline survey. Return of the consent form and baseline survey by the patient/client will constitute enrollment in the study. At this point patient/clients will be allocated randomly to either participation in the intervention group (generic chronic disease self management program) or the control program (light physical activity program). Patients/clients who enrol in the study will be requested to complete a self administered questionnaire before and at 4 months post program attendance, to assess outcomes associated with attending the program. In addition, participants attending the generic chronic disease self managemet program will be requested to complete a process evaluation survey at the end of the first session and on completion of the program.

This is a controlled single-blind randomised study assessing the effect of prewarming on outcomes of patients with severe cerebral palsy undergoing major orthopaedic surgery. The study objectives are to assess the effect of prewarming participants prior to anaesthesia with regard to: i) Avoiding hypothermia. ii) Duration of recovery from anaesthesia. iii) Amount of surgical blood loss. iv) Rate of wound infections.

The purpose of this study is to determine efficacy of treatment with bortezomib (in combination with doxorubicin and dexamethasone) in previously untreated patients with Multiple Myeloma

This is a study to determine the maximum dose of CP-870,893 that can be safely administered in combination with standard chemotherapy (cisplatin and pemetrexed) as the treatment of patients with malignant pleural mesothelioma that can't be removed surgically. Who is it for? You can join this study if you have malignant pleural mesothelioma that cannot be removed surgically and are planned to receive treatment with standard chemotherapy (cisplatin and pemetrexed) . Trial details: Participants will receive standard treatment with cisplatin and pemetrexed chemotherapy which is given intravenously every 3 weeks, with the addition of CP-870,893 (CD40 activating antibody) on day 8 of each cycle. CP-870,893 activates the immune system which might help treat the cancer. Assessment for side effects by patient questionnaires and assessment by health professional, and collection of blood tests will occur weekly whilst on treatment and at 90-day follow-up visit. Tumour response will be measured with scans after the first cycle of treatment (PET scan), and after every 2 cycles of treatment (CT scan). The study aims to determine the maximum dose, side effects and effectiveness of CP-870,893 that can be safely administered in combination with standard chemotherapy as the first line treatment for malignant mesothelioma. It will also help to characterise the body's immune response to the treatment. After the maximum dose of CP-870,893 has been determined, 6 patients receiving the treatment at the maximum dose will have biopsies taken of the cancer before treatment starts and at the completion of treatment.

The primary aim of this trial is to compare the outcomes and adverse events of two different physiotherapy treatment approaches for people with multi-factorial persistent low back pain. A secondary aim is to determine the perspectives of participants on the functional restoration program utilised in the trial.

Removal of the tracheal tube can be performed while children are still deeply anesthetized or when they are awake. Each technique has its own advantages and disadvantages. In healthy children, it has been shown that there are no clinical differences between extubation in the awake state vs anesthetized state. In patients with a high risk of developing a postoperative respiratory complication such as those with asthma, it may be preferable to remove the tracheal tube while the patients are still anesthetized to avoid airway stimulation and consecutively bucking, coughing and bronchospasm. The results of a recent large prospective cohort study at our institution with over 9000 children allow to identify children with a high risk for developping postoperative respiratory complications. The aim of this present randomized controlled trial is to assess whether children at a high risk for respiratory problems benefit from anethetized extubation as compared to awake extubation following adeno-/tonsillectomy. We hypothesize that children with a high risk for respiratory problems defined by the presence of either airway susceptibility, eczema or a positive family history will demonstrate less respiratory problems when extubated anaesthetised compared with high risk children who are extubated awake.

This clinical trial is designed to test whether the three commonly used oral steroid treatment regimes for croup, are equally effective. Children will receive one of the three treatments, decided by a random process, and their improvement and outcomes monitored by investigators who are blinded to the treatment received.

This study will examine whether the impairing effects of sleep loss, alcohol and hypnotic drugs can be detected using a simulated driving task and drowsiness monitoring technology in the laboratory setting. The hypothesis of this study is that performance deterioration, as a result of sleep restriction and acute benzodiazepine administration, can be detected by increases in slow eyelid closure, a reduction in amplitude of eyelid opening and a reduction in saccadic eye movements, as measured by Optalert.

Infertility can lead to emotional distress which may place some people at risk of developing a mental health problem. The use of complimentary and alternative therapies are growing in popularity and there is some evidence that acupuncture may increase pregnancy rates in women undergoing In Vitro Fertilisation (IVF). Research findings suggest acupuncture given to women when trying to get pregnant may also lead to an improvement in their emotional well being, and that women may cope better with their IVF treatment. We propose to undertake a pilot randomised controlled trial of acupuncture to explore these effects.

The primary aim of this proposal is to compare LAGB surgery with optimal medical therapy over the period of the 2-year trial. The hypothesis is LAGB provides better results.