ANZCTR search results

To evaluate use of cognitive behavioural therapy to treat anxiety and depression in clients with Asperger's Disorder

The aim of this study is to determine if injecting corticosteroid into the knee during total knee replacement results in improved pain and function (in the short to medium term).

A melanoma-specific QoL questionnaire is being developed in a cross-cultural setting using a four phase process developed by the European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Group. This study has shown that melanoma patients have important QoL issues that have been incorporated into a new cross-culturally validated instrument.

The primary aim of this trial is to compare the outcomes and adverse events of two different physiotherapy treatment approaches for people with reducible discogenic low back pain (with or without associated leg symptoms). A secondary aim is to determine the perspectives of participants on the specific physiotherapy treatment and advice utilised in the trial.

Adenosine has never been studied in coronary angioplasty in the setting of non ST segment elevation acute coronary syndrome. With promising observations of the benefits of adenosine in both elective and primary angioplasty settings, we hypothesise that intracoronary adenosine may prevent myocyte death (periprocedural myonecrosis) in this groups of patients undergoing coronary angioplasty. We hypothesise that pretreatment with a intracoronary bolus dose of adenosine before coronary angioplasty decreases the amount of periprocedural myonecrosis in patients with non ST segment elevation acute coronary syndrome

At present few methods of determining dietary intake in this group have been validated. The aim of the study is to evaluate the validity of two dietary assessment instruments (Cancer Council’s Food Frequency Questionnaire (FFQ) and duplicate 24h recall) against a reference technique (3-day weighted record) in a sample of community-dwelling older adults. This will potentially provide Dietitians (particularly researchers) with a simple, valid tool to assess dietary intake in this population

This study looks at the safety and effectiveness of using T cell therapy targeting Human Cytomegalovirus (HCMV) in treating brain cancer (glioblastoma multiforme or GBM). Who is it for? You can join this study if you have brain cancer (glioblastoma multiforme) that has progressed or recurred since it was first diagnosed. Trial details Participants will receive treatment with killer T cells (a type of white blood cell) which have been grown in the laboratory from the participant’s own white blood cells. Treatment is 4 fortnightly infusions, and patients are monitored for 12 months afterwards to see if treatment is safe and to measure any reduction in tumour and amount of virus in the blood. Recent studies suggest that most gliomas carry a common virus, called human cytomegalovirus (HCMV), which is normally controlled by killer T cells. The study aims to see if killer T cells grown in the laboratory and trained to recognise and kill the virus can also kill HCMV infected gliomas. The standard first-line treatment is usually surgery, radiotherapy and a chemotherapy drug called temozolomide. If the cancer then grows back, there are no known effective treatments.

Fat emulsions are an essential part of parenteral nutrition (PN) combining a high energy load with an essential fatty acid (EFA) intake.The primary purpose of this study is to test the safety and efficacy of new fish oil based intravenous fat emulsion (SMOFlipid) as compared to traditional olive oil based intravenous fat emulsion (Clinoleic). This study will specifically look at plasma and red cell fatty acid levels particularly Docosahexaenoic acid (DHA) which plays an important role in development and vision of newborn babies and also oxidative strss levels (F2-isoprostanes) before and after the intervention in a randomised controlled trial.

While basal-bolus insulin management is preferred over sliding scale for glycaemic control of hospitalised diabetics requiring intensified glycaemic control, there are no recommended basal-bolus approaches, and little data comparing the 2 approaches. The development of our basal-bolus approach requires testing to ensure its clinical efficacy, and that it is actually a better practice than sliding scale insulin. The main comparator will be the mean daily glucose readings taken from the routine four times daily capillary blood glucose measurements.

Timely and accurate discharge summaries play a critical role in the continuity of patient care between hospitals and primary care physicians or general practitioners in the community. The objective of this study was to examine the effectiveness of delivering of computer-generated discharge summaries to general practice by email, fax, post and patient hand-delivery.