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Screening for Colorectal Cancer in Recipients of Kidney Transplants
Expand descriptionThe risk of cancer, including colorectal cancer is increased in recipients of kidney transplants. This study is designed to evaluate the standard population screening tools for colorectal cancer, ie faecal occult blood testing and colonoscopy, in this high risk population. All recruited patients will undergo both of these screening tests, and from this we will investigate the rates of colorectal cancer and pre-cancerous growths in this population, and the usefulness of the two screening tests for this group of patients.
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Investigation of the role of tumour-associated macrophages in the development and progression of lung cancer
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Obesity prevention impact of removing caffeine from soft drinks
Expand descriptionThis research program will test the hypotheses that removing caffeine from soft drinks will significantly decrease liking of and energy intake from these products and that this reduction in energy intake is sufficient to reduce average body weight in the Australian population. This project has two key aims: 1. To determine if the removal of caffeine from soft drinks results in a decreased consumption of these beverages. 2. To use these results to model the effect of caffeine removal from soft drinks on total energy intake and body weight of the Australian Population.
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An intervention study for bronchiolitis in Darwin and Townsville - Comparing severity of disease and readmission of infants given azithromycin or placebo.
Expand descriptionIn a previous study on bronchiolitis in Aboriginal children we found that 67% were from remote communties and required retrievals. A recent study has also shown that almost 2.5% of Aboriginal children in Australia's Northern Territory will be hospitalised for bronchiolitis more than once before reaching the age of 18 months. Multiple hospitalised respiratory infections and the severity of these infections are risk factors for developing chronic lung diseases including bronchiectisis and asthma. It is planned that this study will provide an estimation of the effect of azithromycin on the severity of bronchiolitis in Aboriginal and non Aboriginal infants. Assessing redmission for respiratory illness within 6 months may provide some indication of the medium term benefit of a single dose of azithromycin, given to infants in the acute phase of viral bronchiolitis, in reducing the risk of further respiratory illness requiring hospitalisation.
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Ear-acupressure for hay fever
Expand descriptionThis study proposes to evaluate the efficacy and safety of ear-acupressure in the treatment of adult patients with allergic rhinitis by conducting a multi-centre, randomised, sham-controlled clinical trial. A pilot study will be conducted in Australia prior to the main trial.
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A randomised, double-blind, placebo-controlled, dose-ranging study to evaluate the safety, efficacy and pharmacokinetics of 3 doses of ART621 following multiple dose administration in subjects with stable plaque psoriasis
Expand descriptionThe primary objective is to evaluate the safety and tolerability of subcutaneous injections of ART621 given every 2 weeks for 6 doses as assessed by adverse events and clinical laboratory data. Assessments of efficacy will include the Psoriasis Area and Severity Index (PASI), Physician Global Assessment (PGA), photographs and the Dermatology Life Quality Index (DLQI). Each subject will be on-study for 18-20 weeks, consisting of a 2-4 week screening period, followed by a 12 week treatment period and then a 4 week follow up. Each subject will receive their designated dose of ART621 on 6 occasions over the 12 week treatment period and will be monitored closely throughout.
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Exercise for people with dust-related lung disease.
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Using real time ultrasound to assit with urine collection
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Closing the skin and subcutaneous layers at Caesarean section to reduce wound complications
Expand descriptionCaesarean section is a common operation and for different parts of the operation techniques vary widely between surgeons. Information is lacking about the best techniques and how different techniques may affect the mother's health. We propose to evaluate two methods of stitching up or closing the skin and whether to close or not to close the fatty layer beneath the skin. We want to know if these different methods cause differences in wound problems after birth and also whether there is a difference in pain and the mothers general physical and emotional health. We aim to examine these methods in approximately 700 women over a 2 year period and will follow them until 6 weeks after the birth.
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Acute alerting effects of daytime exposure to specific wavelengths of light
Expand descriptionThis study examines the effects of different colours of light on sleepiness and performance on various tasks. It is predicted that exposure to blue light will reduce sleepiness and improve performance more effectively than other colours of light.