ANZCTR search results

This project will determine whether standard care or cardiology care improves survival for patients undergoing emergency orthopaedic-geriatric surgery with a troponin rise. A pilot study conducted at The Northern Hospital in 2006 revealed that at one year mortality rate was 21% in this population and those with a troponin rise were more at risk of dying. Therefore, this RCT is proposed to see if cardiology care is any better than standard care to improve survival.

Numerous studies have demonstrated comorbidity between migraine and tension-type headache on the one hand, and depression on the other. It is not clear whether this reflects a causal relationship between headaches and depression or common predispositional factors. Presence of depression is a negative prognostic indicator for behavioral treatment of headaches. Despite the recognised comorbidity, there is limited research literature evaluating interventions designed for comorbid headaches and depression. Sixty six participants (49 female, 17 male) suffering from migraine and/or tension-type headache and major depressive disorder were randomly allocated to a Cognitive Behavior Therapy program, or a control group (Routine Primary Care). The treatment program involved 12 weekly 50-minute sessions administered by clinical psychologists. Participants in the treatment and control groups significantly differed from baseline to post-treatment on measures of headaches, depression, anxiety, and quality of life. Improvements achieved with treatment were maintained at four month follow-up. Changes in headaches and depression were not significantly correlated suggesting that the relationship between them may not be causal. Comorbid anxiety disorders were not a predictor of response to treatment, and the only significant predictor was gender (men improved more than women). The new integrated treatment program appears promising and worthy of further investigation.

We aim to measure the migration pattern of the tibial base plats using RSA. We would also like to compare RSA and clinical questionnaire data (oxford knee score and EQ5D score) regarding Genesis II MIS tibial base plate to a previous study involving standard Genesis II tibial base plates

Study Rationale: The current choice of treatment for intertrochanteric fracture is the Dynamic Hip Screw. Technical and mechanical failure of this device currently occurs in 6-18% of all cases. Better understanding, more validated data and the need for better treatment regarding intertrochanteric fracture is necessary. "Prospective studies comparing the trochanteric nail, with and without distal interlocking to the sliding/dynamic hip screw are warranted". Study Aim: The purpose of this prospective randomised study is to compare the intramedullary gamma nail to the dynamic hip screw in regards to functional outcome. Specific Aims: The aim of this study is to compare the results of the surgical intervention with parameters such as operative time, blood loss, operative complications and cost for each device. In the post operative period the functional results of patients will be compared with initial mobilisation and discharge through to long term function and return to activities of daily living. The degree of fracture collapse will be recorded and compared to function. Long term fracture union will also be assessed.

The project aims to demonstrate that transversus abdominis plane block is an effective adjunct to multi-modal analgesia in the setting of major gynaecological surgery via midline laparotomy. The project aims to demonstrate that the technique improves overall pain relief, reduces morphine consumption (and opioid side effects) and improves patient satisfaction.

This is a study of an experimental anti-cancer drug called CYT997, which targets the blood supply of the tumour. In this study, CYT997 is given as a 24 hour intravenous (IV) infusion on day 2 of a 21 day treatment cycle over 3 cycles. In this study, CYT997 is given in combination with another commonly used standard chemotherapy drug called Carboplatin. You may be eligible to join this study if you have Relapsed Glioblastoma Multiforme and a life expectancy of more than two months. Most advanced cancers will eventually stop responding to cancer treatments. In this situation, for people who may be eligible for this drug trial, there may not be any alternative standard treatments. Participants will receive supportive care and symptomatic treatments during the trial, in addition to receiving CYT997 and Carboplatin. The major focus of this trial is to test the safety, tolerability and effectiveness of CYT997 when given in combination with Carboplatin in patients with Relapsed Glioblastoma Multiforme. This involves finding out the highest dose of CYT997 that can be given without causing severe side effects. The trial also aims to assess the effects (good and bad) that CYT997 may have on you and your cancer.

Patients admitted to RGH for a lower-limb amputation will be invited to participate in a study investigating the effect of a diet that is enriched with arginine on the time taken for the amputation wound to heal, and the time taken to have a prosthetic limb fitted. Participants will be allocated at random to receive either a standard hospital diet with 2 Arginine-enriched supplements or a standard hospital diet with 2 standard nutritional supplements, that are equal in energy, protein, vitamins and minerals. In addition to the time taken for the wound to heal, participants will also have their nutritional health measured via body weight, dietary intake and arm muscle stores. Quality of life will also be measured.

People with severe curvature of the spine (kyphoscoliosis) have a reduced exercise capacity and are often limited by their respiratory system. The aim of this study was to determine the effect of low level and high level breathing support (provided via a mask) during treadmill walking in people with severe curvature of the spine (kyphoscoliosis) compared to sham breathing support and walking unassisted. We hypothesised that only high level breathing support would increase exercise endurance time in people with severe kyphoscoliosis.